Overview

Principal Investigator

Peter Grayson, M.D., M.Sc.

Peter Grayson's research interests include clinical and translational research in vasculitis with a focus on biomarker discovery, gene expression profiling, clinical trials, and disease classification.

The goal of the Vasculitis Translational Research Program (VTRP) is to develop clinical and translational research initiatives across many types of systemic vasculitis. Vasculitis is a family of rare diseases characterized by inflammation within blood vessels. Tremendous progress over the last few decades has transformed vasculitis from frequently fatal into a chronic illness. However, treatment with potentially toxic medications, including glucocorticoids and other immune suppressants such as cyclophosphamide, is generally required to induce remission. Although most patients with vasculitis achieve remission with treatment, the majority of patients experience one or more relapses. Relapses often result in additional permanent organ damage and can be fatal. Currently, there are few known predictors of relapse in vasculitis, and there are no known predictors to reliably guide treatment decisions. The identification of novel therapeutic targets and of biomarkers that predict clinical outcomes to guide patient-specific therapeutic decisions is a major focus of the VTRP.

The VTRP was established in 2013 to evaluate patients with known vasculitis or with clinical suspicion of vasculitis. Diseases of interest include granulomatosis with polyangiitis (GPA, Wegener’s), microscopic polyangiitis (MPA), eosinophilic granulomatosis with polyangiitis (EGPA, Churg-Strauss), polyarteritis nodosa (PAN), giant cell arteritis (GCA), Takayasu’s arteritis (TAK), and idiopathic aortitis among other types of vasculitis.

Some of the objectives of the VTRP include:

  • Comprehensive clinical evaluation and treatment recommendations for all patients within the program.
  • Novel imaging studies to assess for vascular inflammation in medium and large vessel vasculitis.
  • Characterization of novel aspects of neutrophil biology in ANCA-associated vasculitis, in collaboration with the NIAMS Systemic Autoimmunity Branch (Kaplan Lab).
  • Discovery of novel biomarkers in peripheral blood and tissue through whole-genome gene expression profiling and other high-throughput techniques.
  • Clinical trials of novel therapeutics in small, medium, and large vessel vasculitis.
  • Collaboration with the Vasculitis Clinical Research Consortium.

To participate in the VTRP or to refer a patient, please contact Elaine Novakovich for further details (by phone: 301-451-1450 or email).

Staff

Head
Associate Director NIAMS Fellowship Program
301-827-9187
Postbaccalaureate Fellow
817-791-4288
Special Volunteer
301-451-4362

Image & Media Gallery

Scientific Publications

Grayson PC, Amudala NA, McAlear CA, Leduc RL, Shereff D, Richesson R, Fraenkel L, Merkel PA. Causal Attributions about Disease Onset and Relapse in Patients with Systemic Vasculitis. J Rheumatol. 2014 May;41(5):923-30. doi: 10.3899/jrheum.131096

Mooney J, Spalding N, Poland F, Grayson P, Leduc R, McAlear CA, Richesson RL, Shereff D, Merkel PA, Watts RA. The informational needs of patients with ANCA-associated vasculitis--development of an informational needs questionnaire. Rheumatology (Oxford). 2014 Mar 12. [Epub ahead of print]

Kissin EY, Grayson PC, Cannella AC, Demarco PJ, Evangelisto A, Goyal J, Al Haj R, Higgs J, Malone DG, Nishio MJ, Tabechian D, Kaeley GS. Musculoskeletal ultrasound objective structured clinical examination: an assessment of the test. Arthritis Care Res (Hoboken). 2014 Jan;66(1):2-6

Latest News

Letter from the Director | February 25, 2016

Building Bridges to Enhance Patient Care: The NIAMS Intramural Research Program

The NIAMS Intramural Research Program (IRP), and the entire intramural program at NIH, offer unique resources in the biomedical research enterprise. The long-term, high-risk, high-reward focus of the IRP allows researchers to stretch the boundaries of innovation. They are able to build bridges across the traditional silos that tend to separate organizations, patients and scientists, and research results and clinical practice. These collaborations make an enormous difference for all Americans.
Research Brief | April 27, 2015

Potential Biomarker for Treatment Response in Vasculitis Patients Identified

Scientists have discovered a potential biomarker for predicting which patients with a disease known as ANCA-associated vasculitis (AAV) are more likely to respond to treatment.
Last Reviewed: 02/17/2017