Summary

Dr. Deng received his Ph.D. in Human Molecular Genetics from the University of Texas M. D. Anderson Cancer Center and Graduate School of Biomedical Sciences. He also has an M.S. in Computer Science from Johns Hopkins University. His research career spans academia, industry and government with extensive experience in human genetics, genomics, and bioinformatics.

Research Statement

Mutation analysis and functional genomics through Next Generation Sequencing and computational tools development.

Scientific Publications

Somatic SMAD3-activating mutations cause melorheostosis by up-regulating the TGF-β/SMAD pathway.

Kang H, Jha S, Ivovic A, Fratzl-Zelman N, Deng Z, Mitra A, Cabral WA, Hanson EP, Lange E, Cowen EW, Katz J, Roschger P, Klaushofer K, Dale RK, Siegel RM, Bhattacharyya T, Marini JC
The Journal of experimental medicine.
2020 May 4;
217(5).
pii: e20191499. doi: 10.1084/jem.20191499
PMID: 32232430

Distinct interferon signatures and cytokine patterns define additional systemic autoinflammatory diseases.

de Jesus AA, Hou Y, Brooks S, Malle L, Biancotto A, Huang Y, Calvo KR, Marrero B, Moir S, Oler AJ, Deng Z, Montealegre Sanchez GA, Ahmed A, Allenspach E, Arabshahi B, Behrens E, Benseler S, Bezrodnik L, Bout-Tabaku S, Brescia AC, Brown D, Burnham JM, Caldirola MS, Carrasco R, Chan AY, Cimaz R, Dancey P, Dare J, DeGuzman M, Dimitriades V, Ferguson I, Ferguson P, Finn L, Gattorno M, Grom AA, Hanson EP, Hashkes PJ, Hedrich CM, Herzog R, Horneff G, Jerath R, Kessler E, Kim H, Kingsbury DJ, Laxer RM, Lee PY, Lee-Kirsch MA, Lewandowski L, Li S, Lilleby V, Mammadova V, Moorthy LN, Nasrullayeva G, O'Neil KM, Onel K, Ozen S, Pan N, Pillet P, Piotto DG, Punaro MG, Reiff A, Reinhardt A, Rider LG, Rivas-Chacon R, Ronis T, Rösen-Wolff A, Roth J, Ruth NM, Rygg M, Schmeling H, Schulert G, Scott C, Seminario G, Shulman A, Sivaraman V, Son MB, Stepanovskiy Y, Stringer E, Taber S, Terreri MT, Tifft C, Torgerson T, Tosi L, Van Royen-Kerkhof A, Wampler Muskardin T, Canna SW, Goldbach-Mansky R
The Journal of clinical investigation.
2020 Apr 1;
130(4).
doi: 10.1172/JCI129301
PMID: 31874111

Somatic activating mutations in MAP2K1 cause melorheostosis.

Kang H, Jha S, Deng Z, Fratzl-Zelman N, Cabral WA, Ivovic A, Meylan F, Hanson EP, Lange E, Katz J, Roschger P, Klaushofer K, Cowen EW, Siegel RM, Marini JC, Bhattacharyya T
Nature communications.
2018 Apr 11;
9(1).
doi: 10.1038/s41467-018-03720-z
PMID: 29643386

Germline gain-of-function myeloid differentiation primary response gene-88 (MYD88) mutation in a child with severe arthritis.

Sikora KA, Bennett JR, Vyncke L, Deng Z, Tsai WL, Pauwels E, Layh-Schmitt G, Brundidge A, Navid F, Zaal KJM, Hanson E, Gadina M, Staudt LM, Griffin TA, Tavernier J, Peelman F, Colbert RA
The Journal of allergy and clinical immunology.
2018 May;
141(5).
doi: 10.1016/j.jaci.2018.01.027
PMID: 29427642

An activating NLRC4 inflammasome mutation causes autoinflammation with recurrent macrophage activation syndrome.

Canna SW, de Jesus AA, Gouni S, Brooks SR, Marrero B, Liu Y, DiMattia MA, Zaal KJ, Sanchez GA, Kim H, Chapelle D, Plass N, Huang Y, Villarino AV, Biancotto A, Fleisher TA, Duncan JA, O'Shea JJ, Benseler S, Grom A, Deng Z, Laxer RM, Goldbach-Mansky R
Nature genetics.
2014 Oct;
46(10).
doi: 10.1038/ng.3089
PMID: 25217959

Activated STING in a vascular and pulmonary syndrome.

Liu Y, Jesus AA, Marrero B, Yang D, Ramsey SE, Sanchez GAM, Tenbrock K, Wittkowski H, Jones OY, Kuehn HS, Lee CR, DiMattia MA, Cowen EW, Gonzalez B, Palmer I, DiGiovanna JJ, Biancotto A, Kim H, Tsai WL, Trier AM, Huang Y, Stone DL, Hill S, Kim HJ, St Hilaire C, Gurprasad S, Plass N, Chapelle D, Horkayne-Szakaly I, Foell D, Barysenka A, Candotti F, Holland SM, Hughes JD, Mehmet H, Issekutz AC, Raffeld M, McElwee J, Fontana JR, Minniti CP, Moir S, Kastner DL, Gadina M, Steven AC, Wingfield PT, Brooks SR, Rosenzweig SD, Fleisher TA, Deng Z, Boehm M, Paller AS, Goldbach-Mansky R
The New England journal of medicine.
2014 Aug 7;
371(6).
doi: 10.1056/NEJMoa1312625
PMID: 25029335

Education

  • Ph.D. in Human Molecular Genetics, University of Texas M. D. Anderson Cancer Center and Graduate School of Biomedical Sciences.
  • M.S. in Computer Science, Johns Hopkins University
  • B.S. in Biochemistry, Sichuan University

Experience

  • Staff Scientist, BMDS, OST, NIAMS, NIH
  • Senior Bioinformatics Application Scientist, Complete Genomics
  • Senior Scientist, CGF, NCI, NIH
  • Computational Biologist, ARS, USDA
  • Bioinformatics Scientist, Northrop Grumman
  • Staff Scientist, Celera Genomics
  • Postdoctoral Fellow, NHGRI/NIAMS, NIH
Last Updated: July 2020