Summary

Keiko Sakamoto, M.D., Ph.D., is a board-certified Dermatologist (Japanese Association of Dermatology) and Stephen I. Katz Scholar in the Cutaneous Leukocyte Biology Section at the National Institute of Arthritis and Musculoskeletal and Skin Diseases. 

Dr. Sakamoto obtained her M.D. from Kagawa University Faculty of Medicine and Ph.D. from Hamamatsu University School of Medicine. She was a visiting fellow in the Nagao lab, Dermatology Branch, NIAMS, NIH from 2018 to 2021. After serving as faculty in the Department of Dermatology at Hamamatsu University School of Medicine, she returned to the NIH in 2023.

Research Statement

Dr. Sakamoto explores mechanisms that underlie cell-cell communication in the skin during homeostasis and disease. In 2021, she demonstrated that the Notch-ADAM10 signaling axis in the interferon-responsive hair follicles were required for regulating follicular microbiome, the disruption of which led to follicular dysbiosis and innate lymphoid cell-mediated destruction of the hair follicles (Sakamoto et al., Immunity 2021), modeling a form of scarring alopecia. Upon her return, she continues to study immune cell-tissue crosstalk in the context of basic skin immunology and human primary immunodeficiencies.

Scientific Publications

A case of nonpigmented fixed-drug eruption with eosinophilic intraepidermal vesicle formation.

Sakamoto K, Fujihiro M, Sakamoto A, Yamada C, Nagao K, Honda T
J Dermatol.
2023 Nov 10;
doi: 10.1111/1346-8138.17022
PMID: 37950416

Distinct use of super-enhancer elements controls cell type-specific CD25 transcription and function.

Spolski R, Li P, Chandra V, Shin B, Goel S, Sakamoto K, Liu C, Oh J, Ren M, Enomoto Y, West EE, Christensen SM, Wan ECK, Ge M, Lin JX, Yan B, Kazemian M, Yu ZX, Nagao K, Vijayanand P, Rothenberg EV, Leonard WJ
Sci Immunol.
2023 Nov 3;
8(89).
doi: 10.1126/sciimmunol.adi8217
PMID: 37922339

Macrophage-mediated extracellular matrix remodeling controls host Staphylococcus aureus susceptibility in the skin.

Voisin B, Nadella V, Doebel T, Goel S, Sakamoto K, Ayush O, Jo JH, Kelly MC, Kobayashi T, Jiang JX, Hu Y, Yan C, Nagao K
Immunity.
2023 Jul 11;
56(7).
doi: 10.1016/j.immuni.2023.06.006
PMID: 37402364

Mouse Models for Atopic Dermatitis.

Sakamoto K, Nagao K
Curr Protoc.
2023 Mar;
3(3).
doi: 10.1002/cpz1.709
PMID: 36971661

Identification of skin-infiltrating donor lymphocytes in a case of pre-engraftment syndrome.

Sakamoto K, Takatsuka I, Takemura T, Ono T, Nagakura Y, Pack SD, Nagao K, Honda T
J Dermatol.
2023 Sep;
50(9).
doi: 10.1111/1346-8138.16785
PMID: 36938663

T cell-rich perivascular inflammation in a case of cutaneous variant intravascular large B-cell lymphoma.

Sakamoto K, Baba T, Mori H, Misawa J, Honda T
J Dermatol.
2022 Dec;
49(12).
doi: 10.1111/1346-8138.16529
PMID: 35876148

The Double-Stranded RNA Analog, Poly(I:C), Triggers Distinct Transcriptomic Shifts in Keratinocyte Subsets.

Sakamoto K, Nagao K
J Invest Dermatol.
2022 Oct;
142(10).
doi: 10.1016/j.jid.2022.03.015
PMID: 35395221

A case of methotrexate-associated Epstein-Barr virus-positive mucocutaneous ulcer.

Sakamoto K, Baba T, Takatori H, Nagao K, Misawa J, Honda T
Skin Health Dis.
2022 Jun;
2(2).
doi: 10.1002/ski2.108
PMID: 35677919

Flow cytometry analysis of the subpopulations of mouse keratinocytes and skin immune cells.

Sakamoto K, Goel S, Funakoshi A, Honda T, Nagao K
STAR Protoc.
2022 Mar 18;
3(1).
doi: 10.1016/j.xpro.2021.101052
PMID: 34977690

Disruption of the endopeptidase ADAM10-Notch signaling axis leads to skin dysbiosis and innate lymphoid cell-mediated hair follicle destruction.

Sakamoto K, Jin SP, Goel S, Jo JH, Voisin B, Kim D, Nadella V, Liang H, Kobayashi T, Huang X, Deming C, Horiuchi K, Segre JA, Kong HH, Nagao K
Immunity.
2021 Oct 12;
54(10).
doi: 10.1016/j.immuni.2021.09.001
PMID: 34582748

Targeted therapy guided by single-cell transcriptomic analysis in drug-induced hypersensitivity syndrome: a case report.

Kim D, Kobayashi T, Voisin B, Jo JH, Sakamoto K, Jin SP, Kelly M, Pasieka HB, Naff JL, Meyerle JH, Ikpeama ID, Fahle GA, Davis FP, Rosenzweig SD, Alejo JC, Pittaluga S, Kong HH, Freeman AF, Nagao K
Nat Med.
2020 Feb;
26(2).
doi: 10.1038/s41591-019-0733-7
PMID: 31959990

Cell-autonomous FLT3L shedding via ADAM10 mediates conventional dendritic cell development in mouse spleen.

Fujita K, Chakarov S, Kobayashi T, Sakamoto K, Voisin B, Duan K, Nakagawa T, Horiuchi K, Amagai M, Ginhoux F, Nagao K
Proc Natl Acad Sci U S A.
2019 Jul 16;
116(29).
doi: 10.1073/pnas.1818907116
PMID: 31262819

Education

Kagawa University Faculty of Medicine (M.D.)

Hamamatsu University School of Medicine (Ph.D.)

Experience

Stephen I. Katz Scholar (Senior Research Fellow), Nagao Lab, Dermatology Branch, NIAMS, National Institute of Health (2023 – current)

Assistant Professor, Department of Dermatology, Hamamatsu University School of Medicine (2022) 

Attending Physician, Department of Dermatology, Hamamatsu Medical Center (2021) 

Visiting Fellow, Nagao Lab, Dermatology Branch, NIAMS, National Institute of Health (2019) 

Special Volunteer, Nagao Lab, Dermatology Branch, NIAMS, National Institute of Health (2018) 

Director, Department of Dermatology, Iwata City Hospital (2016) 

Attending Physician, Department of Dermatology, Iwata City Hospital (2008) 

Clinical Fellow, Hamamatsu University School of Medicine (2007) 

Resident, Hamamatsu Medical Center (2005) 

Resident, Department of Dermatology, Hamamatsu University School of Medicine (2004)

Last Updated: