CLINICAL

Description

Giant cell arteritis (GCA), also known as temporal arteritis, is an inflammatory disease of the large blood vessels causing chronic inflammation in the aorta and its major branches. Extracellular mitochondria can activate the immune system in free form or enclosed in extracellular vesicles. The authors of this study investigated how extracellular mitochondria contribute to inflammation and platelet activation in people with GCA.

What is exciting about this article?

The extracellular mitochondria can activate the immune system. In this study, the researchers demonstrated that people with GCA have an impaired ability to clear mitochondria, which may contribute to excessive inflammation and platelet activation. It is possible that mitochondrial clearance may reduce inflammation and thrombosis in GCA patients.

Grant support

AR041204

Research Areas:

Autoimmunity Clinical Research Computational Biology Epidemiology Genetics and Genomics Immunology

Reference:

Mitochondrial-mediated inflammation and platelet activation in giant cell arteritis.

Michailidou D, Grayson PC, Hermanson P, Chapa JAG, Cuthbertson D, Khalidi NA, Koening CL, Langford CA, McAlear CA, Moreland LW, Pagnoux C, Seo P, Sreih AG, Warrington KJ, Monach PA, Merkel PA, Lood C
Clin Immunol.
2023 Oct;
255().
doi: 10.1016/j.clim.2023.109746
PMID: 37625669

Research reported in this publication was supported by the Intramural Research Program of the NIHʼs National Institute of Arthritis and Musculoskeletal and Skin Diseases.