Vasculitis is a family of rare diseases defined by inflammation in blood vessels. These conditions, if not quickly recognized and properly treated, can cause serious and life-threatening damage to multiple organ systems. The goal of the Vasculitis Translational Research Program (VTRP) is to discover factors that cause vasculitis and to develop novel ways for physicians to diagnose and monitor these diseases more effectively.
Tremendous progress over the last few decades has transformed vasculitis from frequently fatal into a chronic, manageable illness. However, treatment with potentially toxic medications, including steroids and other medications that suppress the immune system, is generally required to induce remission. Although most patients with vasculitis achieve remission with treatment, the majority of patients experience one or more recurrences of the disease. Disease relapse can result in additional permanent organ damage and can be fatal. At present, we have a very crude understanding of what causes vasculitis. There are very few tests available that reliably help a doctor predict which patients will experience a relapsing disease course. The identification of factors that cause vasculitis and the discovery of biomarkers that can predict clinical outcomes and guide patient-specific therapeutic decisions is the major focus of the VTRP.
The VTRP was established in 2013 to evaluate patients with known vasculitis or with clinical suspicion of vasculitis. Diseases of interest include Takayasu’s arteritis (TAK), relapsing polychondritis (RP), giant cell arteritis (GCA), granulomatosis with polyangiitis (GPA), microscopic polyangiitis (MPA), eosinophilic granulomatosis with polyangiitis (EGPA), and polyarteritis nodosa (PAN) among other types of vasculitis.
A selection of our current projects are as follows:
- Vascular Imaging in Large-Vessel Vasculitis
- Takayasu’s arteritis and giant cell arteritis are the two major diseases that affect the aorta and its primary branches. The detection of active vasculitis is important to prevent the progression of vascular disease and organ damage; however, clinical assessment of disease activity is challenging. Although vascular imaging is considered essential in these diseases, there are no accepted guidelines for imaging and prospective imaging data is lacking. Our group has employed advanced molecular imaging techniques in patients with large-vessel vasculitis to study whether serial imaging has diagnostic and prognostic value in addition to monitoring utility. We discovered that the majority of patients with large-vessel vasculitis have evidence of ongoing vascular inflammation by FDG-PET scans during periods of apparent clinical remission and that the degree of vascular inflammation seen during clinical remission predicts future relapse. We developed and validated PETVAS, a quantitative measure of vascular inflammation that is being used internationally as an outcome measure in ongoing clinical trials. Our lab is working to define a potential immunologic basis for subclinical inflammation in these conditions.
- Relapsing Polychondritis
- Our group recently established the largest prospective cohort of relapsing polychondritis. The NIH RP program currently has recruited >100 patients with relapsing polychondritis. Patients are evaluated at 6-month intervals using a standardized assessment protocol with biobanking of research samples. From these efforts, we have published some of the only observational cohort data in relapsing polychondritis. Using latent class analysis, we have defined three major clinical subsets of RP based on the pattern of organ involvement. and are using these subsets as the framework to investigate causal disease factors, treatment approaches, and potential biomarkers. Recently, in collaboration with the Kastner lab, we have discovered a genetic factor that is causal in 8% of patients with relapsing polychondritis.
- Neutrophil Biology in Small and Medium-Vessel Vasculitis
- Neutrophils are key cells that drive inflammation in many forms of vasculitis. Our group has partnered with the Kaplan Lab in the Systemic Autoimmunity Branch to study novel aspects of neutrophil biology and innate immune system involvement in ANCA-associated vasculitis, drug-induced vasculitis, and monogenic vasculitis. Through these efforts, we have learned that a subset of neutrophils known as low-density granulocytes may play a pathogenic role in ANCA-associated vasculitis, that cholinergic receptors on neutrophils mediate disease in levamisole-induced vasculitis, and that the adenosine-mediated activation of neutrophils contributes to inflammation in deficiency in deaminase 2 (DADA2).
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Studies Seeking Patients
ClinicalTrials.gov Identifier: NCT02257866
Patients with vasculitis or with a suspicion of vasculitis may be eligible to participate in this ongoing research study conducted by the NIAMS Vasculitis Translational Research Program.
To participate, patients may either
- Provide a mail-in blood sample for genetic studies.
- Travel to the National Institutes of Health in Bethesda, MD for a comprehensive evaluation.
Participation in our research program typically entails:
- Comprehensive clinical evaluation by our team of specialists and treatment recommendations. We will communicate with your local doctors about our findings and will remain available over time to help with questions about your care.
- Donation of blood samples for research.
- For patients with large-vessel vasculitis, we regularly perform advanced imaging to visualize your arteries, which includes FDG-PET scans to assess vascular inflammation.
- For patients with relapsing polychondritis, we work closely with our colleagues in Otolaryngology to evaluate your airway.
How to get involved:
- Patients with vasculitis or their physicians should contact our team research nurse Elaine Novakovich at 301-451-1450 or via email email@example.com
- Patients with relapsing polychondritis or their physicians should contact our team research nurse Wendy Goodspeed at 301-451-6761 or via email firstname.lastname@example.org
ClinicalTrials.gov Identifier: NCT04690816
Viral infections such as COVID-19 may lead to flare-ups in people with systemic autoimmune diseases (SAD). These infections may also change the function of their immune system and/or cause problems with their blood vessels. Researchers want to learn how people with SAD respond to treatments or vaccines for COVID-19. The objective of this study is to understand how COVID-19 affects inflammation, the immune system, and blood vessels in adults and children with autoimmune diseases.