Advance description
This study examines how a specific metabolic pathway, called the Aconitate Decarboxylase 1/Itaconate pathway, affects the immune system in people with systemic lupus erythematosus (SLE). The researchers found that this pathway is involved in the immune system dysfunction in animal models of lupus and is also linked to markers that indicate heart disease risk and lupus disease activity levels in people with SLE.
What is exciting about this article?
By better understanding this pathway, researchers could find new ways to treat lupus and reduce the risk of heart disease in people with lupus by modulating metabolic pathways in their immune cells.
Grant support
ZIA AR041199 (Kaplan, Mariana) Systemic Autoimmunity
Research Areas:
Research reported in this publication was supported by the Intramural Research Program of the NIHʼs National Institute of Arthritis and Musculoskeletal and Skin Diseases.