Summary

Dr. Grayson is board-certified in Internal Medicine and Rheumatology. He completed his undergraduate degree from Brown University in 1999, his medical degree from the Medical University of South Carolina in 2004, and a Masters in Science from Boston University in 2008. He served as a Chief Resident in Internal Medicine at Boston Medical Center and completed an additional two-year vasculitis fellowship within the Vasculitis Clinical Research Consortium. 

Currently, an Earl Stadtman Investigator at the NIAMS, Dr. Grayson’s research focuses on clinical and translational research across many forms of systemic vasculitis. Specifically, his work has focused on biomarker discovery/development, the use of advanced molecular imaging, molecular classification of disease, clinical trials, and genetics/genomics of vasculitis. His group has clinically defined the use of advanced molecular imaging as a surrogate marker of vascular inflammation in large-vessel vasculitis.  His group has conducted some of the only translational work related to relapsing polychondritis, including the identification of somatic mutations in UBA1 as a driver of disease in a subset of these patients.  Translational work from the group has also defined novel pathways of neutrophil-mediated inflammation in monogenic vasculitis and drug-induced vasculitis and has identified novel biomarkers of disease activity in many forms of vasculitis that suggest novel therapeutic targets.

Dr. Grayson has a strong commitment to mentoring young investigators in rare disease research. He serves as the Associate Program Director for the NIAMS Rheumatology Fellowship Program and he is the recipient of numerous teaching awards. He is actively involved in leadership roles within the American College of Rheumatology and was a recipient of the American College of Rheumatology’s Distinguished Fellow Award in 2011. He has served on the editorial board for Arthritis & Rheumatology and the Journal of Rheumatology. He currently serves on the Board of Directors for the Vasculitis Foundation and is a Steering Committee member on the Vasculitis Clinical Research Consortium.

Scientific Publications

Somatic Mutations in UBA1 and Severe Adult-Onset Autoinflammatory Disease.

Beck DB, Ferrada MA, Sikora KA, Ombrello AK, Collins JC, Pei W, Balanda N, Ross DL, Ospina Cardona D, Wu Z, Patel B, Manthiram K, Groarke EM, Gutierrez-Rodrigues F, Hoffmann P, Rosenzweig S, Nakabo S, Dillon LW, Hourigan CS, Tsai WL, Gupta S, Carmona-Rivera C, Asmar AJ, Xu L, Oda H, Goodspeed W, Barron KS, Nehrebecky M, Jones A, Laird RS, Deuitch N, Rowczenio D, Rominger E, Wells KV, Lee CR, Wang W, Trick M, Mullikin J, Wigerblad G, Brooks S, Dell'Orso S, Deng Z, Chae JJ, Dulau-Florea A, Malicdan MCV, Novacic D, Colbert RA, Kaplan MJ, Gadina M, Savic S, Lachmann HJ, Abu-Asab M, Solomon BD, Retterer K, Gahl WA, Burgess SM, Aksentijevich I, Young NS, Calvo KR, Werner A, Kastner DL, Grayson PC
N Engl J Med.
2020 Dec 31;
383(27).
doi: 10.1056/NEJMoa2026834
PMID: 33108101

Defining Clinical Subgroups in Relapsing Polychondritis: A Prospective Observational Cohort Study.

Ferrada M, Rimland CA, Quinn K, Sikora K, Kim J, Allen C, Sirajuddin A, Goodspeed W, Chen M, Grayson PC
Arthritis Rheumatol.
2020 Aug;
72(8).
doi: 10.1002/art.41270
PMID: 32249511

Deficiency of adenosine deaminase 2 triggers adenosine-mediated NETosis and TNF production in patients with DADA2.

Carmona-Rivera C, Khaznadar SS, Shwin KW, Irizarry-Caro JA, O'Neil LJ, Liu Y, Jacobson KA, Ombrello AK, Stone DL, Tsai WL, Kastner DL, Aksentijevich I, Kaplan MJ, Grayson PC
Blood.
2019 Jul 25;
134(4).
doi: 10.1182/blood.2018892752
PMID: 31015188

18 F-Fluorodeoxyglucose-Positron Emission Tomography As an Imaging Biomarker in a Prospective, Longitudinal Cohort of Patients With Large Vessel Vasculitis.

Grayson PC, Alehashemi S, Bagheri AA, Civelek AC, Cupps TR, Kaplan MJ, Malayeri AA, Merkel PA, Novakovich E, Bluemke DA, Ahlman MA
Arthritis Rheumatol.
2018 Mar;
70(3).
doi: 10.1002/art.40379
PMID: 29145713

A role for muscarinic receptors in neutrophil extracellular trap formation and levamisole-induced autoimmunity.

Carmona-Rivera C, Purmalek MM, Moore E, Waldman M, Walter PJ, Garraffo HM, Phillips KA, Preston KL, Graf J, Kaplan MJ, Grayson PC
JCI Insight.
2017 Feb 9;
2(3).
doi: 10.1172/jci.insight.89780
PMID: 28194438

Neutrophil-Related Gene Expression and Low-Density Granulocytes Associated With Disease Activity and Response to Treatment in Antineutrophil Cytoplasmic Antibody-Associated Vasculitis.

Grayson PC, Carmona-Rivera C, Xu L, Lim N, Gao Z, Asare AL, Specks U, Stone JH, Seo P, Spiera RF, Langford CA, Hoffman GS, Kallenberg CG, St Clair EW, Tchao NK, Ytterberg SR, Phippard DJ, Merkel PA, Kaplan MJ, Monach PA, Rituximab in ANCA-Associated Vasculitis-Immune Tolerance Network Research Group.
Arthritis Rheumatol.
2015 Jul;
67(7).
doi: 10.1002/art.39153
PMID: 25891759
Last Updated: November 2020