Subhashree Nayak, Ph.D., Laboratory of Skin Biology, NIAMS

Contact Information

301-402-2888

9000 Rockville Pike

Building 50, Room 1529

Bethesda MD 20892

nayaks2@mail.nih.gov

Summary

Dr. Nayak completed her educational training in different corners of India. She was first introduced to the amazing field of research in 2008 as part of her master's degree dissertation project, and there has been no going back since then. She was trained by Dr. Arijit Mukhopadhyay at the Institute of Genomics and Integrative Biology (IGIB, New Delhi, India) where she studied the molecular genetics of Indian Haemophilia A carriers and Noelin genes in human glaucoma. She later joined his group as a project fellow in 2009 to study comparative genomics of non-coding RNAs. In 2012, she enrolled in the Ph.D. program at the All India Institute of Medical Sciences (AIIMS, New Delhi, India) where she did her doctoral research on clustered microRNAs in human brain tumors in Dr. Chitra Sarkar’s lab in collaboration with IGIB. For post-doctoral training, she joined Dr. Morasso’s lab at NIAMS in December 2017 as a visiting fellow to investigate the epigenetic mechanisms central to skin differentiation.

Research Statement

Dr. Nayak's current research involves deciphering the epigenetic modules that govern the process of skin epidermal differentiation. She utilizes an integrative multi-omics approach to get an unbiased view of the mechanisms involved, followed by knock-out mouse models to establish causality.

Scientific Publications

Chromatin Landscape Governing Murine Epidermal Differentiation.

Nayak S, Jiang K, Hope E, Cross M, Overmiller A, Naz F, Worrell S, Bajpai D, Hasneen K, Brooks SR, Dell'Orso S, Morasso MI

J Invest Dermatol.

2023 Jul;

143(7).

doi: 10.1016/j.jid.2022.12.020

PMID: 36708949

Fusion transcripts in normal human cortex increase with age and show distinct genomic features for single cells and tissues.

Mehani B, Narta K, Paul D, Raj A, Kumar D, Sharma A, Kaurani L, Nayak S, Dash D, Suri A, Sarkar C, Mukhopadhyay A

Sci Rep.

2020 Jan 28;

10(1).

doi: 10.1038/s41598-020-58165-6

PMID: 31992760

SOX2 Epidermal Overexpression Promotes Cutaneous Wound Healing via Activation of EGFR/MEK/ERK Signaling Mediated by EGFR Ligands.

Uchiyama A, Nayak S, Graf R, Cross M, Hasneen K, Gutkind JS, Brooks SR, Morasso MI

J Invest Dermatol.

2019 Aug;

139(8).

doi: 10.1016/j.jid.2019.02.004

PMID: 30772301

Identification of miR-379/miR-656 (C14MC) cluster downregulation and associated epigenetic and transcription regulatory mechanism in oligodendrogliomas.

Kumar A, Nayak S, Pathak P, Purkait S, Malgulawar PB, Sharma MC, Suri V, Mukhopadhyay A, Suri A, Sarkar C

J Neurooncol.

2018 Aug;

139(1).

doi: 10.1007/s11060-018-2840-6

PMID: 29931616

Novel internal regulators and candidate miRNAs within miR-379/miR-656 miRNA cluster can alter cellular phenotype of human glioblastoma.

Nayak S, Aich M, Kumar A, Sengupta S, Bajad P, Dhapola P, Paul D, Narta K, Purkrait S, Mehani B, Suri A, Chakraborty D, Mukhopadhyay A, Sarkar C

Sci Rep.

2018 May 16;

8(1).

doi: 10.1038/s41598-018-26000-8

PMID: 29769662

A-to-I editing in human miRNAs is enriched in seed sequence, influenced by sequence contexts and significantly hypoedited in glioblastoma multiforme.

Paul D, Sinha AN, Ray A, Lal M, Nayak S, Sharma A, Mehani B, Mukherjee D, Laddha SV, Suri A, Sarkar C, Mukhopadhyay A

Sci Rep.

2017 May 26;

7(1).

doi: 10.1038/s41598-017-02397-6

PMID: 28550310

Genome-wide analysis reveals downregulation of miR-379/miR-656 cluster in human cancers.

Laddha SV, Nayak S, Paul D, Reddy R, Sharma C, Jha P, Hariharan M, Agrawal A, Chowdhury S, Sarkar C, Mukhopadhyay A

Biol Direct.

2013 Apr 24;

8().

doi: 10.1186/1745-6150-8-10

PMID: 23618224

A set of five microsatellite markers linked to F8 gene can detect haemophilia A carriers across India.

Saha A, Nayak S, Mani KR, Chandak GR, INDIAN GENOME VARIATION CONSORTIUM, Ray K, Mukhopadhyay A

Haemophilia.

2011 Sep;

17(5).

doi: 10.1111/j.1365-2516.2011.02584.x

PMID: 21696518

Education

Ph.D. in Neuropathology (2012-2017)
AIIMS-IGIB, New Delhi, India

M.Sc. in Bio-medical Genetics (2007-2009)
VIT, Vellore, India

B.Sc. in Microbiology (2004-2007)
OUAT, Bhubaneswar, India

Experience

Post-doctoral Visiting Fellow (2017-2023)
NIAMS, Bethesda, USA

Graduate Student (2012-2017)
AIIMS-IGIB, New Delhi, India

Project Fellow (2009-2012)
IGIB, New Delhi, India