Health outcomes represent all physical and social consequences of disease. These include symptoms, functioning, costs, complications of treatment, and mortality.
The overall goals of our research effort are to:
- Understand the factors that influence health outcomes of patients with systemic lupus erythematosus, ankylosing spondylitis, and rheumatoid arthritis.
- Develop new tools and techniques to measure outcomes in these diseases.
- Assess rheumatic disease in an underserved minority community.
- Compare outcomes among patients having orthopedic surgery.
Patient-related factors, such as demographic characteristics, genetic background, and treatment, influence health outcomes. Certain provider-related factors, including access to care, also influence health outcomes. We are studying genetic, clinical, and treatment influences on functional and structural outcomes in ankylosing spondylitis, and provider influences on outcomes in patients with lupus nephritis and hospitalized patients with systemic lupus erythematosus. Among measures of health outcomes, we are testing criteria for clinically important changes in symptoms in patients with rheumatoid arthritis, and are developing methods to quantify the progression of spinal fusion in patients with ankylosing spondylitis. We are examining associations between chronic bisphosphonate use and bone structure and risk of hip fracture.
Tan S, Yao L, Ward MM. Thoracic syndesmophytes commonly occur in the absence of lumbar syndesmophytes in ankylosing spondylitis: a computed tomography study. J Rheumatol. 2017 Dec;44(12):1828-1832. doi: 10.3899/jrheum.170340. Epub 2017 Oct 1.
Tektonidou M, Lewandowski L, Hu J, Dasgupta A, Ward MM. Survival in adults and children with systemic lupus erythematosus. A systematic review and Bayesian meta-analysis of studies from 1950 to 2016. Ann Rheum Dis. 2017 Dec;76(12):2009-2016. doi: 10.1136/annrheumdis-2017-211663. Epub 2017 Aug 9. Review.
Tektonidou MG, Wang Z, Ward MM. Trends in hospitalizations due to acute coronary syndromes and stroke in patients with systemic lupus erythematosus, 1996 to 2012. Arthritis Rheumatol. 2016 Nov;68(11):2680-2685. doi: 10.1002/art.39758.
Tan S, Dasgupta A, Yao J, Flynn JA, Yao L, Ward MM. Spatial distribution of syndesmophytes along the vertebral rim in ankylosing spondylitis: Preferential involvement of the posterolateral rim. Ann Rheum Dis. 2016 Nov;75(11):1951-1957. doi: 10.1136/annrheumdis-2015-208802. Epub 2016 Jan 21.
Wang R, Gabriel SE, Ward MM. Progression of non-radiographic axial spondyloarthritis to ankylosing spondylitis: a population-based cohort study. Arthritis Rheumatol. 2016 Jun;68(6):1415-21. doi: 10.1002/art.39542.
Chen F, Wang Z, Bhattacharyya T. Absence of femoral cortical thickening in long-term bisphosphonate users: implications for atypical femur fractures. Bone. 2014 May;62:64-6. doi: 10.1016/j.bone.2014.01.011. Epub 2014 Jan 25.
Wang Z, Anderson FA Jr, Ward M, Bhattacharyya T. Surgical Site Infections and Other Postoperative Complications following Prophylactic Anticoagulation in Total Joint Arthroplasty. PLoS One. 2014 Apr 9;9(4):e91755. doi: 10.1371/journal.pone.0091755. eCollection 2014.
Ward MM. Estimating disease prevalence and incidence using administrative data: some assembly required. J Rheumatol. 2013 Aug;40(8):1241-3. doi: 10.3899/jrheum.130675.