Summary

Mariana Kaplan, M.D., joined the NIAMS as Chief of the Systemic Autoimmunity Branch in 2013. Prior to her appointment, she was Professor of Medicine in the Division of Rheumatology at the University of Michigan. Dr. Kaplan obtained her medical degree at the National Autonomous University of Mexico and did her Internal Medicine Residency at the National Institute of Medical Sciences and Nutrition in Mexico City. Dr. Kaplan did her Rheumatology Fellowship and postdoctoral training at the University of Michigan, where she was a member of the faculty for 15 years, and an active member of their Multidisciplinary Lupus Clinic.

Research Statement

Dr. Kaplan's research has focused on identifying mechanisms of organ damage and premature vascular disease in systemic autoimmunity. More specifically, she investigates how innate immunity (in particular, type I interferons and myeloid cells) promote end-organ damage in systemic lupus erythematosus, rheumatoid arthritis and other systemic autoimmune diseases. Recently, her research has focused on identifying abnormalities of neutrophil subsets and the role of neutrophil extracellular traps (NETs) in lupus and rheumatoid arthritis, both of which may contribute to the development of autoimmune responses and to end-organ damage. Dr. Kaplan also has an interest in identifying novel therapeutic targets that may prevent premature vascular damage in systemic autoimmunity, as well as the role of environmental triggers in the induction of autoimmunity. Moreover, she has led clinical trials to identify mechanisms that reduce blood vessel dysfunction in autoimmune and chronic inflammatory disorders.

In addition to her research activities, Dr. Kaplan is an active clinician and teacher. She sees lupus patients in the NIH Clinical Research Center and is involved in the development of various clinical trials for patients with autoimmune diseases at NIH. She has served in various roles at the American College of Rheumatology/Rheumatology Research Foundation, the American Association of Immunologists, the Journal of Immunology, and the Lupus Foundation of America. She was elected to the American Society for Clinical Investigation and the Association of American Physicians, and received the Henry Kunkel Young Investigator Award and the Edmund L. Dubois Memorial Lectureship, both from the American College of Rheumatology. Dr. Kaplan received the 2015 Evelyn V. Hess Award from the Lupus Foundation of America in recognition of her significant contributions to lupus research, diagnosis, and treatment.

Scientific Publications

CD11b activation suppresses TLR-dependent inflammation and autoimmunity in systemic lupus erythematosus.

Faridi MH, Khan SQ, Zhao W, Lee HW, Altintas MM, Zhang K, Kumar V, Armstrong AR, Carmona-Rivera C, Dorschner JM, Schnaith AM, Li X, Ghodke-Puranik Y, Moore E, Purmalek M, Irizarry-Caro J, Zhang T, Day R, Stoub D, Hoffmann V, Khaliqdina SJ, Bhargava P, Santander AM, Torroella-Kouri M, Issac B, Cimbaluk DJ, Zloza A, Prabhakar R, Deep S, Jolly M, Koh KH, Reichner JS, Bradshaw EM, Chen J, Moita LF, Yuen PS, Li Tsai W, Singh B, Reiser J, Nath SK, Niewold TB, Vazquez-Padron RI, Kaplan MJ, Gupta V
The Journal of clinical investigation.
2017 Apr 3;
127(4).
doi: 10.1172/JCI88442
PMID: 28263189

Neutrophil extracellular traps enriched in oxidized mitochondrial DNA are interferogenic and contribute to lupus-like disease.

Lood C, Blanco LP, Purmalek MM, Carmona-Rivera C, De Ravin SS, Smith CK, Malech HL, Ledbetter JA, Elkon KB, Kaplan MJ
Nature medicine.
2016 Feb;
22(2).
doi: 10.1038/nm.4027
PMID: 26779811

Peptidylarginine deiminase inhibition reduces vascular damage and modulates innate immune responses in murine models of atherosclerosis.

Knight JS, Luo W, O'Dell AA, Yalavarthi S, Zhao W, Subramanian V, Guo C, Grenn RC, Thompson PR, Eitzman DT, Kaplan MJ
Circulation research.
2014 Mar 14;
114(6).
doi: 10.1161/CIRCRESAHA.114.303312
PMID: 24425713

Peptidylarginine deiminase inhibition is immunomodulatory and vasculoprotective in murine lupus.

Knight JS, Zhao W, Luo W, Subramanian V, O'Dell AA, Yalavarthi S, Hodgin JB, Eitzman DT, Thompson PR, Kaplan MJ
The Journal of clinical investigation.
2013 Jul;
123(7).
doi: 10.1172/JCI67390
PMID: 23722903

NETs are a source of citrullinated autoantigens and stimulate inflammatory responses in rheumatoid arthritis.

Khandpur R, Carmona-Rivera C, Vivekanandan-Giri A, Gizinski A, Yalavarthi S, Knight JS, Friday S, Li S, Patel RM, Subramanian V, Thompson P, Chen P, Fox DA, Pennathur S, Kaplan MJ
Science translational medicine.
2013 Mar 27;
5(178).
doi: 10.1126/scitranslmed.3005580
PMID: 23536012

Synovial fibroblast-neutrophil interactions promote pathogenic adaptive immunity in rheumatoid arthritis.

Carmelo Carmona-Rivera, Erica Moore, Nithya Lingampalli, Hannes Uchtenhagen, Eddie James, Kevin L. Bicker, Heidi Wähämaa, Victoria Hoffmann, Anca I Catrina, Paul Thompson, Jane H. Buckner, William Robinson, David Fox and Mariana Kaplan

Education

Universidad Nacional Autonoma de Mexico, School of Medicine, Mexico City, Mexico
M.D.

Experience

House Officer
Internal Medicine, Instituto Nacional de Ciencias Medicas y de la Nutricion Salvador Zubiran, National Institutes of Health, Mexico City, Mexico

Fellow
Division of Rheumatology, University of Michigan

Lecturer/Research Fellow
Division of Rheumatology, University of Michigan

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