Summary

Lingling Miao was born and educated in China, receiving her Ph.D. degree from the Chinese Academy of Sciences (CAS) in 2013. After that, she worked as an assistant and then associate investigator in CAS studying miRNA-mediated gene regulation. She subsequently joined Dr. Isaac Brownell’s lab in 2016 as a visiting fellow to study Merkel cell development and the related skin cancer Merkel cell carcinoma.

Research Statement

Merkel cells are neuroendocrine cells in the epidermis with both neuronal and epithelial features. They are innervated by nerve endings and functions in light touch sensation. In mouse skin, Merkel cells cluster in a specialized structure called the touch dome. Merkel cells are derived from epithelial progenitors, however, the underlying molecular mechanisms of this process are largely unknown. Using sophisticated mouse genetics and single-cell transcriptome analysis Lingling Miao studies the roadmap of embryonic Merkel cell development, and the regulatory mechanisms through which epithelial progenitors give rise to neuroendocrine cells. Since embryonic development shares many similarities with tumorigenesis, she also investigates how the signaling pathways responsible for Merkel cell development function in Merkel cell carcinoma.

Scientific Publications

A Cascade of Wnt, Eda, and Shh Signaling Is Essential for Touch Dome Merkel Cell Development.

Xiao Y, Thoresen DT, Miao L, Williams JS, Wang C, Atit RP, Wong SY, Brownell I
PLoS genetics.
2016 Jul;
12(7).
doi: 10.1371/journal.pgen.1006150
PMID: 27414798

MiR-1254 suppresses HO-1 expression through seed region-dependent silencing and non-seed interaction with TFAP2A transcript to attenuate NSCLC growth.

Pu M, Li C, Qi X, Chen J, Wang Y, Gao L, Miao L, Ren J
PLoS genetics.
2017 Jul;
13(7).
doi: 10.1371/journal.pgen.1006896
PMID: 28749936

1,2:5,6-dianhydrogalactitol inhibits human glioma cell growth in vivo and in vitro by arresting the cell cycle at G2/M phase.

Peng C, Qi XM, Miao LL, Ren J
Acta pharmacologica Sinica.
2017 Apr;
38(4).
doi: 10.1038/aps.2016.154
PMID: 28216618

MicroRNA-1304 suppresses human non-small cell lung cancer cell growth in vitro by targeting heme oxygenase-1.

Li CG, Pu MF, Li CZ, Gao M, Liu MX, Yu CZ, Yan H, Peng C, Zhao Y, Li Y, Ma ZL, Qi XM, Wang YZ, Miao LL, Ren J
Acta pharmacologica Sinica.
2017 Jan;
38(1).
doi: 10.1038/aps.2016.92
PMID: 27641735

A dual inhibition: microRNA-552 suppresses both transcription and translation of cytochrome P450 2E1.

Miao L, Yao H, Li C, Pu M, Yao X, Yang H, Qi X, Ren J, Wang Y
Biochimica et biophysica acta.
2016 Apr;
1859(4).
doi: 10.1016/j.bbagrm.2016.02.016
PMID: 26926595

Role of multiple microRNAs in the sexually dimorphic expression of Cyp2b9 in mouse liver.

Xie X, Miao L, Yao J, Feng C, Li C, Gao M, Liu M, Gong L, Wang Y, Qi X, Ren J
Drug metabolism and disposition: the biological fate of chemicals.
2013 Oct;
41(10).
doi: 10.1124/dmd.113.052217
PMID: 23704697

Education

Shanghai Institute of Materia Medica & Institute of Neuroscience, CAS, Shanghai, China
Ph.D., Pharmacology, 2013

West China School of Pharmacy, Sichuan University, Chengdu, China
B.S., Pharmacy, 2007

Last Updated: June 2020