Dr. Vittorio Sartorelli received his M.D. from the University of Brescia, Italy and completed a residency in oncology at the University of Milan, Italy. He joined the Genetics Department and the Department of Medicine of the Stanford University for his postdoctoral education. In 1993, he joined the Department of Biochemistry and Molecular Biology of the Keck School of Medicine, University of Southern California as an Assistant Professor. In 1999, he was recruited to head the Muscle Gene Expression Group within the Laboratory of Muscle Biology of the Intramural Program at the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) within the National Institutes of Health. He is currently the Chief of the Laboratory of Muscle Stem Cells & Gene Regulation and the NIAMS Deputy Scientific Director.
The Laboratory of Muscle Stem Cells & Gene Regulation focuses on the cellular and molecular mechanisms regulating specification, differentiation, and regeneration of skeletal muscle cells. The objective is to provide a conceptual and practical framework contributing to the diagnosis and treatment of human diseases affecting skeletal muscles. Specific areas of investigation are: 1) transcriptional control of the regulatory circuitries involved in different aspects of adult muscle stem cell biology, 2) functional relation of metabolites and epigenetic modifications impacting adult muscle stem cell biology, 3) role of non-coding RNAs in skeletal muscle biology.