Yuka Kanno, M.D., Ph.D.

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Contact Information

Summary

Dr. Yuka Kanno’s primary research interest has been the regulation of gene expression by transcription factors. Using JAK-STAT signaling pathway as a model system, she has profiled genome-wide chromatin conformation and gene transcription following STAT activation in immune cells.

Research Statement

Dr. Kanno hopes to understand cell-type specific genomic organization that regulated gene transcription during normal and pathological immune responses, and how extracellular signals influence epigenetic information built in chromatin of immune cells.

Scientific Publications

Remodeling of Il4-Il13-Il5 locus underlies selective gene expression.

Nagashima H, Shayne J, Jiang K, Petermann F, Pękowska A, Kanno Y, O'Shea JJ
Nat Immunol.
2024 Dec;
25(12).
doi: 10.1038/s41590-024-02007-4
PMID: 39567762

Microbial ligand-independent regulation of lymphopoiesis by NOD1.

Iwamura C, Ohnuki H, Flomerfelt FA, Zheng L, Carletti A, Wakashin H, Mikami Y, Brooks SR, Kanno Y, Gress RE, Tosato G, Nakayama T, O'Shea JJ, Sher A, Jankovic D
Nat Immunol.
2023 Dec;
24(12).
doi: 10.1038/s41590-023-01668-x
PMID: 37957354

A central role for STAT5 in the transcriptional programing of T helper cell metabolism.

Villarino AV, Laurence AD, Davis FP, Nivelo L, Brooks SR, Sun HW, Jiang K, Afzali B, Frasca D, Hennighausen L, Kanno Y, O'Shea JJ
Sci Immunol.
2022 Nov 25;
7(77).
doi: 10.1126/sciimmunol.abl9467
PMID: 36427325

The JAK-STAT pathway at 30: Much learned, much more to do.

Philips RL, Wang Y, Cheon H, Kanno Y, Gadina M, Sartorelli V, Horvath CM, Darnell JE Jr, Stark GR, O'Shea JJ
Cell.
2022 Oct 13;
185(21).
doi: 10.1016/j.cell.2022.09.023
PMID: 36240739

MicroRNA-221 and -222 modulate intestinal inflammatory Th17 cell response as negative feedback regulators downstream of interleukin-23.

Mikami Y, Philips RL, Sciumè G, Petermann F, Meylan F, Nagashima H, Yao C, Davis FP, Brooks SR, Sun HW, Takahashi H, Poholek AC, Shih HY, Afzali B, Muljo SA, Hafner M, Kanno Y, O'Shea JJ
Immunity.
2021 Mar 9;
54(3).
doi: 10.1016/j.immuni.2021.02.015
PMID: 33657395

Education

Tohoku University School of Medicine, Sendai, Japan
M.D./Ph.D.

Experience

Resident
NTT Tohoku Hospital, Sendai, Japan

Postdoctoral Fellow
Laboratory of Molecular Growth Regulation, National Institute of Child Health and Human Development, NIH

Instructor
Institute for Virus Research, Kyoto University, Kyoto, Japan

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