The Lymphocyte Signaling Unit studies molecular processes that control immune cell development and function.

The goal of our research is to understand new aspects of lymphocyte biology. We use animal models, high-throughput sequencing, flow cytometry, and microscopy to uncover novel cellular and molecular characteristics that will give us more insight into what is critical for an immune cell to develop and respond to cancer and infection. Currently, our work focuses on how glycosphingolipid metabolism regulates how immune cells respond to signals from their environment that regulate homeostasis and activation.

Core Research Facilities

Labs at the NIAMS are supported by the following state-of-the-art facilities and services:


Group photo showing five members of the lab, outside in front of trees

Image & Media Gallery

Scientific Publications

Selected Recent Publications

Evolving Views of Long Noncoding RNAs and Epigenomic Control of Lymphocyte State and Memory.

Morrison TA, Hudson WH, Chisolm DA, Kanno Y, Shih HY, Ahmed R, Henao-Mejia J, Hafner M, O'Shea JJ
Cold Spring Harb Perspect Biol.
2022 Jan 4;
doi: 10.1101/cshperspect.a037952
PMID: 34001528