Overview

The Cutaneous Microbiome and Inflammation section is focused on studying the skin microbiome in healthy individuals with the goal of expanding our understanding of host-microbe interactions. Previous work has investigated the diversity and distrubution of bacterial and fungal skin communities in healthy adults.

We are also working to understand the role of microbes in eczematous skin diseases, including atopic dermatitis. Our prior work has studied the significant bacterial shifts in the skin of patients with atopic dermatitis as well as patients with primary immunodeficiency syndromes with eczematous skin conditions.

Ongoing Studies

Image & Media Gallery

Scientific Publications

 

 

Topographical and temporal diversity of the human skin microbiome.

Grice EA, Kong HH, Conlan S, Deming CB, Davis J, Young AC, NISC Comparative Sequencing Program., Bouffard GG, Blakesley RW, Murray PR, Green ED, Turner ML, Segre JA
Science (New York, N.Y.).
2009 May 29;
324(5931).
doi: 10.1126/science.1171700
PMID: 19478181

Temporal shifts in the skin microbiome associated with disease flares and treatment in children with atopic dermatitis.

Kong HH, Oh J, Deming C, Conlan S, Grice EA, Beatson MA, Nomicos E, Polley EC, Komarow HD, NISC Comparative Sequence Program., Murray PR, Turner ML, Segre JA
Genome research.
2012 May;
22(5).
doi: 10.1101/gr.131029.111
PMID: 22310478

Shifts in human skin and nares microbiota of healthy children and adults.

Oh J, Conlan S, Polley EC, Segre JA, Kong HH
Genome medicine.
2012;
4(10).
doi: 10.1186/gm378
PMID: 23050952

Topographic diversity of fungal and bacterial communities in human skin.

Findley K, Oh J, Yang J, Conlan S, Deming C, Meyer JA, Schoenfeld D, Nomicos E, Park M, NIH Intramural Sequencing Center Comparative Sequencing Program., Kong HH, Segre JA
Nature.
2013 Jun 20;
498(7454).
doi: 10.1038/nature12171
PMID: 23698366

The altered landscape of the human skin microbiome in patients with primary immunodeficiencies.

Oh J, Freeman AF, NISC Comparative Sequencing Program., Park M, Sokolic R, Candotti F, Holland SM, Segre JA, Kong HH
Genome research.
2013 Dec;
23(12).
doi: 10.1101/gr.159467.113
PMID: 24170601

Staphylococcus aureus and Staphylococcus epidermidis strain diversity underlying pediatric atopic dermatitis.

Byrd AL, Deming C, Cassidy SKB, Harrison OJ, Ng WI, Conlan S, NISC Comparative Sequencing Program., Belkaid Y, Segre JA, Kong HH
Science translational medicine.
2017 Jul 5;
9(397).
pii: eaal4651. doi: 10.1126/scitranslmed.aal4651
PMID: 28679656

Temporal Stability of the Human Skin Microbiome.

Oh J, Byrd AL, Park M, NISC Comparative Sequencing Program., Kong HH, Segre JA
Cell.
2016 May 5;
165(4).
doi: 10.1016/j.cell.2016.04.008
PMID: 27153496

Diverse Human Skin Fungal Communities in Children Converge in Adulthood.

Jo JH, Deming C, Kennedy EA, Conlan S, Polley EC, Ng WI, NISC Comparative Sequencing Program., Segre JA, Kong HH
The Journal of investigative dermatology.
2016 Dec;
136(12).
doi: 10.1016/j.jid.2016.05.130
PMID: 27476723

Biogeography and individuality shape function in the human skin metagenome.

Oh J, Byrd AL, Deming C, Conlan S, NISC Comparative Sequencing Program., Kong HH, Segre JA
Nature.
2014 Oct 2;
514(7520).
doi: 10.1038/nature13786
PMID: 25279917

Topographic diversity of fungal and bacterial communities in human skin.

Findley K, Oh J, Yang J, Conlan S, Deming C, Meyer JA, Schoenfeld D, Nomicos E, Park M, NIH Intramural Sequencing Center Comparative Sequencing Program., Kong HH, Segre JA
Nature.
2013 Jun 20;
498(7454).
doi: 10.1038/nature12171
PMID: 23698366

Latest News

Spotlight on Research | November 5, 2018

Researchers unearth community of viruses on skin of people with rare disease

NIH researchers studied microbial populations in skin samples from 27 adults and children with a rare immune disorder, DOCK8 deficiency.
Last Updated: May 2020