Summary

Dr. Sarfaraz Hasni joined NIAMS in 2009 after completing his fellowship training in Clinical Rheumatology from State University of New York at Stony Brook. After joining NIAMS he completed the NIH-Duke Masters in Clinical Research Program. His research interest in lupus is focused on new biomarker discovery and early phase proof of concept clinical trials.

He has established a collaborative network of rheumatologists, nephrologists, physiatrists and other health care providers interested in lupus clinical research in the Metropolitan DC area called DC Lupus Consortium.

Dr. Hasni is also an active clinician and core faculty of the rheumatology fellowship training program at NIAMS. He has initiated several quality improvement processes to provide excellent clinical care to patients with lupus per the current international guidelines.

Scientific Publications

Brief Report: Deficiency of Complement 1r Subcomponent in Early-Onset Systemic Lupus Erythematosus: The Role of Disease-Modifying Alleles in a Monogenic Disease.

Demirkaya E, Zhou Q, Smith CK, Ombrello MJ, Deuitch N, Tsai WL, Hoffmann P, Remmers EF, Takeuchi M, Park YH, Chae J, Barut K, Simsek D, Adrovic A, Sahin S, Caliskan S, Chandrasekharappa SC, Hasni SA, Ombrello AK, Gadina M, Kastner DL, Kaplan MJ, Kasapcopur O, Aksentijevich I
Arthritis & rheumatology (Hoboken, N.J.).
2017 Sep;
69(9).
doi: 10.1002/art.40158
PMID: 28544690

Multicenter Systems Analysis of Human Blood Reveals Immature Neutrophils in Males and During Pregnancy.

Blazkova J, Gupta S, Liu Y, Gaudilliere B, Ganio EA, Bolen CR, Saar-Dover R, Fragiadakis GK, Angst MS, Hasni S, Aghaeepour N, Stevenson D, Baldwin N, Anguiano E, Chaussabel D, Altman MC, Kaplan MJ, Davis MM, Furman D
Journal of immunology (Baltimore, Md. : 1950).
2017 Mar 15;
198(6).
doi: 10.4049/jimmunol.1601855
PMID: 28179497

Distinct Functions of Autoantibodies Against Interferon in Systemic Lupus Erythematosus: A Comprehensive Analysis of Anticytokine Autoantibodies in Common Rheumatic Diseases.

Gupta S, Tatouli IP, Rosen LB, Hasni S, Alevizos I, Manna ZG, Rivera J, Jiang C, Siegel RM, Holland SM, Moutsopoulos HM, Browne SK
Arthritis & rheumatology (Hoboken, N.J.).
2016 Jul;
68(7).
doi: 10.1002/art.39607
PMID: 26815287

Autoreactive IgE is prevalent in systemic lupus erythematosus and is associated with increased disease activity and nephritis.

Dema B, Pellefigues C, Hasni S, Gault N, Jiang C, Ricks TK, Bonelli MM, Scheffel J, Sacré K, Jablonski M, Gobert D, Papo T, Daugas E, Illei G, Charles N, Rivera J
PloS one.
2014;
9(2).
doi: 10.1371/journal.pone.0090424
PMID: 24587356

miR-150 promotes renal fibrosis in lupus nephritis by downregulating SOCS1.

Zhou H, Hasni SA, Perez P, Tandon M, Jang SI, Zheng C, Kopp JB, Austin H 3rd, Balow JE, Alevizos I, Illei GG
Journal of the American Society of Nephrology : JASN.
2013 Jun;
24(7).
doi: 10.1681/ASN.2012080849
PMID: 23723424
Last Updated: June 2020