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R03 Information for NIAMS K Award Recipients

https://www.niams.nih.gov/grants-funding/research-training-and-career-development-programs/r03-information-niams-k-award

NIAMS Small Grant Program for New Investigators (R03) Read the NOFO: Limited Competition: Small Grant Program for NIAMS K01, K08, K23, and K25 Recipients (R03) (Clinical Trials Not Allowed) Program Purpose: The National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) is seeking small grant (R03) applications to stimulate

Researchers Identify a Disease-Causing Immune Cell Imbalance in Lupus

https://www.niams.nih.gov/newsroom/spotlight-on-research/researchers-identify-disease-causing-immune-cell-imbalance-lupus

Overview A team of NIAMS-funded researchers discovered an imbalance of T cell subtypes in patients with lupus that contributes to ongoing production of disease-causing autoantibodies. Compared to healthy individuals, patients with lupus have more T cells with specialized B cell helper functions and fewer T cells that are important for wound healing and maintaining the epithelial barrier, which acts to protect the body from pathogens and other invaders. The team identified two molecules that control this imbalance, which could be the targets of lupus treatments in the future. The study was recently published in the journal Nature. Background Systemic lupus
CLINICAL

Skin Manifestations of VEXAS Syndrome and Associated Genotypes May Aid in Quicker Diagnosis

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NIAMS IRP
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NIAMS IRP
A team of researchers in the Dermatology Consultation Service analyzed tissue samples from 60 of 112 study participants who were referred to the NIH Clinical Center in Bethesda, MD, for suspected VEXAS syndrome. The most reported findings included inflammation of the small blood vessels of the skin, known as leukocystoclastic vasculitis, fever and a painful rash known as neutrophilic dermatosis, and inflammation of the skin around the blood vessels, known as perivascular dermatitis.
Clinical Research Genetics and Genomics Immunology Skin Biology

Array of Patient Recruitment Efforts Boost Back Pain Study Participation

https://www.niams.nih.gov/newsroom/spotlight-on-research/array-patient-recruitment-efforts-boost-back-pain-study

Back pain is one of the most common forms of chronic pain affecting adults. People with chronic back pain often take opioids for pain management, but opioids are highly addictive. To address this public health challenge, in 2019 NIH launched the Back Pain Consortium (BACPAC) Research Program, part of the NIH Helping to End Addiction Long-term® (HEAL) Initiative that launched in 2018, a patient-centered effort to address the need for non-addictive, effective and personalized therapies for chronic back pain. Scientists are conducting clinical trials with the hopes of finding new non-opioid treatments. Yet for clinical trials to be effective, the
BASIC

A computational method to improve analysis of single cell RNA-sequencing

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NIAMS IRP
In this report, researchers described a deep neural generative framework, the dynamic batching adversarial autoencoder (DB-AAE), which excels at denoising scRNA-seq datasets. DB-AAE directly captures optimal features from input data and enhances feature preservation, including cell type-specific gene expression patterns.
Computational Biology Genetics and Genomics
BASIC

HLA-B27 does not trigger gut inflammation through the unfolded protein response

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NIAMS IRP
Spondyloarthritis (SpA) is an inflammatory disease that affects the gastrointestinal tract, skeleton, and eyes. HLA-B27 is a major risk gene for SpA, but the underlying mechanisms are unclear. One hypothesis is that HLA-B27 promotes SpA through misfolding-induced endoplasmic reticulum (ER) stress that in turn upregulates IL-23 expression via the transcription factor CHOP. In this study, the researchers knocked out CHOP expression in an animal model of HLA-B27-associated SpA. Despite reduced IL-23 production, gut inflammation did not improve, indicating that the gut disease did not occur as a result of ER stress-induced IL-23 production.
Genetics and Genomics Immunology Molecular Biology and Biochemistry
CLINICAL

Genetic variants of hemophagocytic lymphohistiocytosis genes are enriched in children with systemic juvenile idiopathic arthritis

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NIAMS IRP
Familial hemophagocytic lymphohistiocytosis (HLH) is a life-threatening cytokine storm syndrome caused by recessive, loss of function variants of genes in the pathway that controls the processing of cytolytic granule processing pathway genes. Heterozygous variants in these genes contribute to a secondary form of HLH (macrophage activation syndrome, MAS) that frequently develops in children with systemic juvenile idiopathic arthritis (sJIA). To evaluate the relationship between HLH gene variation and sJIA without MAS, HLH genes were sequenced and compared between 524 patients with sJIA and 2,924 control patients.
Autoimmunity Genetics and Genomics

The American Society for Bone and Mineral Research (ASBMR), 2024 Annual Meeting

https://www.niams.nih.gov/newsroom/meetings-events/american-society-bone-and-mineral-research-asbmr-2024-annual-meeting

The ASBMR Annual Meeting is the world’s largest and most diverse meeting in the bone, mineral and musculoskeletal research field, attracting more than 2,500 attendees from more than 50 countries, including clinicians and researchers, representing all career levels and specializing in a variety of disciplines.

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