The Microbiomes of People with Recombination-Activating Gene (RAG) Deficiency Have Distinct Features, Including Antimicrobial Resistance Signatures

The study characterizes the colonization of eukaryotic RNA viruses in RAG-deficient patient population and also demonstrates the importance of these patients as potential reservoirs of viral persistence and evolution.
Clinical Research Computational Biology Genetics and Genomics Microbiology and Infectious Diseases Skin Biology

Loss of an Enzyme in the Endoplasmic Reticulum—a Cell’s Transportation System—Might Play a Protective Role in Spondyloarthritis

Spondyloarthritis is a family of inflammatory diseases that affects the spine, pelvic joints, shoulders, and knees. This study demonstrated that altering the expression of ERAP1 protein may protect against arthritis.
Cell Biology Clinical Research Genetics and Genomics Immunology Molecular Biology and Biochemistry

Understanding the Relationship Between Vascular Inflammation Detected on a PET Scan with Future Risk to Develop Damage Within the Large Arteries

This study provides some of the first and only available data about the direct relationship between FDG-PET activity and angiographic change in large-vessel vasculitis.
Autoimmunity Clinical Research Computational Biology Genetics and Genomics Immunology

Isolation and Culture of Muscle Stem Cells and Progenitor Cells

The protocol describes in detail the mechanical and enzymatic dissociation of mononucleated cells from whole limb muscles and injured tibialis anterior (TA) muscles to isolate FAPs and MuSCs. Additionally, it describes an optimized method for culturing quiescent and activated FAPs and MuSCs.
Cell Biology Developmental Biology Muscle Biology Stem Cell Biology

Sex differences in neutrophil biology affect response to type I interferons and cellular metabolism

There are striking differences between men and women in their ability to respond to certain infections, predisposition to and prognosis in certain cancers, and risk for developing an autoimmune disease. However, the underlying mechanisms that drive the differences between the male and female immune system remain insufficiently characterized, especially for innate immune system cells like neutrophils.
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