Principal Investigator

Edward W. Cowen, M.D., M.H.Sc.

Edward Cowen, M.D., leads the NIH Dermatology Consultation Service and oversees continuing medication, fellowship and resident education programs. He is an internationally recognized expert in cutaneous graft-versus-host disease (GVHD).

Through the Dermatology Consultation Service at the NIH Clinical Center, patients with a variety of rare diseases with cutaneous manifestations are evaluated. In addition, patients who experience adverse reactions to experimental therapeutic agents or manifest unrelated skin conditions while at the NIH are evaluated and treated. Dermatology Branch clinical fellows, fellows from other NIH Institutes, and visiting dermatology residents from around the country receive training on the Dermatology consult service. 'Grand Rounds at the NIH', an ongoing feature published in the Journal of the American Academy of Dermatology, highlights interesting cases evaluated by the Dermatology consultation service. Dr. Cowen's primary research interest involves chronic graft-versus-host disease (cGVHD) and autoinflammatory diseases. He is Co-Study Chair of a multi-disciplinary NIH initiative aimed at the study and treatment of cGVHD (NCI #04-C-0281) and Principal Investigator of a therapeutic study of anakinra for pustular skin disease(NCI #13-C-0071).

Ongoing Clinical Trials

Scientific Publications



Graft-versus-host disease: part I. Pathogenesis and clinical manifestations of graft-versus-host disease.

Hymes SR, Alousi AM, Cowen EW
Journal of the American Academy of Dermatology.
2012 Apr;
doi: 10.1016/j.jaad.2011.11.960
PMID: 22421123

Sclerotic-type chronic GVHD of the skin: clinical risk factors, laboratory markers, and burden of disease.

Martires KJ, Baird K, Steinberg SM, Grkovic L, Joe GO, Williams KM, Mitchell SA, Datiles M, Hakim FT, Pavletic SZ, Cowen EW
2011 Oct 13;
doi: 10.1182/blood-2011-04-350249
PMID: 21791415

Chronic phototoxicity and aggressive squamous cell carcinoma of the skin in children and adults during treatment with voriconazole.

Cowen EW, Nguyen JC, Miller DD, McShane D, Arron ST, Prose NS, Turner ML, Fox LP
Journal of the American Academy of Dermatology.
2010 Jan;
doi: 10.1016/j.jaad.2009.09.033
PMID: 19896749

An autoinflammatory disease with deficiency of the interleukin-1-receptor antagonist.

Aksentijevich I, Masters SL, Ferguson PJ, Dancey P, Frenkel J, van Royen-Kerkhoff A, Laxer R, Tedgård U, Cowen EW, Pham TH, Booty M, Estes JD, Sandler NG, Plass N, Stone DL, Turner ML, Hill S, Butman JA, Schneider R, Babyn P, El-Shanti HI, Pope E, Barron K, Bing X, Laurence A, Lee CC, Chapelle D, Clarke GI, Ohson K, Nicholson M, Gadina M, Yang B, Korman BD, Gregersen PK, van Hagen PM, Hak AE, Huizing M, Rahman P, Douek DC, Remmers EF, Kastner DL, Goldbach-Mansky R
The New England journal of medicine.
2009 Jun 4;
doi: 10.1056/NEJMoa0807865
PMID: 19494218

Measuring therapeutic response in chronic graft-versus-host disease: National Institutes of Health Consensus Development Project on Criteria for Clinical Trials in Chronic Graft-versus-Host Disease: IV. Response Criteria Working Group report.

Pavletic SZ, Martin P, Lee SJ, Mitchell S, Jacobsohn D, Cowen EW, Turner ML, Akpek G, Gilman A, McDonald G, Schubert M, Berger A, Bross P, Chien JW, Couriel D, Dunn JP, Fall-Dickson J, Farrell A, Flowers ME, Greinix H, Hirschfeld S, Gerber L, Kim S, Knobler R, Lachenbruch PA, Miller FW, Mittleman B, Papadopoulos E, Parsons SK, Przepiorka D, Robinson M, Ward M, Reeve B, Rider LG, Shulman H, Schultz KR, Weisdorf D, Vogelsang GB, Response Criteria Working Group.
Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation.
2006 Mar;
Last Updated: May 2020