Ankylosing Spondylitis

What is ankylosing spondylitis? It is arthritis that affects the spine, usually producing redness, heat, swelling, and pain in the spine where it joins the pelvis.


Arthritis is joint inflammation that can cause stiffness or pain. Learn more about the symptoms & treatments.

Autoimmune Diseases

What are autoimmune diseases? These diseases occur when your immune cells attack your body by mistake. These diseases can affect almost any part of the body.

Autoinflammatory Diseases

What are autoinflammatory diseases? They cause your immune cells to attack your body by mistake, and can cause fever, rash, joint swelling, and more.


What is gout? It is a kind of arthritis that causes painful and stiff joints. Gout is caused by the build-up of crystals of uric acid in your joints.

Hip Replacement Surgery

Hip replacement surgery removes damaged or diseased parts of a hip joint and replaces them with new, artificial parts.

Juvenile Idiopathic Arthritis (JIA)

Juvenile arthritis describes arthritis in children. Arthritis is caused by inflammation of the joints. Find out all you need to know about juvenile arthritis.


What is osteoarthritis? It damages the slippery tissue that covers the ends of bones, causing bones to rub together, producing pain, swelling, and loss of motion.

Polymyalgia Rheumatica and Giant Cell Arteritis

Polymyalgia rheumatica and giant cell arteritis are closely linked inflammatory conditions. PMR causes muscle pain and stiffness in the shoulders, upper arms, hip area, and neck. GCA causes headaches, scalp tenderness, jaw pain, and eye problems.

Psoriatic Arthritis

What is psoriatic arthritis? It can occur in people who have psoriasis (scaly red and white patches). It affects the joints and areas where tissues attach to bone.

Reactive Arthritis

What is reactive arthritis? It is caused by an infection and results in joint pain and swelling. You may also have red, swollen eyes and a swollen urinary tract.

Rheumatoid Arthritis

What is rheumatoid arthritis? It is a disease that affects multiple joints, resulting in pain, swelling, and stiffness. Tiredness and fever may also be present.


Scleroderma causes patches of tight, hard skin, but can also harm your blood vessels and organs. Learn the causes and treatments of this skin disease.

Sjögren’s Syndrome

What is Sjögren’s syndrome? It is a disease that affects the glands that make moisture. It most often causes dryness in the mouth and eyes.

Systemic Lupus Erythematosus (Lupus)

Lupus is a disease where the body's defense system attacks healthy cells and tissues, causing damage to many parts of the body. Learn more about this disease.

Selected Research Areas

Translational Genetics and Genomics Section

Led by Dr. Michael Ombrello, the section uses genomic approaches to understand the underlying factors of autoinflammatory and rheumatic diseases.

Arthritis and Rheumatic Disease News

Roundtable | November 1, 2022

Health Disparities in Osteoarthritis Workshop – July 12-13, 2022


The Health Di

Letter from the Director | June 7, 2022

NIAMS, NIH Seek to Better Understand Arthritis in Native American Communities

The recent observance in May of National Arthritis Awareness Month offered us a chance to reflect on a sizable component of the NIAMS mission area. Arthritis impacts the lives of nearly 60 million Americans. However, a recent conversation with David Wilson, Ph.D., director of NIH’s Tribal Health Research Office, reminded me that arthritis hits some communities harder than others.
Patient and Congressional Visits | June 6, 2022

Roundtable Discussion on Lupus with Congresswoman Lee

Video of a Facebook Live discussion on lupus research, treatment, and care, moderated by Rev. Cheryl Ward and featuring experts in the field.
Spotlight on Research | May 25, 2022

Discussing Bone, Muscle, Skin, & Autoimmune Diseases: Info for American Indians, Alaska Natives - audio

A conversation between Dr. David R. Wilson, director of the NIH Tribal Health Research Office, and Dr. Lindsey A. Criswell, director of NIAMS, about information and resources for American Indians and Alaska Natives related to bone, muscle, skin, and autoimmune diseases.
Spotlight on Research | November 23, 2021

New treatment shows promise in reducing the risk of cardiovascular disease in people with lupus

Researchers have identified a potential treatment to reduce the risk of cardiovascular disease in people with systemic lupus erythematosus (SLE), a chronic autoimmune disease.
Announcement | August 19, 2020

NIH Offers Web-Based Tool to Study Gene Expression in Human Neutrophils

NIH scientists developed and recently released a free, online data query tool called NeutGX. Researchers around the world can use NeutGX to explore the genetic basis of neutrophil-mediated inflammation in autoimmune diseases, cancer, infectious diseases and other conditions.
Last Updated: January 2022