Overview

Principal Investigator

Andrew Mammen, M.D., Ph.D.

As head of the Muscle Disease Unit, Dr. Mammen aims to define pathogenic mechanisms in the various forms of autoimmune myopathy and understand the role of myositis autoantigens in muscle regeneration.

Dr. Mammen’s research focuses on human muscle disease as well the basic biology of skeletal muscle regeneration.  In particular, his lab aims to understand the fundamental mechanisms of disease in different types of autoimmune muscle disease, including dermatomyositis, polymyositis, and statin-triggered necrotizing myopathy.  Furthermore, since his lab has shown that targets of the immune system in myositis play a role in muscle differentiation, ongoing work seeks to further characterize these biological pathways with a view to identifying novel therapeutic targets to promote muscle regeneration.

Scientific Publications

 

 

The composition of cellular infiltrates in anti-HMG-CoA reductase-associated myopathy.

Chung T, Christopher-Stine L, Paik JJ, Corse A, Mammen AL
Muscle & nerve.
2015 Aug;
52(2).
doi: 10.1002/mus.24642
PMID: 25737145

Cytosolic 5'-Nucleotidase 1A As a Target of Circulating Autoantibodies in Autoimmune Diseases.

Lloyd TE, Christopher-Stine L, Pinal-Fernandez I, Tiniakou E, Petri M, Baer A, Danoff SK, Pak K, Casciola-Rosen LA, Mammen AL
Arthritis care & research.
2016 Jan;
68(1).
doi: 10.1002/acr.22600
PMID: 25892010

The Prevalence of Individual Histopathologic Features Varies according to Autoantibody Status in Muscle Biopsies from Patients with Dermatomyositis.

Pinal-Fernandez I, Casciola-Rosen LA, Christopher-Stine L, Corse AM, Mammen AL
The Journal of rheumatology.
2015 Aug;
42(8).

Latest News

Letter from the Director | February 25, 2016

Building Bridges to Enhance Patient Care: The NIAMS Intramural Research Program

The NIAMS Intramural Research Program (IRP), and the entire intramural program at NIH, offer unique resources in the biomedical research enterprise. The long-term, high-risk, high-reward focus of the IRP allows researchers to stretch the boundaries of innovation. They are able to build bridges across the traditional silos that tend to separate organizations, patients and scientists, and research results and clinical practice. These collaborations make an enormous difference for all Americans.
Spotlight on Research | May 15, 2015

Protein Linked to Dermatomyositis Found to Have Role in Regenerating Muscle

Many people with a rare muscle disease called dermatomyositis carry antibodies to a protein called T1F1γ, but the protein’s role in normal and diseased muscle has been elusive. Now, a study led by investigators at the NIH’s National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) provides some insight by showing that T1F1γ has a role in muscle regeneration.

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Last Updated: May 2020