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Data Analysis: Deregulated immune cell recruitment orchestrated by FOXM1 impairs human diabetic wound healing.

https://www.niams.nih.gov/labs/morasso-lab/data/FOXM1

This dataset includes 3 conditions: unwounded diabetic skin, diabetic non-healing wounds and diabetic healing wounds. For this analysis, we will compare non-healing vs healing diabetic wounds.

Higher Income and Longer Working Years are Linked to Better Mobility

https://www.niams.nih.gov/newsroom/press-releases/higher-income-and-longer-working-years-are-linked-better-mobility

A new study on the relationship between mobility and income has shown that better mobility was strongly associated with higher income and longer working years in adults.

NIH-FNIH Host Workshop on the Future of Regenerative Medicine and Cell-based Therapies

https://www.niams.nih.gov/about/meetings-events/roundtables/nih-fnih-host-workshop-future-regenerative-medicine-and-cell

The NIH and FNIH will be hosting a two-day workshop on the future of regenerative medicine and cell-based therapies on November 6 and 7, 2023.

NINDS Small Business Funding Leads to New Therapy for Duchenne Muscular Dystrophy

https://www.niams.nih.gov/ninds-small-business-funding-leads-new-therapy-duchenne-muscular-dystrophy

Duchenne muscular dystrophy (DMD) is a rare form of muscular dystrophy primarily affecting young boys. ReveraGen BioPharma, a company supported by a small business grant from the National Institute of Neurological Disorders and Stroke (NINDS), has developed a new drug for DMD, a genetic muscle-wasting disease.

Data Analysis: Transcriptional signature primes human oral mucosa for rapid wound healing

https://www.niams.nih.gov/labs/morasso-lab/data/transcriptional-signature

This study examines gene expression in human oral and skin at baseline (unwounded; day 1) and at days 3 and 6 of healing. Given that there are 6 groups, there are a number of interesting comparisons that are possible. As an example, we provide detailed instructions to determine differences between unwounded oral vs. skin (oral day 1 vs. skin day 1).

May 1, 2023 CLINICAL

Understanding How Skin Cancer Presentation and Survival Differs by Racial and Ethnic Groups

Isaac Brownell, M.D., Ph.D.

Cutaneous Development and Carcinogenesis Section

NIAMS IRP

Disparities in skin cancer presentation between races and ethnicities.

Cancer Biology Computational Biology Skin Biology

September 16, 2022 TRANSLATIONAL

Manual Counting Versus Artificial Intelligence in Assessing Monkeypox Lesions Using Patient Photographs

Dermatology Consultation Service

NIAMS IRP

An artificial intelligence (AI) algorithm can count mpox skin lesions in patient photographs with close correlation to manual counts.

Clinical Research Immunology Skin Biology

September 23, 2023 TRANSLATIONAL

Neutrophil Extracellular Traps (NETs) Trigger Pathogenic Inflammation and Bone Loss in Periodontitis

Mariana J. Kaplan, M.D.

Systemic Autoimmunity Branch

NIAMS IRP

Neutrophil Extracellular Traps (NETs) cause bone destruction in periodontitis lesions by triggering the IL-17/Th17 response.

Autoimmunity Cell Biology Clinical Research Immunology Molecular Biology and Biochemistry Systems Biology

May 2, 2023 CLINICAL

The Direct Binding of Anti-Mi2 Autoantibodies to Their Antigen Is Key to the Pathogenesis of Anti-Mi2 Dermatomyositis

Andrew Mammen, M.D., Ph.D.

Muscle Disease Section

NIAMS IRP

Dermatomyositis (DM) Patients with anti-Mi2 autoantibodies against a transcriptional repressor protein (CHD4/NuRD complex) showed severe muscle disease than other DM patients.

Clinical Research Immunology Muscle Biology

NIH Awards $9.7 Million to Advance the Use of All of Us Research Program Dataset

https://www.niams.nih.gov/nih-awards-97-million-advance-use-all-us-research-program-dataset

The National Institutes of Health’s All of Us Research Program and 10 partner Institutes, Centers, and Offices have funded 26 research projects to support novel analyses and tool development using All of Us’ data. The two-year awards advance impactful research in high-priority mission areas of the NIH.

Engagement with Patient Advocacy and Community Groups is Core to NIAMS’ Mission

https://www.niams.nih.gov/about/about-the-director/letter/engagement-patient-advocacy-and-community-groups-core-niams-mission

Since joining NIAMS in 2021, I have been struck by how much our mission is driven by meaningful interactions with patient advocacy and other community groups interested in research related to bones, joints, muscles, and skin.

AAAAI Annual Meeting

https://www.niams.nih.gov/newsroom/meetings-events/aaaai-annual-meeting

AAAAI Annual Meeting

Dandre Thornhill, Ph.D.

https://www.niams.nih.gov/about/directory/dandre-thornhill-phd

Dandre Thornhill is the Chief of the NIAMS Clinical Research Operations and Management Branch (CROMB)

NIAMS’ Mariana Kaplan Named NIH Distinguished Investigator

https://www.niams.nih.gov/newsroom/announcements/niams-mariana-kaplan-named-nih-distinguished-investigator

Mariana Kaplan, M.D., a longstanding NIAMS researcher and leader, has been promoted to the title of NIH Distinguished Investigator.

Immunology 2024

https://www.niams.nih.gov/newsroom/meetings-events/immunology-2024

Immunology 2024

Study Identifies Subtypes of Inflammation in People with Rheumatoid Arthritis

https://www.niams.nih.gov/newsroom/spotlight-on-research/study-identifies-subtypes-inflammation-people-rheumatoid-arthritis

Rheumatoid arthritis (RA) is an autoimmune disease that causes joint inflammation, pain, and stiffness. There are several treatment options to control inflammation, but response to therapy varies and some people with RA never reach remission, suggesting there may be different drivers of inflammation.

NIH Websites Are Changing

Data Analysis: Deregulated immune cell recruitment orchestrated by FOXM1 impairs human diabetic wound healing.

Higher Income and Longer Working Years are Linked to Better Mobility

NIH-FNIH Host Workshop on the Future of Regenerative Medicine and Cell-based Therapies

NINDS Small Business Funding Leads to New Therapy for Duchenne Muscular Dystrophy

Data Analysis: Transcriptional signature primes human oral mucosa for rapid wound healing

Understanding How Skin Cancer Presentation and Survival Differs by Racial and Ethnic Groups

Manual Counting Versus Artificial Intelligence in Assessing Monkeypox Lesions Using Patient Photographs

Neutrophil Extracellular Traps (NETs) Trigger Pathogenic Inflammation and Bone Loss in Periodontitis

The Direct Binding of Anti-Mi2 Autoantibodies to Their Antigen Is Key to the Pathogenesis of Anti-Mi2 Dermatomyositis

NIH Awards $9.7 Million to Advance the Use of All of Us Research Program Dataset

Engagement with Patient Advocacy and Community Groups is Core to NIAMS’ Mission

AAAAI Annual Meeting

Dandre Thornhill, Ph.D.

NIAMS’ Mariana Kaplan Named NIH Distinguished Investigator

Immunology 2024

Study Identifies Subtypes of Inflammation in People with Rheumatoid Arthritis

Linda Yang, Ph.D.

Carpal Tunnel Syndrome

Síndrome del túnel carpiano

NIAMS Forum for Clinical Mentored K Awardees - December 2022

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