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Crop of Microscope

The NIAMS Intramural Research Program (IRP) studies a vast portfolio of common and rare diseases under the NIAMS mission. These recent scientific advances bring attention to the rare diseases, the rise of novel findings from cutting-edge investigative biomedical research, and their impact on treatment.

TRANSLATIONAL

Loss of an Enzyme in the Endoplasmic Reticulum—a Cell’s Transportation System—Might Play a Protective Role in Spondyloarthritis

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NIAMS IRP
Spondyloarthritis is a family of inflammatory diseases that affects the spine, pelvic joints, shoulders, and knees. This study demonstrated that altering the expression of ERAP1 protein may protect against arthritis.
Cell Biology Clinical Research Genetics and Genomics Immunology Molecular Biology and Biochemistry
CLINICAL

Understanding the Relationship Between Vascular Inflammation Detected on a PET Scan with Future Risk to Develop Damage Within the Large Arteries

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NIAMS IRP
This study provides some of the first and only available data about the direct relationship between FDG-PET activity and angiographic change in large-vessel vasculitis.
Autoimmunity Clinical Research Computational Biology Genetics and Genomics Immunology
BASIC

Isolation and Culture of Muscle Stem Cells and Progenitor Cells

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NIAMS IRP
The protocol describes in detail the mechanical and enzymatic dissociation of mononucleated cells from whole limb muscles and injured tibialis anterior (TA) muscles to isolate FAPs and MuSCs. Additionally, it describes an optimized method for culturing quiescent and activated FAPs and MuSCs.
Cell Biology Developmental Biology Muscle Biology Stem Cell Biology
Last Updated: September 2023