The mission of the Genomic Technology Section is to help NIAMS investigators solve highly diverse biological and biomedical research questions by providing a diverse portfolio of sequencing services as well as consultation and training for researchers with specific needs or challenging problems. The core is a state-of-the-art laboratory facility equipped with the latest DNA sequencing and library preparation technologies. A wide array of sample preparation methods enable the use of diverse applications, including: Whole-genome sequencing, RNA-Seq, small RNA discovery, methylation profiling, genome-wide protein-DNA interaction analysis (ChIP-Seq) and ATAC-Seq, exome sequencing, amplicon sequencing, Single Cells RNA-seq, Single Cells ATAC-Seq and Single Cell western.

Scientific Publications



Dysregulated neutrophil responses and neutrophil extracellular trap formation and degradation in PAPA syndrome.

Mistry P, Carmona-Rivera C, Ombrello AK, Hoffmann P, Seto NL, Jones A, Stone DL, Naz F, Carlucci P, Dell'Orso S, Gutierrez-Cruz G, Sun HW, Kastner DL, Aksentijevich I, Kaplan MJ
Annals of the rheumatic diseases.
2018 Dec;
doi: 10.1136/annrheumdis-2018-213746
PMID: 30131320

A Muscle-Specific Enhancer RNA Mediates Cohesin Recruitment and Regulates Transcription In trans.

Tsai PF, Dell'Orso S, Rodriguez J, Vivanco KO, Ko KD, Jiang K, Juan AH, Sarshad AA, Vian L, Tran M, Wangsa D, Wang AH, Perovanovic J, Anastasakis D, Ralston E, Ried T, Sun HW, Hafner M, Larson DR, Sartorelli V
Molecular cell.
2018 Jul 5;
doi: 10.1016/j.molcel.2018.06.008
PMID: 29979962

Identification of Skeletal Muscle Satellite Cells by Immunofluorescence with Pax7 and Laminin Antibodies.

Feng X, Naz F, Juan AH, Dell'Orso S, Sartorelli V
Journal of visualized experiments : JoVE.
2018 Apr 19;
doi: 10.3791/57212
PMID: 29733324

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Last Updated: May 2020