Research Advances
The Wellstone Centers have contributed to over 800 publications spanning basic, translational, and clinical research.
Displaying 401 - 420 of 1016 results
Community Collaboration Advances NIAMS Resource Development
When I joined NIAMS three and a half years ago, I talked about my commitment to collaboration and learning from the NIAMS community in my first director’s letter. Since then, we have done a lot of both collaborating and learning! I highly value the input from the NIAMS community on the development of our resources and in determining the direction of our research so that we are addressing the needs of the various audiences we serve, from researchers and medical providers to patients and caregivers. NIAMS regularly solicits feedback to understand audience needs. Over the past two years, the NIAMS
Emily Rosenbaum, B.A.
https://www.niams.nih.gov/about/directory/emily-rosenbaum-ba
Emily is researching Still’s disease using bioinformatics tools and analyses, explicitly focusing on the rare genetic variants associated with the disease.
Research Career Development Awards: K Awards
The NIH Research Career Development program helps ensure that a pool of highly trained scientists is available in appropriate scientific disciplines to address the Nation's biomedical, behavioral, and clinical research needs.
NIH Pathway to Independence Awards: K99/ R00
The NIH Pathway to Independence Award (K99/R00) program facilitates timely transition of outstanding postdoctoral researchers with a research and/or clinical doctorate degree from mentored, postdoctoral research positions to independent, tenure-track or equivalent faculty positions.
R03 Information for NIAMS K Award Recipients
NIAMS Small Grant Program for New Investigators (R03) Read the NOFO: Limited Competition: Small Grant Program for NIAMS K01, K08, K23, and K25 Recipients (R03) (Clinical Trials Not Allowed) Program Purpose: The National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) is seeking small grant (R03) applications to stimulate
Family Friendly, Trainee, and Early Career Investigator Support
NAMS participates in several programs focused on promoting the continuation and retention of investigators.
NIH Early-Stage Investigator (ESI) and K99 Eligibility Extension Policies
NIH Early-Stage Investigator (ESI) and K99 Eligibility Extension Policies
Gyeongmin Kim, Ph.D.
https://www.niams.nih.gov/about/directory/gyeongmin-kim-phd
Dr. Gyeongmin Kim joined the Systemic Autoimmunity Branch at the NIAMS as a Postdoctoral Fellow in 2024. She works on the pathogenesis of autoinflammatory or autoimmune conditions in systemic lupus erythematosus (SLE).
Researchers Identify a Disease-Causing Immune Cell Imbalance in Lupus
Overview A team of NIAMS-funded researchers discovered an imbalance of T cell subtypes in patients with lupus that contributes to ongoing production of disease-causing autoantibodies. Compared to healthy individuals, patients with lupus have more T cells with specialized B cell helper functions and fewer T cells that are important for wound healing and maintaining the epithelial barrier, which acts to protect the body from pathogens and other invaders. The team identified two molecules that control this imbalance, which could be the targets of lupus treatments in the future. The study was recently published in the journal Nature. Background Systemic lupus
CLINICAL
Nail findings can indicate risk of melanoma cancer syndrome
Scientists at NIAMS and the National Cancer Institute have identified a new clue to the diagnosis of BAP1 TPDS through a study at the NIH Clinical Center in Bethesda, Maryland. Individuals with known mutations in the BAP1gene were enrolled in the study and evaluated for nail abnormalities.
Clinical Research
Skin Biology
CLINICAL
Skin Manifestations of VEXAS Syndrome and Associated Genotypes May Aid in Quicker Diagnosis
A team of researchers in the Dermatology Consultation Service analyzed tissue samples from 60 of 112 study participants who were referred to the NIH Clinical Center in Bethesda, MD, for suspected VEXAS syndrome. The most reported findings included inflammation of the small blood vessels of the skin, known as leukocystoclastic vasculitis, fever and a painful rash known as neutrophilic dermatosis, and inflammation of the skin around the blood vessels, known as perivascular dermatitis.
Clinical Research
Genetics and Genomics
Immunology
Skin Biology
Array of Patient Recruitment Efforts Boost Back Pain Study Participation
Back pain is one of the most common forms of chronic pain affecting adults. People with chronic back pain often take opioids for pain management, but opioids are highly addictive. To address this public health challenge, in 2019 NIH launched the Back Pain Consortium (BACPAC) Research Program, part of the NIH Helping to End Addiction Long-term® (HEAL) Initiative that launched in 2018, a patient-centered effort to address the need for non-addictive, effective and personalized therapies for chronic back pain. Scientists are conducting clinical trials with the hopes of finding new non-opioid treatments. Yet for clinical trials to be effective, the
BASIC
A computational method to improve analysis of single cell RNA-sequencing
In this report, researchers described a deep neural generative framework, the dynamic batching adversarial autoencoder (DB-AAE), which excels at denoising scRNA-seq datasets. DB-AAE directly captures optimal features from input data and enhances feature preservation, including cell type-specific gene expression patterns.
Computational Biology
Genetics and Genomics
BASIC
HLA-B27 does not trigger gut inflammation through the unfolded protein response
Spondyloarthritis (SpA) is an inflammatory disease that affects the gastrointestinal tract, skeleton, and eyes. HLA-B27 is a major risk gene for SpA, but the underlying mechanisms are unclear. One hypothesis is that HLA-B27 promotes SpA through misfolding-induced endoplasmic reticulum (ER) stress that in turn upregulates IL-23 expression via the transcription factor CHOP. In this study, the researchers knocked out CHOP expression in an animal model of HLA-B27-associated SpA. Despite reduced IL-23 production, gut inflammation did not improve, indicating that the gut disease did not occur as a result of ER stress-induced IL-23 production.
Genetics and Genomics
Immunology
Molecular Biology and Biochemistry
CLINICAL
Genetic variants of hemophagocytic lymphohistiocytosis genes are enriched in children with systemic juvenile idiopathic arthritis
Familial hemophagocytic lymphohistiocytosis (HLH) is a life-threatening cytokine storm syndrome caused by recessive, loss of function variants of genes in the pathway that controls the processing of cytolytic granule processing pathway genes. Heterozygous variants in these genes contribute to a secondary form of HLH (macrophage activation syndrome, MAS) that frequently develops in children with systemic juvenile idiopathic arthritis (sJIA). To evaluate the relationship between HLH gene variation and sJIA without MAS, HLH genes were sequenced and compared between 524 patients with sJIA and 2,924 control patients.
Autoimmunity
Genetics and Genomics