Overview

Principal Investigator

Andrew Mammen, M.D., Ph.D.

As head of the Muscle Disease Unit, Dr. Mammen aims to define pathogenic mechanisms in the various forms of autoimmune myopathy and understand the role of myositis autoantigens in muscle regeneration.

Dr. Mammen’s research focuses on human muscle disease as well the basic biology of skeletal muscle regeneration.  In particular, his lab aims to understand the fundamental mechanisms of disease in different types of autoimmune muscle disease, including dermatomyositis, polymyositis, and statin-triggered necrotizing myopathy.  Furthermore, since his lab has shown that targets of the immune system in myositis play a role in muscle differentiation, ongoing work seeks to further characterize these biological pathways with a view to identifying novel therapeutic targets to promote muscle regeneration.

Contact Us

Nikki Eiland

Sr. Administrative Assistant
9000 Rockville Pike
Building 50, Room 1518
Bethesda MD 20892

Core Research Facilities

Labs at the NIAMS are supported by the following state-of-the-art facilities and services:

Scientific Publications

Selected Recent Publications

Performance of the 2017 EULAR/ACR classification criteria for inflammatory myopathies in patients with myositis-specific autoantibodies.

Casal-Dominguez M, Pinal-Fernandez I, Pak K, Huang W, Selva-O'Callaghan A, Albayda J, Casciola-Rosen L, Paik JJ, Tiniakou E, Mecoli CA, Lloyd TE, Danoff SK, Christopher-Stine L, Mammen AL
Arthritis Rheumatol.
2021 Sep 4;
doi: 10.1002/art.41964
PMID: 34480833

The phenotype of myositis patients with anti-Ku autoantibodies.

Casal-Dominguez M, Pinal-Fernandez I, Derfoul A, Graf R, Michelle H, Albayda J, Tiniakou E, Adler B, Danoff SK, Lloyd TE, Christoper-Stine L, Paik JJ, Mammen AL
Semin Arthritis Rheum.
2021 Aug;
51(4).
doi: 10.1016/j.semarthrit.2021.04.012
PMID: 34144382

Anti-mitochondrial autoantibodies are associated with cardiomyopathy, dysphagia, and features of more severe disease in adult-onset myositis.

Sabbagh SE, Pinal-Fernandez I, Casal-Dominguez M, Albayda J, Paik JJ, Miller FW, Rider LG, Mammen AL, Christopher-Stine L, Johns Hopkins Myositis Center Group.
Clin Rheumatol.
2021 Apr 13;
doi: 10.1007/s10067-021-05730-7
PMID: 33851273

Machine learning algorithms reveal unique gene expression profiles in muscle biopsies from patients with different types of myositis.

Pinal-Fernandez I, Casal-Dominguez M, Derfoul A, Pak K, Miller FW, Milisenda JC, Grau-Junyent JM, Selva-O'Callaghan A, Carrion-Ribas C, Paik JJ, Albayda J, Christopher-Stine L, Lloyd TE, Corse AM, Mammen AL
Ann Rheum Dis.
2020 Sep;
79(9).
doi: 10.1136/annrheumdis-2019-216599
PMID: 32546599

The indirect immunofluorescence assay autoantibody profiles of myositis patients without known myositis-specific autoantibodies.

Casal-Dominguez M, Pinal-Fernandez I, Pak K, Marin-Sanchez A, Sanz-Martinez MT, Baucells A, Hosono Y, Christopher-Stine L, Mammen AL, Johns Hopkins Myositis Center Group.
Clin Exp Rheumatol.
2021 May-Jun;
39(3).

More prominent muscle involvement in patients with dermatomyositis with anti-Mi2 autoantibodies.

Pinal-Fernandez I, Mecoli CA, Casal-Dominguez M, Pak K, Hosono Y, Huapaya J, Huang W, Albayda J, Tiniakou E, Paik JJ, Johnson C, Danoff SK, Corse AM, Christopher-Stine L, Mammen AL
Neurology.
2019 Nov 5;
93(19).
doi: 10.1212/WNL.0000000000008443
PMID: 31594859

Identification of distinctive interferon gene signatures in different types of myositis.

Pinal-Fernandez I, Casal-Dominguez M, Derfoul A, Pak K, Plotz P, Miller FW, Milisenda JC, Grau-Junyent JM, Selva-O'Callaghan A, Paik J, Albayda J, Christopher-Stine L, Lloyd TE, Corse AM, Mammen AL
Neurology.
2019 Sep 17;
93(12).
doi: 10.1212/WNL.0000000000008128
PMID: 31434690

Myositis Autoantigen Expression Correlates With Muscle Regeneration but Not Autoantibody Specificity.

Pinal-Fernandez I, Amici DR, Parks CA, Derfoul A, Casal-Dominguez M, Pak K, Yeker R, Plotz P, Milisenda JC, Grau-Junyent JM, Selva-O'Callaghan A, Paik JJ, Albayda J, Corse AM, Lloyd TE, Christopher-Stine L, Mammen AL
Arthritis Rheumatol.
2019 Aug;
71(8).
doi: 10.1002/art.40883
PMID: 30861336

Pre-existing antiacetylcholine receptor autoantibodies and B cell lymphopaenia are associated with the development of myositis in patients with thymoma treated with avelumab, an immune checkpoint inhibitor targeting programmed death-ligand 1.

Mammen AL, Rajan A, Pak K, Lehky T, Casciola-Rosen L, Donahue RN, Lepone LM, Zekeridou A, Pittock SJ, Hassan R, Schlom J, Gulley JL
Ann Rheum Dis.
2019 Jan;
78(1).
doi: 10.1136/annrheumdis-2018-213777
PMID: 30185415

Key Publications

Statin-Associated Autoimmune Myopathy.

Mammen AL
N Engl J Med.
2016 Feb 18;
374(7).
doi: 10.1056/NEJMra1515161
PMID: 26886523

Intravenous Immune Globulin for Statin-Triggered Autoimmune Myopathy.

Mammen AL, Tiniakou E
N Engl J Med.
2015 Oct 22;
373(17).
doi: 10.1056/NEJMc1506163
PMID: 26488714

Autoantibodies against 3-hydroxy-3-methylglutaryl-coenzyme A reductase in patients with statin-associated autoimmune myopathy.

Mammen AL, Chung T, Christopher-Stine L, Rosen P, Rosen A, Doering KR, Casciola-Rosen LA
Arthritis Rheum.
2011 Mar;
63(3).
doi: 10.1002/art.30156
PMID: 21360500

News & Highlights

Letter from the Director | February 25, 2016

Building Bridges to Enhance Patient Care: The NIAMS Intramural Research Program

The NIAMS Intramural Research Program (IRP), and the entire intramural program at NIH, offer unique resources in the biomedical research enterprise. The long-term, high-risk, high-reward focus of the IRP allows researchers to stretch the boundaries of innovation. They are able to build bridges across the traditional silos that tend to separate organizations, patients and scientists, and research results and clinical practice. These collaborations make an enormous difference for all Americans.
Spotlight on Research | May 15, 2015

Protein Linked to Dermatomyositis Found to Have Role in Regenerating Muscle

Many people with a rare muscle disease called dermatomyositis carry antibodies to a protein called T1F1γ, but the protein’s role in normal and diseased muscle has been elusive. Now, a study led by investigators at the NIH’s National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) provides some insight by showing that T1F1γ has a role in muscle regeneration.
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Last Updated: September 2021 Back to Top