Siddhant Nagar, B.S.

Summary

Siddhant Nagar received his B.S. in Medical Sciences from the University of Cincinnati. While at the University of Cincinnati, Siddhant worked under Dr. Douglas Millay at the Cincinnati Children’s Hospital to study the transcriptional regulation, localization, and functionality of novel genes clustered at the Neuromuscular Junction (NMJ). By using CRISPR/Cas-9 technology and Adeno-Associated Viral (AAV) transfection, he led research characterizing the function of Gramd1 genes in denervated skeletal muscle.

Currently, Siddhant works as a Postbaccalaureate Fellow in the Laboratory of Muscle Stem Cells and Gene Regulation at the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS), under the direction of Dr. Vittorio Sartorelli. He plans to pursue medical school after his tenure at the NIH, with a continued interest in the role of stem cells in disease.

Research Statement

Siddhant’s research in Dr. Satrorelli’s lab aims to understand the epigenetic and metabolic regulators of skeletal muscle stem cell (MuSC) activation and regeneration in dystrophic disease states. Currently, it is known that MuSCs show dysfunction in dystrophic disease states. His work aims to identify the genetic and metabolic mechanisms underlying MuSC dysfunction.

Scientific Publications

The multimodal transcriptional response of denervated skeletal muscle involves regulation of Gramd1 genes impacting muscle size.

Calvo C, Swoboda CO, Montecino-Morales F, Nagar S, Petrany MJ, Sun C, Bindu Durumutla H, Quattrocelli M, Millay DP
Proc Natl Acad Sci U S A.
2025 Sep 30;
122(39).
doi: 10.1073/pnas.2424246122
PMID: 40986355

Education

University of Cincinnati 
B.S., Medical Sciences (2022-2026)

Experience

Postbaccalaureate Fellowship 
The National Institutes of Health (NIAMS) (2026-Present) 

Undergraduate Research Fellow 
Cincinnati Children’s Hospital Medical Center (2022-2026)

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