Summary

Dr. Yuka Kanno’s primary research interest has been the regulation of gene expression by transcription factors. Using JAK-STAT signaling pathway as a model system, she has profiled genome-wide chromatin conformation and gene transcription following STAT activation in immune cells.

Research Statement

Dr. Kanno hopes to understand cell-type specific genomic organization that regulated gene transcription during normal and pathological immune responses, and how extracellular signals influence epigenetic information built in chromatin of immune cells.

Scientific Publications

Developmental Acquisition of Regulomes Underlies Innate Lymphoid Cell Functionality.

Shih HY, Sciumè G, Mikami Y, Guo L, Sun HW, Brooks SR, Urban JF Jr, Davis FP, Kanno Y, O'Shea JJ
Cell.
2016 May 19;
165(5).
doi: 10.1016/j.cell.2016.04.029
PMID: 27156451

Super-enhancers delineate disease-associated regulatory nodes in T cells.

Vahedi G, Kanno Y, Furumoto Y, Jiang K, Parker SC, Erdos MR, Davis SR, Roychoudhuri R, Restifo NP, Gadina M, Tang Z, Ruan Y, Collins FS, Sartorelli V, O'Shea JJ
Nature.
2015 Apr 23;
520(7548).
doi: 10.1038/nature14154
PMID: 25686607

BRD4 assists elongation of both coding and enhancer RNAs by interacting with acetylated histones.

Kanno T, Kanno Y, LeRoy G, Campos E, Sun HW, Brooks SR, Vahedi G, Heightman TD, Garcia BA, Reinberg D, Siebenlist U, O'Shea JJ, Ozato K
Nature structural & molecular biology.
2014 Dec;
21(12).
doi: 10.1038/nsmb.2912
PMID: 25383670

BACH2 represses effector programs to stabilize T(reg)-mediated immune homeostasis.

Roychoudhuri R, Hirahara K, Mousavi K, Clever D, Klebanoff CA, Bonelli M, Sciumè G, Zare H, Vahedi G, Dema B, Yu Z, Liu H, Takahashi H, Rao M, Muranski P, Crompton JG, Punkosdy G, Bedognetti D, Wang E, Hoffmann V, Rivera J, Marincola FM, Nakamura A, Sartorelli V, Kanno Y, Gattinoni L, Muto A, Igarashi K, O'Shea JJ, Restifo NP
Nature.
2013 Jun 27;
498(7455).
doi: 10.1038/nature12199
PMID: 23728300

STATs shape the active enhancer landscape of T cell populations.

Vahedi G, Takahashi H, Nakayamada S, Sun HW, Sartorelli V, Kanno Y, O'Shea JJ
Cell.
2012 Nov 21;
151(5).
doi: 10.1016/j.cell.2012.09.044
PMID: 23178119

Transcriptional and epigenetic control of T helper cell specification: molecular mechanisms underlying commitment and plasticity.

Kanno Y, Vahedi G, Hirahara K, Singleton K, O'Shea JJ
Annual review of immunology.
2012;
30().
doi: 10.1146/annurev-immunol-020711-075058
PMID: 22224760

Education

Tohoku University School of Medicine, Sendai, Japan
M.D./Ph.D.

Experience

Resident
NTT Tohoku Hospital, Sendai, Japan

Postdoctoral Fellow
Laboratory of Molecular Growth Regulation, National Institute of Child Health and Human Development, NIH

Instructor
Institute for Virus Research, Kyoto University, Kyoto, Japan

Last Updated: July 2020