NIAMS faculty lead the way in innovative research into the causes, treatment, and prevention of arthritis and musculoskeletal and skin diseases. They are listed alphabetically below, followed by the leads of our core facilities.
Dr. Bhattacharyya's research involves studying and analyzing orthopaedic outcomes using a variety of clinical data sources. His team is interested in hip fractures, hip infections, joint replacement, atypical femur fractures, and nonunions.
Dr. Brownell is a board-certified dermatologist and a fellow of the American Academy of Dermatology. He directs a research program that includes basic, translational, and clinical investigations of skin homeostasis and skin cancer.
Dr. Colbert's research focuses on understanding the pathogenesis of chronic inflammation and its impact on the structural remodeling of bone in spondyloarthritic diseases, such as ankylosing spondylitis.
Dr. Cowen leads the NIH Dermatology Consultation Service, conducts independent and collaborative research, and oversees the continuing medication education-accredited Dermatology Grand Rounds, Branch Clinical Fellowship, and resident education programs.
Dr. Gadina's research strives to develop cutting-edge immune monitoring technology. His lab develops accurate and reproducible immune-monitoring assays, which are essential to determining the immune responses in patients receiving novel immune therapies, and ultimately transitioning these therapies from the clinical trial phase to standard of care.
Dr. Glancy's research focuses on determining how mitochondria are optimized within muscle cells to help maintain energy homeostasis during the large change in energy demand caused by muscle contraction.
Dr. Gourh is a board-certified rheumatologist with a long-standing interest in scleroderma. He directs a translational research program focused on understanding the genetics of scleroderma, biomarker discovery, and disease classification.
Dr. Hafner's research focuses on dissecting the composition of ribonucleoproteins (RNPs) involved in cellular RNA transport and control of RNA stability. This is a prerequisite for understanding the consequences of dysregulation and/or mutation of RNA-binding proteins (RBPs), and/or their target RNA-binding sites in disease.
Dr. Kaplan's research focuses on unraveling the fundamental mechanisms that lead to the development and perpetuation of systemic autoimmune disorders, particularly systemic lupus erythematosus (SLE) and rheumatoid arthritis (RA), and their associated organ damage.
Dr. Kong's research focuses on the skin microbiome in healthy individuals with the goal of expanding our understanding of host-microbe interactions. Her section also works to understand the role of microbes in eczematous skin diseases, including atopic dermatitis.
Dr. Lewandowski's research studies the genetics of early-onset systemic lupus erythematosus (SLE) patients in populations around the globe and the genetic drivers of severe disease and inflammation in diverse cohorts worldwide.
Dr. Mammen's research focuses on understanding the fundamental mechanisms of disease in different types of myositis, including dermatomyositis, polymyositis, statin-triggered necrotizing myopathy, and inclusion body myositis. The ultimate goal is to establish more effective treatments for patients with all forms of myositis.
Dr. Morasso's research focuses on the molecular processes that contribute to epidermal differentiation and barrier formation, appendage development, and the mechanisms underlying the pathologies of ectodermal dysplasias (EDs)
Dr. Ombrello's research applies integrated genomic approaches to investigate autoinflammatory and rheumatic diseases, seeking to understand the mechanisms through which disease-associated genetic variants participate in disease pathophysiology.
Dr. O'Shea’s research studies how the engagement of cytokine receptors transduce signals that, in turn, regulate transcription factors and epigenetic events to modulate gene expression. Another goal is to understand how T cells participate in host defense and contribute to the pathogenesis of immune-mediated diseases.
Dr. Sartorelli's research focuses on the cellular and molecular mechanisms subtending specification, differentiation, and regeneration of skeletal muscle cells. His lab pursues these studies by combining cellular and molecular biological approaches, genomic and proteomic-based systems-biology, bioinformatics, and animal models.
Dr. Sikora's research focuses on understanding the mechanisms that underlie the development of inflammatory arthritis and cartilage inflammation in children. His unit studies juvenile-onset spondyloarthritis, which often develops into AS, a form of inflammatory arthritis.
Dr. Somerman's research studies the molecular biology of dental-oral-craniofacial development, with a focus on the periodontal complex. The aim is to understand cells and signals influencing tooth, bone, and periodontal ligament development in order to identify improved regenerative strategies.
Dr. Wingfield supports intramural NIH scientists in studying the structure and function of Human Immunodeficiency Virus (HIV) proteins. Most structural biology techniques, especially those for studying the three-dimensional structures of proteins, require large quantities of highly purified, monodisperse, and correctly folded proteins.
Dr. Randazzo focuses on the use of light microscopy techniques to elucidate poorly understood aspects of skeletal muscle cell biology, i.e. the organization of microtubules and their associated subcellular organelles, particularly the Golgi complex. In addition, his section strives to apply new modalities of light microscopy to the quantitative analysis of skeletal muscle pathologies.