Autoimmunity Branch
Led by Dr. Richard Siegel, the branch investigates autoimmunity, a feature of rheumatic diseases, such as lupus, rheumatoid arthritis, and dermatomyositis.Biodata Mining and Discovery Section
Led by Dr. Hong-Wei Sun, the Biodata Mining and Discovery Section facilitates biomedical research to support NIAMS IRP scientists and their discoveries.
Clinical and Investigative Orthopedics Surgery Unit
Led by Dr. Timothy Bhattacharyya, the unit investigates orthopedic conditions, including femur fractures and hip infections, and related treatments.
Clinical Research @ NIAMS
Based on Translational Research methods, NIAMS clinical trials give researchers a biological understanding of a disease that can inform their studies.
Clinical Trials and Outcomes Branch
Led by Dr. Michael Ward, the branch investigates health outcomes in patients with SLE, rheumatoid arthritis, and ankylosing spondylitis, and explores tools for measuring them.
Cutaneous Development and Carcinogenesis Section
The Cutaneous Development and Carcinogenesis Section studies the signaling pathways such as Hedgehog signaling that regulate the development and maintenance of normal skin, and the changes in these signals that occur during the formation of skin cancer. Our investigations include studying the specification and maintenance of cell lineages in the skin, as well as studying the regulation of stem cells in the skin, and using mouse genetics to model carcinogenesis in the skin.
Cutaneous Leukocyte Biology Section
Led by Keisuke (Chris) Nagao, the section investigates cellular and molecular mechanisms that regulate immunological and structural homeostasis in the skin.
Cutaneous Microbiome and Inflammation Section
The Cutaneous Microbiome and Inflammation section is focused on studying the skin microbiome in healthy individuals with the goal of expanding our understanding of host-microbe interactions. Previous work has investigated the diversity and distrubution of bacterial and fungal skin communities in healthy adults.
Dermatology Branch
Led by Dr. Edward Cowen, M.D., the branch conducts both clinical and basic research studying the etiology, diagnosis, and treatment of inflammatory and malignant diseases involving the skin and the host's response to these diseases.
Dermatology Consultation Service
Through the Dermatology Consultation Service at the NIH Clinical Center, patients with a variety of rare diseases with cutaneous manifestations are evaluated. In addition, patients who experience adverse reactions to experimental therapeutic agents or manifest unrelated skin conditions while at the NIH are evaluated and treated. Dermatology Branch clinical fellows, fellows from other NIH Institutes, and visiting dermatology residents from around the country receive training on the Dermatology consult service.
Flow Cytometry Section
The Flow Cytometry Section provides state-of-the-art multi-parameter cellular analysis and cell sorting for NIAMS researchers and investigators.
Genomics and Immunity Section
Led by Dr. Rafael Casellas, the section combines molecular biology and gene targeting to study early development and activation of B lymphocytes.
Immunodeficiency and Inflammation Unit
Led by Dr. Eric Hanson, the unit investigates immune deficiency and related diseases by evaluating individuals with genetic syndromes.
Immunoregulation Section
Led by Dr. Richard Siegel, the section investigates how changes in regulatory signaling pathways in immune cells impact autoimmune and inflammatory diseases.Laboratory Animal Care and Use Section
LACU provides animal care services to support NIAMS Intramural Research Program Branches and Laboratories that use animals in their research studies.
Laboratory of Molecular Immunogenetics
Led by Dr. Rafael Casellas, the lab investigates immune cell processes, and how they impact autoimmune and other inflammatory diseases.
Laboratory of Muscle Stem Cells and Gene Regulation
Led by Dr. Vittorio Sartorelli, the lab studies mechanisms that regulate specification, differentiation, and regeneration of skeletal muscle cells.
Laboratory of Oral Connective Tissue Biology
Dr. Martha Somerman leads studies of the molecular biology of dental-oral-craniofacial development, with a focus on the periodontal complex.
Laboratory of Skin Biology
Led by Dr. Maria Morasso, the lab studies processes that lead to epidermal differentiation and barrier formation, and their role in skin disorders.
Laboratory of Structural Biology Research
Led by Dr. Alasdair Steven, this lab studies viruses, cytoskeletal filaments, and energy-dependent proteases to explain macromolecular complexes.
Light Imaging Section
The NIAMS Light Imaging Section provides scientists light imaging tools, and training on analysis of images with techniques of light microscopy.
Lupus Clinical Trials Unit
Led by Dr. Sarfaraz Hasni, the unit studies the natural history and pathogenesis of lupus and involved in designing and conducting early phase clinical trials.
Molecular Immunology and Inflammation Branch
Led by Dr. John O’Shea, the branch investigates how T cells play a role in both immune defense and development of immune-mediated diseases.
Molecular Therapeutics Unit
Led by Dr. Keith Sikora, the unit studies juvenile-onset spondyloarthritis, which often develops into AS, a form of inflammatory arthritis.
Muscle Disease Unit
Led by Dr. Andrew Mammen, the unit researches human muscle diseases, as well the basic biology of skeletal muscle regeneration.Muscle Energetics Laboratory
The focus of Dr. Glancy’s muscle energetics research program is to determine how mitochondria are optimized within muscle cells to help maintain energy homeostasis during the large change in energy demand caused by muscle contraction.
Office of Science and Technology
The Office of Science and Technology (OST) is responsible for NIAMS Labs core facilities. It provides and develops new technologies, advises the Scientific Director, Lab and Branch Chiefs, and other key officials on science and technology. OST initiates collaborative, cooperative and service activities that facilitate the conduct of science and coordinates the core technological facilities of the Intramural Research Program.
Pediatric Translational Research Branch
Led by Dr. Robert Colbert, the branch studies Spondyloarthritis, particularly early-onset Ankylosing Spondylitis and spinal development in children.
Protein Expression Laboratory
Led by Paul Wingfield, the lab supports NIH research projects by analyzing and providing HIV proteins to their researchers and scientists.
RNA Molecular Biology Group
Led by Dr. Markus Hafner, the group studies the makeup of ribonucleoproteins (RNPs) involved in cellular RNA transport and control of RNA stability.
Systemic Autoimmunity Branch
Led by Dr. Mariana Kaplan, the branch studies autoimmune diseases, like lupus and rheumatoid arthritis, seeking treatments and improved outcomes.
Translational Genetics and Genomics Unit
Led by Dr. Michael Ombrello, the unit uses genomic approaches to understand the underlying factors of autoinflammatory and rheumatic diseases.
Translational Immunology Section
TIS provides NIAMS researchers cutting-edge immune monitoring technology as they strive to develop accurate and reproducible immune monitoring assays.