Summary

Davide Randazzo, Ph.D., received his B.S. in biological sciences (summa cum laude) in 2005 at the University of Palermo (Italy) discussing a thesis focused on the regulation of muscle-specific transcription factors during early and late muscle cell differentiation. This work continued as Dr. Randazzo earned his doctoral degree as part of a partnership with the University of Palermo and the National Council of Researches, Italy, from 2007 to 2009. In 2010, he moved to the University of Siena for a postdoctoral position where he characterized a mouse model knockout for the muscle protein Obscurin. In 2014, he moved to U.S. for a position as a visiting fellow at the NIAMS.

Research Statement

Dr. Randazzo's research focuses on: skeletal muscle physiology; structural organization of the sarcomere in striated muscles; organization and function of the microtubule cytoskeleton in healthy and diseased skeletal muscle fibers; and Duchenne muscular dystrophy and related murine models.

Scientific Publications

The kelch protein NS1-BP interacts with alpha-enolase/MBP-1 and is involved in c-Myc gene transcriptional control.

Perconti G, Ferro A, Amato F, Rubino P, Randazzo D, Wolff T, Feo S, Giallongo A
Biochimica et biophysica acta.
2007 Dec;
1773(12).

Obscurin is required for ankyrinB-dependent dystrophin localization and sarcolemma integrity.

Randazzo D, Giacomello E, Lorenzini S, Rossi D, Pierantozzi E, Blaauw B, Reggiani C, Lange S, Peter AK, Chen J, Sorrentino V
The Journal of cell biology.
2013 Feb 18;
200(4).
doi: 10.1083/jcb.201205118
PMID: 23420875

The KSR2-calcineurin complex regulates STIM1-ORAI1 dynamics and store-operated calcium entry (SOCE).

Giurisato E, Gamberucci A, Ulivieri C, Marruganti S, Rossi E, Giacomello E, Randazzo D, Sorrentino V
Molecular biology of the cell.
2014 Jun;
25(11).
doi: 10.1091/mbc.E13-05-0292
PMID: 24672054

Organization of junctional sarcoplasmic reticulum proteins in skeletal muscle fibers.

Barone V, Randazzo D, Del Re V, Sorrentino V, Rossi D
Journal of muscle research and cell motility.
2015 Dec;
36(6).
doi: 10.1007/s10974-015-9421-5
PMID: 26374336

Human pericytes isolated from adipose tissue have better differentiation abilities than their mesenchymal stem cell counterparts.

Pierantozzi E, Badin M, Vezzani B, Curina C, Randazzo D, Petraglia F, Rossi D, Sorrentino V
Cell and tissue research.
2015 Sep;
361(3).
doi: 10.1007/s00441-015-2166-z
PMID: 25820673

Tissue-Specific Cultured Human Pericytes: Perivascular Cells from Smooth Muscle Tissue Have Restricted Mesodermal Differentiation Ability.

Pierantozzi E, Vezzani B, Badin M, Curina C, Severi FM, Petraglia F, Randazzo D, Rossi D, Sorrentino V
Stem cells and development.
2016 May 1;
25(9).
doi: 10.1089/scd.2015.0336
PMID: 26956507

Exercise-induced alterations and loss of sarcomeric M-line organization in the diaphragm muscle of obscurin knockout mice.

Randazzo D, Blaauw B, Paolini C, Pierantozzi E, Spinozzi S, Lange S, Chen J, Protasi F, Reggiani C, Sorrentino V
American journal of physiology. Cell physiology.
2017 Jan 1;
312(1).
doi: 10.1152/ajpcell.00098.2016
PMID: 27784675

The potential of obscurin as a therapeutic target in muscle disorders.

Randazzo D, Pierantozzi E, Rossi D, Sorrentino V
Expert opinion on therapeutic targets.
2017 Sep;
21(9).
doi: 10.1080/14728222.2017.1361931
PMID: 28756711

Persistent upregulation of the β-tubulin tubb6, linked to muscle regeneration, is a source of microtubule disorganization in dystrophic muscle.

Randazzo D, Khalique U, Belanto JJ, Kenea A, Talsness DM, Olthoff JT, Tran MD, Zaal KJ, Pak K, Pinal-Fernandez I, Mammen AL, Sackett D, Ervasti JM, Ralston E
Human molecular genetics.
2019 Apr 1;
28(7).
doi: 10.1093/hmg/ddy418
PMID: 30535187

Misplaced Golgi Elements Produce Randomly Oriented Microtubules and Aberrant Cortical Arrays of Microtubules in Dystrophic Skeletal Muscle Fibers.

Oddoux S, Randazzo D, Kenea A, Alonso B, Zaal KJM, Ralston E
Frontiers in cell and developmental biology.
2019;
7().
doi: 10.3389/fcell.2019.00176
PMID: 31620435

Education

University of Palermo (Italy) and National Council of Researches (Italy)
Ph.D., 2009

University of Palermo (Italy)
B.S., Biological Sciences, 2005, summa cum laude

Experience

Visiting Fellow
Light Imaging Section / Office of Science and Technology, NIAMS, NIH, 2014 - present

Postdoctoral Fellow
University of Siena (Italy), 2010-2014

Last Updated: July 2020