Overview

Health outcomes represent all physical and social consequences of disease. These include symptoms, functioning, costs, complications of treatment, and mortality.

The overall goals of our research effort are to:

  1. Understand the factors that influence health outcomes of patients with systemic lupus erythematosus, ankylosing spondylitis, and rheumatoid arthritis.
  2. Develop new tools and techniques to measure outcomes in these diseases.
  3. Assess rheumatic disease in an underserved minority community.
  4. Compare outcomes among patients having orthopedic surgery.

Patient-related factors, such as demographic characteristics, genetic background, and treatment, influence health outcomes. Certain provider-related factors, including access to care, also influence health outcomes. We are studying genetic, clinical, and treatment influences on functional and structural outcomes in ankylosing spondylitis, and provider influences on outcomes in patients with lupus nephritis and hospitalized patients with systemic lupus erythematosus. Among measures of health outcomes, we are testing criteria for clinically important changes in symptoms in patients with rheumatoid arthritis, and are developing methods to quantify the progression of spinal fusion in patients with ankylosing spondylitis. We are examining associations between chronic bisphosphonate use and bone structure and risk of hip fracture.

Scientific Publications

 

 

American College of Rheumatology/Spondylitis Association of America/Spondyloarthritis Research and Treatment Network 2015 Recommendations for the Treatment of Ankylosing Spondylitis and Nonradiographic Axial Spondyloarthritis.

Ward MM, Deodhar A, Akl EA, Lui A, Ermann J, Gensler LS, Smith JA, Borenstein D, Hiratzka J, Weiss PF, Inman RD, Majithia V, Haroon N, Maksymowych WP, Joyce J, Clark BM, Colbert RA, Figgie MP, Hallegua DS, Prete PE, Rosenbaum JT, Stebulis JA, van den Bosch F, Yu DT, Miller AS, Reveille JD, Caplan L
Arthritis & rheumatology (Hoboken, N.J.).
2016 Feb;
68(2).
doi: 10.1002/art.39298
PMID: 26401991

Comparative efficacy of non-steroidal anti-inflammatory drugs in ankylosing spondylitis: a Bayesian network meta-analysis of clinical trials.

Wang R, Dasgupta A, Ward MM
Annals of the rheumatic diseases.
2016 Jun;
75(6).
doi: 10.1136/annrheumdis-2015-207677
PMID: 26248636

Progression of Nonradiographic Axial Spondyloarthritis to Ankylosing Spondylitis: A Population-Based Cohort Study.

Wang R, Gabriel SE, Ward MM
Arthritis & rheumatology (Hoboken, N.J.).
2016 Jun;
68(6).
doi: 10.1002/art.39542
PMID: 26663907

Risk of End-Stage Renal Disease in Patients With Lupus Nephritis, 1971-2015: A Systematic Review and Bayesian Meta-Analysis.

Tektonidou MG, Dasgupta A, Ward MM
Arthritis & rheumatology (Hoboken, N.J.).
2016 Jun;
68(6).
doi: 10.1002/art.39594
PMID: 26815601

Spatial distribution of syndesmophytes along the vertebral rim in ankylosing spondylitis: preferential involvement of the posterolateral rim.

Tan S, Dasgupta A, Yao J, Flynn JA, Yao L, Ward MM
Annals of the rheumatic diseases.
2016 Nov;
75(11).
doi: 10.1136/annrheumdis-2015-208802
PMID: 26797721

Standards of Comparison and Discordance in Rheumatoid Arthritis Global Assessments Between Patients and Clinicians.

Ward MM, Guthrie LC, Alba MI
Arthritis care & research.
2017 Aug;
69(8).
doi: 10.1002/acr.23103
PMID: 27696779

Survival in adults and children with systemic lupus erythematosus: a systematic review and Bayesian meta-analysis of studies from 1950 to 2016.

Tektonidou MG, Lewandowski LB, Hu J, Dasgupta A, Ward MM
Annals of the rheumatic diseases.
2017 Dec;
76(12).
doi: 10.1136/annrheumdis-2017-211663
PMID: 28794077

Comparative Efficacy of Tumor Necrosis Factor-α Inhibitors in Ankylosing Spondylitis: A Systematic Review and Bayesian Network Metaanalysis.

Wang R, Dasgupta A, Ward MM
The Journal of rheumatology.
2018 Apr;
45(4).
doi: 10.3899/jrheum.170224
PMID: 29335342

Clinical Evolution in Patients With New-Onset Inflammatory Back Pain: A Population-Based Cohort Study.

Wang R, Crowson CS, Wright K, Ward MM
Arthritis & rheumatology (Hoboken, N.J.).
2018 Jul;
70(7).
doi: 10.1002/art.40460
PMID: 29471593

Increased Rates of Both Knee and Hip Arthroplasties in Older Patients with Ankylosing Spondylitis.

Ward MM
The Journal of rheumatology.
2019 Jan;
46(1).
doi: 10.3899/jrheum.171316
PMID: 29961693

Aortic-vertebral interaction in ankylosing spondylitis: syndesmophyte development at the juxta-aortic vertebral rim.

Tan S, Dasgupta A, Flynn JA, Ward MM
Annals of the rheumatic diseases.
2019 Jul;
78(7).
doi: 10.1136/annrheumdis-2018-214675
PMID: 30954970

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Ronnie Gladney

IRP Support Staff
9000 Rockville Pike
Bldg 10, Room 10N311
Bethesda MD 20892
Last Updated: July 2020