This study is a retrospective review of 18 children with STAT3 dominant negative disease (Job’s syndrome) to examine the different treatments and disease manifestation in those with and without a family history of the disease. Children with a family history had an earlier diagnosis and earlier initiation of prophylactic approaches with significantly reduced infection, hospitalization, and surgery rates, as compared to those without.

What is exciting about this article?

Earlier diagnosis in children with STAT3 dominant negative disease results in earlier interventions, which is linked to less severe disease. Thus, it is important to diagnose these children as early as possible to improve clinical outcomes.

Grant support


Research Areas:

Clinical Research Computational Biology Genetics and Genomics Microbiology and Infectious Diseases Skin Biology


Early intervention in STAT3 dominant negative disease.

An ZA, Williams KW, Urban A, Ali S, Roy S, Lafeer C, Heimall J, Dimitriades VR, Davis J, Kong HH, Cowen EW, Holland SM, Freeman AF
J Allergy Clin Immunol Pract.
2023 Dec;
doi: 10.1016/j.jaip.2023.08.044
PMID: 37683824

Research reported in this publication was supported by the Intramural Research Program of the NIHʼs National Institute of Arthritis and Musculoskeletal and Skin Diseases.