The overall mission of the Biodata Mining and Discovery Section is to assist and to participate in biomedical research with Data Science and Bioinformatics approaches in support of the ultimate research goals of the NIAMS IRP. We are currently integrating NGS data processing and data analysis related computational methods into a wide range of biological and biomedical studies, focusing on WES, ChIP-Seq, ATAC-Seq, RNA-Seq, and Single Cell RNA-Seq based research projects. We also develop new data analysis strategies and customized computational solutions, and conduct research to evaluate emerging methods and techniques in the rapidly evolving field of applied bioinformatics and computational biology.
Callen E, Faryabi RB, Luckey M, Hao B, Daniel JA, Yang W, Sun HW, Dressler G, Peng W, Chi H, Ge K, Krangel MS, Park JH, Nussenzweig A. The DNA Damage- and Transcription-Associated Protein Paxip1 Controls Thymocyte Development and Emigration. Immunity. 2012 Nov 13. pii: S1074-7613(12)00456-6. doi: 10.1016/j.immuni.2012.10.007.
Vahedi G, Takahashi H, Nakayamada S, Sun HW, Sartorelli V, Kanno Y, O'Shea JJ. STATs Shape the Active Enhancer Landscape of T Cell Populations. Cell. 2012 Nov 21;151(5):981-93. doi: 10.1016/j.cell.2012.09.044.
Okano J, Levy C, Lichti U, Sun HW, Yuspa SH, Sakai Y, Morasso MI. Cutaneous retinoic Acid levels determine hair follicle development and downgrowth. J Biol Chem. 2012 Nov 16;287(47):39304-15. doi: 10.1074/jbc.M112.397273. Epub 2012 Sep 24.
Iwata S, Mikami Y, Sun HW, Brooks SR, Jankovic D, Hirahara K, Onodera A, Shih HY, Kawabe T, Jiang K, Nakayama T, Sher A, O'Shea JJ, Davis FP, Kanno Y. The Transcription Factor T-bet Limits Amplification of Type I IFN Transcriptome and Circuitry in T Helper 1 Cells. Immunity. 2017 Jun 20;46(6):983-991
Benhalevy D, Gupta SK, Danan CH, Ghosal S, Sun HW, Kazemier HG, Paeschke K, Hafner M, Juranek SA. The Human CCHC-type Zinc Finger Nucleic Acid-Binding Protein Binds G-Rich Elements in Target mRNA Coding Sequences and Promotes Translation. Cell Rep. 2017 Mar 21;18(12):2979-2990
Layh-Schmitt G, Lu S, Navid F, Brooks SR, Lazowick E, Davis KM, Montagna C, Gadina M, Colbert RA. Generation and differentiation of induced pluripotent stem cells reveal ankylosing spondylitis risk gene expression in bone progenitors. Clin Rheumatol. 2017 Jan;36(1):143-154
Palazzo E, Kellett MD, Cataisson C, Bible PW, Bhattacharya S, Sun HW, Gormley AC, Yuspa SH, Morasso MI. A novel DLX3-PKC integrated signaling network drives keratinocyte differentiation. Cell Death Differ. 2017 Apr;24(4):717-730
Shih HY, Sciumè G, Mikami Y, Guo L, Sun HW, Brooks SR, Urban JF Jr, Davis FP, Kanno Y, O'Shea JJ. Developmental Acquisition of Regulomes Underlies Innate Lymphoid Cell Functionality. Cell. 2016 May 19;165(5):1120-1133