The Cutaneous Development and Carcinogenesis Section studies the signaling pathways such as Hedgehog signaling that regulate the development and maintenance of normal skin, and the changes in these signals that occur during the formation of skin cancer. Our investigations include studying the specification and maintenance of cell lineages in the skin, as well as studying the regulation of stem cells in the skin, and using mouse genetics to model carcinogenesis in the skin.
A current focus in the lab is investigating the the neuro-cutaneous interface and the regulation of neuroendocrine cells (Merkel cells) in the skin. We are also analyzing Merkel cell carcinomas, and are developing pre-clinical mouse models for this uncommon but aggressive skin cancer.
Ongoing Clinical Trials
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