Through the Dermatology Consultation Service at the NIH Clinical Center, patients with a variety of rare diseases with cutaneous manifestations are evaluated. In addition, patients who experience adverse reactions to experimental therapeutic agents or manifest unrelated skin conditions while at the NIH are assessed and treated. We provide training to Dermatology Branch clinical fellows, fellows from other NIH Institutes, and visiting dermatology residents from around the country. 'Grand Rounds at the NIH', an ongoing feature published in the Journal of the American Academy of Dermatology, selects and highlights interesting cases that we have evaluated.
Dr. Cowen's primary research interest involves chronic graft-versus-host disease (cGVHD) and autoinflammatory diseases. He is Co-Study Chair of a multi-disciplinary NIH initiative aimed at the study and treatment of cGVHD (04-C-0281) and Principal Investigator of a therapeutic study of topical ruxolitinib for cutaneous cGVHD (18-AR-0035).
Ongoing Clinical Trials
ClinicalTrials.gov Identifier: NCT03395340
About half the people who have a hematopoietic stem cell transplant using donor cells get cGVHD. This is chronic graft versus host disease. Immune cells from the donor may see the body tissues in the person as foreign and attack, causing damage. The skin is the most commonly affected organ. Most cGVHD therapies have serious side effects. The cream ruxolitinib inhibits proteins that may play a role in cGVHD. The objective of this study is to test the safety and effectiveness of topical ruxolitinib 1.5 percent cream in people with cGVHD of the skin.
ClinicalTrials.gov Identifier: NCT00001506
This is a training, natural history of disease, and screening protocol for the evaluation, treatment and follow-up of patients with dermatologic diseases and systemic diseases with cutaneous manifestations.
Former Lab Members
- Rachel Rosenstein, M.D., Ph.D.
- Dominique Pichard, M.D., M.H.Sc.
- Suzanne Ward, M.D. (Dermatology)
- Rena Zuo, M.D. (Dermatology)
- Kathryn Martires, M.D. (Dermatology)
- Asha Patel, M.D. (Dermatology)