Rheumatoid Arthritis: Joint-Specific Cell Differences Suggest the Need for Tailored Therapies


A new study, funded in part by the NIH’s National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS), has uncovered differences in key cellular processes between knee and hip joints of people with rheumatoid arthritis (RA). The findings, which appeared in the journal, Nature Communications, suggest that tailoring RA medications to the affected joints in each individual could improve effectiveness and bring greater relief from symptoms. RA is an autoimmune disorder in which the immune system, which normally protects the body, mistakenly attacks the joints, causing inflammation and pain. If unchecked, the disease can erode the cartilage and bone

Engineered T Cells Alleviate Autoimmune Skin Disease in Mice


A new study, funded in part by the NIH’s National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS), has shown that engineered T cells can destroy antibody-producing cells that underlie a rare autoimmune disorder of the skin. The findings, which appeared in the journal Science, offer a new strategy for treating the disease, pemphigus vulgaris (PV), and possibly certain other autoimmune conditions as well. PV occurs when the immune system, which normally protects the body, attacks normal proteins that link cells to one another in the skin’s outer layer. Without these tethers, the cells separate, resulting in chronic blistering

Showcasing NIAMS Research in Action for Key Stakeholders


Dear Colleagues: A key part of the NIAMS mission is keeping our stakeholders informed of the accomplishments made possible through the investment of the American peoples’ tax dollars in biomedical research, and how that research is improving the lives of people living with diseases and conditions of the bones, joints, muscles and skin. NIAMS interacts with multiple groups, including investigators and grantees, and professional and voluntary organizations that represent the interests of scientists, medical practitioners and patients. Another important group that we interact with frequently is Congressional staff. Individual policymakers often approach the Institute when they need specific information about

NIAMS Community Health Clinic Moves to Campus


Fifteen years ago, NIAMS established its Community Health Clinic (CHC) as an extension of the NIH Rheumatology Clinical Research Program to better understand diseases such as rheumatoid arthritis and lupus and gain insights about why these and other rheumatic diseases disproportionately affect people in certain minority groups. The full-service rheumatology clinic, which has enrolled more than 2,500 patients and provided nearly 17,000 patient visits since its inception, recently relocated to the Clinical Center, enabling individuals enrolled in the “Natural History of Rheumatic Diseases in Minority Communities” protocol to receive patient care services from a centralized state-of-the-art facility. When it opened

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