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Research in NIAMS Labs

Updated March 7, 2017

Illustrated panel showing how the genes reactivate.

Researchers Identify Mechanisms to Improve Nuclear Reprogramming

Researchers from the Laboratory of Muscle Stem Cells and Gene Regulation conducted high-throughput RNA-sequencing of transplanted oocytes to uncover the mechanisms that cause some genes to be resistant to reactivation. The findings, reported in the current issue of Molecular Cell, will help improve the success of nuclear reprogramming.

Photo of Dr. Pinal-Fernandez.

Tofacitinib Shows Potential for Treating Lupus

Dr. Massimo Gadina, chief of the Translational Immunology Section, led a study examining the potential use of tofacitinib for treatment of lupus. Tofacitinib is a JAK inhibitor currently approved for treatment of rheumatoid arthritis. Researchers found that tofacitinib reversed many lupus-associated symptoms, suggesting that this drug, or other JAK inhibitors, shows potential for treating lupus.

Photo of Dr. Pinal-Fernandez.

NIAMS Summer Internship Program

Undergraduate, graduate or professional school students seeking enriching summer research experience can apply to the Summer Internship Program (SIP). The SIP gives qualified students the opportunity to spend 8 weeks conducting research with some of the top biomedical research scientists in the world. Deadline to apply is March 1. Read about the NIAMS 2016 summer interns.

Photo of Dr. Pinal-Fernandez.

Postdoctoral Fellow Receives Research Grant

Congratulations to Dr. Iago Pinal-Fernandez, postdoctoral fellow in the NIAMS Muscle Disease Unit, who received a research grant from The Myositis Association! Dr. Pinal-Fernandez will use next-generation sequencing of RNA from muscle biopsies to analyze the inflammatory mechanisms implicated in different types of myositis.

A slot machine, a metaphor showing neurons being regulated by EZH2 on the lever.

Polycomb Proteins Influence ESC’s Ability to Differentiate

Embryonic stem cells (ESCs) can differentiate into all cell types of the organism. Polycomb proteins influence ESCs' ability to differentiate by methylating specific proteins (histones) that are wrapped with DNA. The Sartorelli lab reports that subtle modifications of Polycomb-mediated histone methylation direct ESCs towards preferential formation of neuronal progenitor cells. Read the study. External Web Site Policy