Helena Fabryova, M.Sc., Ph.D.

Scientific Program Manager

Career Development and Outreach Branch

Summary

Helena Fabryova, Ph.D., completed her MSc in Molecular Biology in 2013 at the Comenius University in Bratislava (Slovakia) and her Ph.D. in Molecular and Cellular Biology in 2017 in the Genetics and Virology program at the Charles University in Prague (Czech Republic). She studied various topics, including host-virus interactions of endogenous retroviruses and GC-rich chicken genes at the Institute of Molecular Genetics at the Czech Academy of Sciences. She was on the team identifying the oldest endogenous Lentivirus known to date and the first endogenous Deltaretrovirus. The group also performed functional studies on selected genes previously deemed missing in birds due to the highly GC-rich nature of the bird genomes.

She joined the NIH in August 2017 as a visiting fellow and has worked on various projects related to HIV-1 and HIV-2 accessory proteins. Her work focused on studying Vpr and Vpx and their interaction partners. Aside from her benchwork, Dr. Fabryova taught virology and biology courses with FAES and is an adjunct professor of virology and immunobiotechnology at Georgetown University. Dr. Fabryova has always appreciated the support provided during her research career and advocated for trainees. She enjoyed teaching various scientific topics and mentoring trainees in the laboratory. She decided to move into a more administrative role. Dr. Fabryova facilitates a broad range of programming for NIAMS IRP fellows and offers laboratory support services for investigators as a scientific program manager in the NIAMS OSO/Career Development and Outreach Branch (CDOB).

Scientific Publications

HIV-1 Vpr Induces Degradation of Gelsolin, a Myeloid Cell-Specific Host Factor That Reduces Viral Infectivity by Inhibiting the Expression and Packaging of the HIV-1 Env Glycoprotein.

Fabryova H, Kao S, Sukegawa S, Miyagi E, Taylor L, Ferhadian D, Saito H, Schaal H, Hillebrand F, Strebel K
mBio.
2023 Feb 28;
14(1).
doi: 10.1128/mbio.02973-22
PMID: 36602307

Vpr and Its Cellular Interaction Partners: R We There Yet?

Fabryova H, Strebel K
Cells.
2019 Oct 24;
8(11).
doi: 10.3390/cells8111310
PMID: 31652959

Antiviral Activity and Adaptive Evolution of Avian Tetherins.

Krchlíková V, Fábryová H, Hron T, Young JM, Koslová A, Hejnar J, Strebel K, Elleder D
J Virol.
2020 Jun 1;
94(12).
doi: 10.1128/JVI.00416-20
PMID: 32238588

Discovery of an endogenous Deltaretrovirus in the genome of long-fingered bats (Chiroptera: Miniopteridae).

Farkašová H, Hron T, Pačes J, Hulva P, Benda P, Gifford RJ, Elleder D
Proc Natl Acad Sci U S A.
2017 Mar 21;
114(12).
doi: 10.1073/pnas.1621224114
PMID: 28280099

Life History of the Oldest Lentivirus: Characterization of ELVgv Integrations in the Dermopteran Genome.

Hron T, Farkašová H, Padhi A, Pačes J, Elleder D
Mol Biol Evol.
2016 Oct;
33(10).
doi: 10.1093/molbev/msw149
PMID: 27507840

Induction and characterization of a replication competent cervid endogenous gammaretrovirus (CrERV) from mule deer cells.

Fábryová H, Hron T, Kabíčková H, Poss M, Elleder D
Virology.
2015 Nov;
485().
doi: 10.1016/j.virol.2015.07.003
PMID: 26218214

Education

Charles University in Prague, Czech Republic 
Ph.D. Molecular and Cellular Biology, Genetics and Virology (2013-2017) 

Comenius University in Bratislava, Slovakia 
M.Sc in Molecular Biology (2011-2013) 

Comenius University in Bratislava, Slovakia 
B.S. in Biology (2008-2011)

Experience

Research Fellow 
Viral Biochemistry Section, Laboratory of Molecular Microbiology, NIAID, NIH (2022-2024) 

Lead Instructor and co-instructor for various virology and molecular biology classes 
FAES (2019-2022)

Visiting Fellow 
Viral Biochemistry Section, Laboratory of Molecular Microbiology, NIAID, NIH (2017-2022)

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