Luciana Yamamoto de Almeida, DDS, Ph.D.

Summary

Luciana Yamamoto de Almeida completed her D.D.S. degree from the State University of Montes Claros, Brazil. Upon graduation, she earned her M.Sc. and Ph.D. at the State University of Campinas, Brazil, where she investigated the effects of fatty acid synthase inhibition on melanoma and oral squamous cell carcinoma. Dr. Yamamoto de Almeida earned a specialization in oral medicine and became a provisional professor at São Paulo State University, Brazil. There, she researched oral leukoplakia and managed the Oral Diagnosis clinic. She also pursued postdoctoral research training in hematology at the University of São Paulo, focusing on investigating combinational therapies using EGFR tyrosine kinase inhibitors, all-trans retinoic acid, and arsenic trioxide for acute promyelocytic leukemia. 

Dr. Yamamoto de Almeida joined NIDCR at NIH as a postdoctoral fellow working on osteoimmunology. She is continuing her postdoctoral training in the Vasculitis Translational Research Program at NIAMS under Dr. Peter Grayson.

Research Statement

Dr. Yamamoto de Almeida’s research focuses on understanding the pathogenesis of neoangiogenesis and collateral artery formation in patients with large vessel vasculitis.

Scientific Publications

M2 macrophages drive leukemic transformation by imposing resistance to phagocytosis and improving mitochondrial metabolism.

Weinhäuser I, Pereira-Martins DA, Almeida LY, Hilberink JR, Silveira DRA, Quek L, Ortiz C, Araujo CL, Bianco TM, Lucena-Araujo A, Mota JM, Hogeling SM, Sternadt D, Visser N, Diepstra A, Ammatuna E, Huls G, Rego EM, Schuringa JJ
Sci Adv.
2023 Apr 14;
9(15).
doi: 10.1126/sciadv.adf8522
PMID: 37058562

FASN inhibition sensitizes metastatic OSCC cells to cisplatin and paclitaxel by downregulating cyclin B1.

Almeida LY, Moreira FDS, Santos GASD, Cuadra Zelaya FJM, Ortiz CA, Agostini M, Mariano FS, Bastos DC, Daher URN, Kowalski LP, Coletta RD, Graner E
Oral Dis.
2023 Mar;
29(2).
doi: 10.1111/odi.14017
PMID: 34510641

High density of CD8 T cell and immune imbalance of T lymphocytes subsets are associated with proliferative verrucous leukoplakia.

Fernandes D, Barbeiro CO, Palaçon MP, Biancardi MR, Ferrisse TM, Silveira HA, Castilho RM, de Almeida LY, Leon JE, Bufalino A
Immunology.
2023 Jan;
168(1).
doi: 10.1111/imm.13565
PMID: 36056642

Mast cell-T cell axis alters development of colitis-dependent and colitis-independent colorectal tumours: potential for therapeutically targeting via mast cell inhibition.

Sakita JY, Elias-Oliveira J, Carlos D, de Souza Santos E, Almeida LY, Malta TM, Brunaldi MO, Albuquerque S, Araújo Silva CL, Andrade MV, Bonato VLD, Garcia SB, Cunha FQ, Cebinelli GCM, Martins RB, Matthews J, Colli L, Martin FL, Uyemura SA, Kannen V
J Immunother Cancer.
2022 Oct;
10(10).
doi: 10.1136/jitc-2022-004653
PMID: 36220303

Focal lymphocytic sialadenitis and ectopic germinal centers in oral reactive lesions and primary Sjögren's syndrome: a comparative study.

Silva EV, Almeida LY, Bortoletto KC, Quero IB, Jacomini FC, de Andrade BAB, Silveira HA, Duarte A, Petean FC, Rocha EM, Ribeiro-Silva A, Carlos R, León JE
Rheumatol Int.
2022 Aug;
42(8).
doi: 10.1007/s00296-021-04949-6
PMID: 34283264

The Combination of Gefitinib With ATRA and ATO Induces Myeloid Differentiation in Acute Promyelocytic Leukemia Resistant Cells.

de Almeida LY, Pereira-Martins DA, Weinhäuser I, Ortiz C, Cândido LA, Lange AP, De Abreu NF, Mendonza SES, de Deus Wagatsuma VM, Do Nascimento MC, Paiva HH, Alves-Paiva RM, Bonaldo CCOM, Nascimento DC, Alves-Filho JC, Scheucher PS, Lima ASG, Schuringa JJ, Ammantuna E, Ottone T, Noguera NI, Araujo CL, Rego EM
Front Oncol.
2021;
11().
doi: 10.3389/fonc.2021.686445
PMID: 34650910

Education

Federal Dental Council, Brazil 
Specialist in Oral Medicine (2017) 

State University of Campinas (UNICAMP), Brazil 
Ph.D. (2012 – 2015) 

State University of Campinas (UNICAMP), Brazil 
M.Sc. (2010 – 2012) 

State University of Montes Claros (UNIMONTES), Brazil 
Dentistry Graduate Education (2005 – 2009)

Experience

Postdoctoral Fellowship 
National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS/NIH) (2024-present) 

Postdoctoral Fellowship 
National Institute of Dental and Craniofacial Research (NIDCR/NIH) (2020-2024)

Provisional Professor of Oral Medicine 
São Paulo State University (UNESP), Brazil (2019) 

Postdoctoral Fellowship 
University of São Paulo (USP), Brazil (2016-2019)

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