Summary

Dr. Dell’Orso received her Ph.D. from the University of Rome in Italy and conducted her post-doc research at the NIAMS where she focused on the role of transcription factors, chromatin regulators, ncRNAs and epigenetic marks during skeletal muscle specification and development. In 2016 she joined the NIAMS Genomic Technology Section where she provides consultation on experimental design and library preparation and works with NIAMS scientists to implement genomics and sequencing technologies.

Research Statement

The Genomic Technology Section  at NIAMS is a multi-disciplinary genomics facility that supports NIAMS investigators with the latest on DNA sequencing and library preparation technologies. The Section works closely with NIAMS scientists to explore the use and implementation of leading edge genomics technologies, molecular biology protocols and analytical procedures as well as consultation and training for researchers with specific needs or challenging problems.

Scientific Publications

A Muscle-Specific Enhancer RNA Mediates Cohesin Recruitment and Regulates Transcription In trans.

Tsai PF, Dell'Orso S, Rodriguez J, Vivanco KO, Ko KD, Jiang K, Juan AH, Sarshad AA, Vian L, Tran M, Wangsa D, Wang AH, Perovanovic J, Anastasakis D, Ralston E, Ried T, Sun HW, Hafner M, Larson DR, Sartorelli V
Molecular cell.
2018 Jul 5;
71(1).
doi: 10.1016/j.molcel.2018.06.008
PMID: 29979962

Neutrophil subsets and their gene signature associate with vascular inflammation and coronary atherosclerosis in lupus.

Carlucci PM, Purmalek MM, Dey AK, Temesgen-Oyelakin Y, Sakhardande S, Joshi AA, Lerman JB, Fike A, Davis M, Chung JH, Playford MP, Naqi M, Mistry P, Gutierrez-Cruz G, Dell'Orso S, Naz F, Salahuddin T, Natarajan B, Manna Z, Tsai WL, Gupta S, Grayson P, Teague H, Chen MY, Sun HW, Hasni S, Mehta NN, Kaplan MJ
JCI insight.
2018 Apr 19;
3(8).
pii: 99276. doi: 10.1172/jci.insight.99276
PMID: 29669944

The Elongation Factor Spt6 Maintains ESC Pluripotency by Controlling Super-Enhancers and Counteracting Polycomb Proteins.

Wang AH, Juan AH, Ko KD, Tsai PF, Zare H, Dell'Orso S, Sartorelli V
Molecular cell.
2017 Oct 19;
68(2).
doi: 10.1016/j.molcel.2017.09.016
PMID: 29033324

Laminopathies disrupt epigenomic developmental programs and cell fate.

Perovanovic J, Dell'Orso S, Gnochi VF, Jaiswal JK, Sartorelli V, Vigouroux C, Mamchaoui K, Mouly V, Bonne G, Hoffman EP
Science translational medicine.
2016 Apr 20;
8(335).
doi: 10.1126/scitranslmed.aad4991
PMID: 27099177

The Histone Variant MacroH2A1.2 Is Necessary for the Activation of Muscle Enhancers and Recruitment of the Transcription Factor Pbx1.

Dell'Orso S, Wang AH, Shih HY, Saso K, Berghella L, Gutierrez-Cruz G, Ladurner AG, O'Shea JJ, Sartorelli V, Zare H
Cell reports.
2016 Feb 9;
14(5).
doi: 10.1016/j.celrep.2015.12.103
PMID: 26832413

The NAD(+)-dependent SIRT1 deacetylase translates a metabolic switch into regulatory epigenetics in skeletal muscle stem cells.

Ryall JG, Dell'Orso S, Derfoul A, Juan A, Zare H, Feng X, Clermont D, Koulnis M, Gutierrez-Cruz G, Fulco M, Sartorelli V
Cell stem cell.
2015 Feb 5;
16(2).
doi: 10.1016/j.stem.2014.12.004
PMID: 25600643

Education

University of “La Sapienza”, Rome, Italy

Laboratory of Muscle Stem Cells and Gene Regulation, NIAMS, NIH

Experience

Chief
Genomic Technology Section, OST, NIAMS, NIH

Senior Staff Scientist
Genomic Technology Section, OST, NIAMS, NIH

Research Fellow
Genomic Technology Section, OST, NIAMS, NIH

Post-doc
Laboratory of Muscle Stem Cells and Gene Regulation, NIAMS, NIH

Last Updated: June 2020