Dr. Mammen’s research focuses on human muscle disease as well the basic biology of skeletal muscle regeneration. In particular, his lab aims to understand the fundamental mechanisms of disease in different types of autoimmune muscle disease, including dermatomyositis, polymyositis, and statin-triggered necrotizing myopathy. Furthermore, since his lab has shown that targets of the immune system in myositis play a role in muscle differentiation, ongoing work seeks to further characterize these biological pathways with a view to identifying novel therapeutic targets to promote muscle regeneration.
Chung T, Christopher-Stine L, Paik JJ, Corse A, Mammen AL. The composition of cellular infiltrates in anti-HMG-CoA reductase-associated myopathy. Muscle Nerve. 2015 Aug;52(2):189-95.
Lloyd T, Christopher-Stine L, Pinal-Fernandez I, Tiniakou E, Petri M, Baer A, Danoff S, Pak K, Casciola-Rosen L, and Mammen A. Cytosolic 5’-nucleotidase 1A is a common target of circulating autoantibodies in several autoimmune diseases. Arthritis Care and Research (accepted 2015).
Pinal-Fernandez I, Casciola-Rosen L, Christopher-Stine L, Corse A, and Mammen A. The prevalence of individual histopathologic features varies according to autoantibody status in muscle biopsies from dermatomyositis patients. Journal of Rheumatology (accepted April 2015).