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CLINICAL

Genetic variants of hemophagocytic lymphohistiocytosis genes are enriched in children with systemic juvenile idiopathic arthritis

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NIAMS IRP
Familial hemophagocytic lymphohistiocytosis (HLH) is a life-threatening cytokine storm syndrome caused by recessive, loss of function variants of genes in the pathway that controls the processing of cytolytic granule processing pathway genes. Heterozygous variants in these genes contribute to a secondary form of HLH (macrophage activation syndrome, MAS) that frequently develops in children with systemic juvenile idiopathic arthritis (sJIA). To evaluate the relationship between HLH gene variation and sJIA without MAS, HLH genes were sequenced and compared between 524 patients with sJIA and 2,924 control patients.
Autoimmunity Genetics and Genomics

The American Society for Bone and Mineral Research (ASBMR), 2024 Annual Meeting

https://www.niams.nih.gov/newsroom/meetings-events/american-society-bone-and-mineral-research-asbmr-2024-annual-meeting

The ASBMR Annual Meeting is the world’s largest and most diverse meeting in the bone, mineral and musculoskeletal research field, attracting more than 2,500 attendees from more than 50 countries, including clinicians and researchers, representing all career levels and specializing in a variety of disciplines.

DC Lupus Consortium - 30th Anniversary of Lupus Clinical Research

https://www.niams.nih.gov/newsroom/meetings-events/dc-lupus-consortium-30th-anniversary-lupus-clinical-research

This event will highlight the outstanding progress in lupus clinical research made by NIH over the last 30 years, featuring testimonials from research participants, updates on current lupus research activities at NIAMS, and discussions on the future direction of research at the NIH. The event seeks to build on the success of DC Lupus Consortium- a platform to collaborate between NIH scientists, physicians outside the NIH and patient advocacy groups interested in Lupus Clinical Research.

Benign Nail Condition Linked to Rare Syndrome that Greatly Increases Cancer Risk

https://www.niams.nih.gov/newsroom/press-releases/benign-nail-condition-linked-rare-syndrome-greatly-increases-cancer-risk

Scientists at the National Institutes of Health (NIH) have discovered that the presence of a benign nail abnormality may lead to the diagnosis of a rare inherited disorder that increases the risk of developing cancerous tumors of the skin, eyes, kidneys and the tissue that lines the chest and abdomen (e.g., the mesothelium).

Typically materials from NIAMS that are more than 5 years old will be archived.

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