Summary

Dr. Vittorio Sartorelli received his M.D. from the University of Brescia, Italy and did a residency in oncology at the University of Milan, Italy. He joined the Genetics Department and the Department of Medicine of the Stanford University for his postdoctoral education. In 1993, he joined the Department of Biochemistry and Molecular Biology of the Keck School of Medicine, University of Southern California as an Assistant Professor and was recruited in 1999 at the National Institutes of Health to head the Muscle Gene Expression Group within the Laboratory of Muscle Biology of the Intramural Program at the NIAMS. He is currently the Chief of the Laboratory of Muscle Stem Cells & Gene Regulation and NIAMS Deputy Scientific Director.

Research Statement

The Laboratory of Muscle Stem Cells & Gene Regulation focuses on the cellular and molecular mechanisms regulating specification, differentiation, and regeneration of skeletal muscle cells. The objective is to provide a conceptual and practical framework contributing to the diagnosis and treatment of human diseases affecting skeletal muscles. Specific areas of investigation are: 1) transcriptional control of the regulatory circuitries involved in different aspects of adult muscle stem cell biology, 2) functional relation of metabolites and epigenetic modifications impacting adult muscle stem cell biology, 3) role of non-coding RNAs in skeletal muscle biology.

Scientific Publications

Roles of H3K27me2 and H3K27me3 Examined during Fate Specification of Embryonic Stem Cells.

Juan AH, Wang S, Ko KD, Zare H, Tsai PF, Feng X, Vivanco KO, Ascoli AM, Gutierrez-Cruz G, Krebs J, Sidoli S, Knight AL, Pedersen RA, Garcia BA, Casellas R, Zou J, Sartorelli V
Cell reports.
2016 Oct 25;
17(5).
doi: 10.1016/j.celrep.2016.09.087
PMID: 27783950

The Histone Variant MacroH2A1.2 Is Necessary for the Activation of Muscle Enhancers and Recruitment of the Transcription Factor Pbx1.

Dell'Orso S, Wang AH, Shih HY, Saso K, Berghella L, Gutierrez-Cruz G, Ladurner AG, O'Shea JJ, Sartorelli V, Zare H
Cell reports.
2016 Feb 9;
14(5).
doi: 10.1016/j.celrep.2015.12.103
PMID: 26832413

Metabolic Reprogramming of Stem Cell Epigenetics.

Ryall JG, Cliff T, Dalton S, Sartorelli V
Cell stem cell.
2015 Dec 3;
17(6).
doi: 10.1016/j.stem.2015.11.012
PMID: 26637942

The NAD(+)-dependent SIRT1 deacetylase translates a metabolic switch into regulatory epigenetics in skeletal muscle stem cells.

Ryall JG, Dell'Orso S, Derfoul A, Juan A, Zare H, Feng X, Clermont D, Koulnis M, Gutierrez-Cruz G, Fulco M, Sartorelli V
Cell stem cell.
2015 Feb 5;
16(2).
doi: 10.1016/j.stem.2014.12.004
PMID: 25600643

eRNAs promote transcription by establishing chromatin accessibility at defined genomic loci.

Mousavi K, Zare H, Dell'orso S, Grontved L, Gutierrez-Cruz G, Derfoul A, Hager GL, Sartorelli V
Molecular cell.
2013 Sep 12;
51(5).
doi: 10.1016/j.molcel.2013.07.022
PMID: 23993744

Polycomb protein Ezh1 promotes RNA polymerase II elongation.

Mousavi K, Zare H, Wang AH, Sartorelli V
Molecular cell.
2012 Jan 27;
45(2).
doi: 10.1016/j.molcel.2011.11.019
PMID: 22196887

Education

University of Brescia, Italy
M.D.

University of Milan, Italy
Specialty in Oncology

Experience

Chief
Laboratory of Muscle Stem Cells & Gene Regulation, NIAMS, NIH

Group Leader
Laboratory of Muscle Biology, NIAMS, NIH

Postdoctoral Fellow
Stanford University

Assistant Professor
Department of Biochemistry and Molecular Biology
University of Southern California, Los Angeles

 

Last Updated: June 2020