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    Overview

    Research Areas (IRP Lab Groups)

    Clinical Research,
    Immunology,
    Skin Biology

    Through the Dermatology Consultation Service at the NIH Clinical Center, patients with a variety of rare diseases with cutaneous manifestations are evaluated. In addition, patients who experience adverse reactions to experimental therapeutic agents or manifest unrelated skin conditions while at the NIH are assessed and treated. We provide training to Dermatology Branch clinical fellows, fellows from other NIH Institutes, and visiting dermatology residents from around the country. 'Grand Rounds at the NIH', an ongoing feature published in the Journal of the American Academy of Dermatology, selects and highlights interesting cases that we have evaluated.

    Dr. Cowen's primary research interest involves chronic graft-versus-host disease (cGVHD) and autoinflammatory diseases. He is Co-Study Chair of a multi-disciplinary NIH initiative aimed at the study and treatment of cGVHD (04-C-0281) and Principal Investigator of a therapeutic study of topical ruxolitinib for cutaneous cGVHD (18-AR-0035).

    Ongoing Clinical Trials

    RECRUITING

    Topical Ruxolitinib for Cutaneous Chronic Graft Versus Host Disease (cGVHD)

    ClinicalTrials.gov Identifier: NCT03395340

    About half the people who have a hematopoietic stem cell transplant using donor cells get cGVHD. This is chronic graft versus host disease. Immune cells from the donor may see the body tissues in the person as foreign and attack, causing damage. The skin is the most commonly affected organ. Most cGVHD therapies have serious side effects. The cream ruxolitinib inhibits proteins that may play a role in cGVHD. The objective of this study is to test the safety and effectiveness of topical ruxolitinib 1.5 percent cream in people with cGVHD of the skin.

    RECRUITING

    Evaluation and Treatment of Subjects with Dermatologic Diseases

    ClinicalTrials.gov Identifier: NCT00001506

    This is a training, natural history of disease, and screening protocol for the evaluation, treatment and follow-up of patients with dermatologic diseases and systemic diseases with cutaneous manifestations.

    Related NIAMS Labs

    Core Research Facilities

    Labs at the NIAMS are supported by the following state-of-the-art facilities and services:

    Staff

    Former Lab Members

    Clinical Fellows

    • Rachel Rosenstein, M.D., Ph.D.
    • Dominique Pichard, M.D., M.H.Sc.

    Medical Students

    • Suzanne Ward, M.D. (Dermatology)
    • Rena Zuo, M.D. (Dermatology)
    • Kathryn Martires, M.D. (Dermatology)
    • Asha Patel, M.D. (Dermatology)
     

    Scientific Publications

    Selected Recent Publications

    Host-Pathogen Interactions in Human Polyomavirus 7‒Associated Pruritic Skin Eruption.

    Rosenstein RK, Pastrana DV, Starrett GJ, Sapio MR, Hill NT, Jo JH, Lee CR, Iadarola MJ, Buck CB, Kong HH, Brownell I, Cowen EW
    J Invest Dermatol.
    2021 May;
    141(5).
    doi: 10.1016/j.jid.2020.09.014
    PMID: 33075349

    Quality of Life in Patients With Skin of Color and Chronic Graft-vs-Host Disease.

    Smith ZI, Rosenstein RK, Banerjee S, Pichard DC, Pavletic SZ, Cowen EW
    JAMA Dermatol.
    2020 May 1;
    156(5).
    doi: 10.1001/jamadermatol.2019.4857
    PMID: 32049308

    Rehabilitation Interventions in the Multidisciplinary Management of Patients With Sclerotic Graft-Versus-Host Disease of the Skin and Fascia.

    Molés-Poveda P, Comis LE, Joe GO, Mitchell SA, Pichard DC, Rosenstein RK, Solomon B, Pavletic SZ, Cowen EW
    Arch Phys Med Rehabil.
    2021 Apr;
    102(4).
    doi: 10.1016/j.apmr.2020.10.141
    PMID: 33347890

    Distribution and Functional Consequences of Somatic MAP2K1 Variants in Affected Skin Associated with Bone Lesions in Melorheostosis.

    Jha S, Ivovic A, Kang H, Meylan F, Hanson EP, Rimland C, Lange E, Katz J, McBride A, Warner AC, Edmondson EF, Cowen EW, Marini JC, Siegel RM, Bhattacharyya T
    J Invest Dermatol.
    2021 Mar;
    141(3).
    doi: 10.1016/j.jid.2020.06.036
    PMID: 32791068

    Calcinosis Cutis in the Setting of Chronic Skin Graft-Versus-Host Disease.

    Saardi KM, Rosenstein RK, Anadkat MJ, Micheletti RG, Schiffenbauer AI, Pavletic SZ, Cowen EW
    JAMA Dermatol.
    2020 Jul 1;
    156(7).
    doi: 10.1001/jamadermatol.2020.1157
    PMID: 32432645

    Voriconazole and the Risk of Keratinocyte Carcinomas Among Lung Transplant Recipients in the United States.

    D'Arcy ME, Pfeiffer RM, Rivera DR, Hess GP, Cahoon EK, Arron ST, Brownell I, Cowen EW, Israni AK, Triplette MA, Yanik EL, Engels EA
    JAMA Dermatol.
    2020 Jul 1;
    156(7).
    doi: 10.1001/jamadermatol.2020.1141
    PMID: 32401271

    Key Publications

    Janus kinase (JAK) inhibition with baricitinib in refractory juvenile dermatomyositis.

    Kim H, Dill S, O'Brien M, Vian L, Li X, Manukyan M, Jain M, Adeojo LW, George J, Perez M, Grom AA, Sutter M, Feldman BM, Yao L, Millwood M, Brundidge A, Pichard DC, Cowen EW, Shi Y, Lu S, Tsai WL, Gadina M, Rider LG, Colbert RA
    Ann Rheum Dis.
    2020 Aug 25;
    pii: annrheumdis-2020-218690. doi: 10.1136/annrheumdis-2020-218690
    PMID: 32843325

    Graft-versus-host disease: part I. Pathogenesis and clinical manifestations of graft-versus-host disease.

    Hymes SR, Alousi AM, Cowen EW
    J Am Acad Dermatol.
    2012 Apr;
    66(4).
    doi: 10.1016/j.jaad.2011.11.960
    PMID: 22421123

    Sclerotic-type chronic GVHD of the skin: clinical risk factors, laboratory markers, and burden of disease.

    Martires KJ, Baird K, Steinberg SM, Grkovic L, Joe GO, Williams KM, Mitchell SA, Datiles M, Hakim FT, Pavletic SZ, Cowen EW
    Blood.
    2011 Oct 13;
    118(15).
    doi: 10.1182/blood-2011-04-350249
    PMID: 21791415

    Chronic phototoxicity and aggressive squamous cell carcinoma of the skin in children and adults during treatment with voriconazole.

    Cowen EW, Nguyen JC, Miller DD, McShane D, Arron ST, Prose NS, Turner ML, Fox LP
    J Am Acad Dermatol.
    2010 Jan;
    62(1).
    doi: 10.1016/j.jaad.2009.09.033
    PMID: 19896749

    An autoinflammatory disease with deficiency of the interleukin-1-receptor antagonist.

    Aksentijevich I, Masters SL, Ferguson PJ, Dancey P, Frenkel J, van Royen-Kerkhoff A, Laxer R, Tedgård U, Cowen EW, Pham TH, Booty M, Estes JD, Sandler NG, Plass N, Stone DL, Turner ML, Hill S, Butman JA, Schneider R, Babyn P, El-Shanti HI, Pope E, Barron K, Bing X, Laurence A, Lee CC, Chapelle D, Clarke GI, Ohson K, Nicholson M, Gadina M, Yang B, Korman BD, Gregersen PK, van Hagen PM, Hak AE, Huizing M, Rahman P, Douek DC, Remmers EF, Kastner DL, Goldbach-Mansky R
    N Engl J Med.
    2009 Jun 4;
    360(23).
    doi: 10.1056/NEJMoa0807865
    PMID: 19494218

    Measuring therapeutic response in chronic graft-versus-host disease: National Institutes of Health Consensus Development Project on Criteria for Clinical Trials in Chronic Graft-versus-Host Disease: IV. Response Criteria Working Group report.

    Pavletic SZ, Martin P, Lee SJ, Mitchell S, Jacobsohn D, Cowen EW, Turner ML, Akpek G, Gilman A, McDonald G, Schubert M, Berger A, Bross P, Chien JW, Couriel D, Dunn JP, Fall-Dickson J, Farrell A, Flowers ME, Greinix H, Hirschfeld S, Gerber L, Kim S, Knobler R, Lachenbruch PA, Miller FW, Mittleman B, Papadopoulos E, Parsons SK, Przepiorka D, Robinson M, Ward M, Reeve B, Rider LG, Shulman H, Schultz KR, Weisdorf D, Vogelsang GB, Response Criteria Working Group.
    Biol Blood Marrow Transplant.
    2006 Mar;
    12(3).
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    Last Updated: March 2022 Back to Top