Summary

Dr. Natasha Hill is a research fellow in the Cutaneous Development and Carcinogenesis Section of the Dermatology Branch. She has presented her research at numerous national and international meetings. And has received awards for her work in both the iron metabolism field and skin cancer field.

Research Statement

Dr. Hill’s current research uses genomic and proteomic techniques to investigate the pathobiology of Merkel cell carcinoma (MCC), a neuroendocrine skin cancer that predominantly occurs in elderly and immunosuppressed populations. MCC is a rare but aggressive cancer, which is need of effective treatments for advanced disease. Her current project identifies genomic structural variants using high-density array Comparative Genomic Hybridization (aCGH) and Nanostring copy number variant technologies. Following variant validation, she will explore the role of implicated target genes in the development and progression of MCC, such as studying the role of the Golgi apparatus in MCC. By elucidating the Golgi mechanisms that promote survival pathways, she hopes to identify therapeutic targets and development novel therapies for MCC.

Scientific Publications

1α, 25-Dihydroxyvitamin D₃ and the vitamin D receptor regulates ΔNp63α levels and keratinocyte proliferation.

Hill NT, Zhang J, Leonard MK, Lee M, Shamma HN, Kadakia M
Cell death & disease.
2015 Jun 11;
6().
doi: 10.1038/cddis.2015.148
PMID: 26068789

Role of vitamin D3 in modulation of ΔNp63α expression during UVB induced tumor formation in SKH-1 mice.

Hill NT, Gracia-Maldonado GH, Leonard MK, Harper AR, Tober KL, Oberyszyn TM, Kadakia MP
PloS one.
2014;
9(9).
doi: 10.1371/journal.pone.0107052
PMID: 25191969

ΔNp63α represses nuclear translocation of PTEN by inhibition of NEDD4-1 in keratinocytes.

Leonard MK, Hill NT, Grant ED, Kadakia MP
Archives of dermatological research.
2013 Oct;
305(8).
doi: 10.1007/s00403-013-1352-7
PMID: 23589096

The PTEN-Akt pathway impacts the integrity and composition of mitotic centrosomes.

Leonard MK, Hill NT, Bubulya PA, Kadakia MP
Cell cycle (Georgetown, Tex.).
2013 May 1;
12(9).
doi: 10.4161/cc.24516
PMID: 23574721

Education

Wright State University in Dayton, Ohio
Ph.D., Biomedical Sciences, 2015
 
California State University, San Bernardino 
B.A., Chemistry, Biochemistry 
 
Midland College, Midland, Texas 
Associate’s Degree, General Sciences

Last Updated: June 2020