Dr. Helmold Hait received her Ph.D. degree in Biological Sciences/Genetics in 2014 at the Federal University of Rio de Janeiro in Brazil, where she studied polymorphisms and expression of the Alpha4 Beta7 integrin in HIV (PLWH) positive people at various stages of AIDS disease. During her postdoctoral training at the NCI's Vaccine Branch (2015-2020), she studied T cell and B cell maturation and function during HIV vaccination and infection with SHIV. During her Research Fellowship at the Vaccine Research Center/NIAID (2020-2023), she investigated the mechanism of CD4 T cell activation and the effect of broadly neutralizing antibodies against HIV in SHIV-infected Rhesus Macaques and PLWH. In 2023, she joined the NIAMS Translational Immunology Section (TIS) where she supports clinical studies by providing advice and conducting experiments involving cellular immunophenotyping and p-STAT phospho-flow assays using samples from patients with different inflammatory diseases.

Research Statement

Currently, Dr. Helmold Hait's research focuses on the JAK/STAT signaling pathway and the characterization of immune cell dysregulation in autoimmune and inflammatory diseases using flow cytometry.

Scientific Publications

Trispecific antibody targeting HIV-1 and T cells activates and eliminates latently-infected cells in HIV/SHIV infections.

Promsote W, Xu L, Hataye J, Fabozzi G, March K, Almasri CG, DeMouth ME, Lovelace SE, Talana CA, Doria-Rose NA, McKee K, Hait SH, Casazza JP, Ambrozak D, Beninga J, Rao E, Furtmann N, Birkenfeld J, McCarthy E, Todd JP, Petrovas C, Connors M, Hebert AT, Beck J, Shen J, Zhang B, Levit M, Wei RR, Yang ZY, Pegu A, Mascola JR, Nabel GJ, Koup RA
Nat Commun.
2023 Jun 22;
doi: 10.1038/s41467-023-39265-z
PMID: 37349337

Anti-viral efficacy of a next-generation CD4-binding site bNAb in SHIV-infected animals in the absence of anti-drug antibody responses.

Lovelace SE, Helmold Hait S, Yang ES, Fox ML, Liu C, Choe M, Chen X, McCarthy E, Todd JP, Woodward RA, Koup RA, Mascola JR, Pegu A
2022 Oct 21;
doi: 10.1016/j.isci.2022.105067
PMID: 36157588

Ultrapotent antibodies against diverse and highly transmissible SARS-CoV-2 variants.

Wang L, Zhou T, Zhang Y, Yang ES, Schramm CA, Shi W, Pegu A, Oloniniyi OK, Henry AR, Darko S, Narpala SR, Hatcher C, Martinez DR, Tsybovsky Y, Phung E, Abiona OM, Antia A, Cale EM, Chang LA, Choe M, Corbett KS, Davis RL, DiPiazza AT, Gordon IJ, Hait SH, Hermanus T, Kgagudi P, Laboune F, Leung K, Liu T, Mason RD, Nazzari AF, Novik L, O'Connell S, O'Dell S, Olia AS, Schmidt SD, Stephens T, Stringham CD, Talana CA, Teng IT, Wagner DA, Widge AT, Zhang B, Roederer M, Ledgerwood JE, Ruckwardt TJ, Gaudinski MR, Moore PL, Doria-Rose NA, Baric RS, Graham BS, McDermott AB, Douek DC, Kwong PD, Mascola JR, Sullivan NJ, Misasi J
2021 Aug 13;
doi: 10.1126/science.abh1766
PMID: 34210892

T(FH) Cells Induced by Vaccination and Following SIV Challenge Support Env-Specific Humoral Immunity in the Rectal-Genital Tract and Circulation of Female Rhesus Macaques.

Helmold Hait S, Hogge CJ, Rahman MA, Hunegnaw R, Mushtaq Z, Hoang T, Robert-Guroff M
Front Immunol.
doi: 10.3389/fimmu.2020.608003
PMID: 33584682

An SAMT-247 Microbicide Provides Potent Protection against Intravaginal Simian Immunodeficiency Virus Infection of Rhesus Macaques, whereas an Added Vaccine Component Elicits Mixed Outcomes.

Helmold Hait S, Hogge CJ, Rahman MA, Ko EJ, Hunegnaw R, Mushtaq Z, Enyindah-Asonye G, Hoang T, Miller Jenkins LM, Appella E, Appella DH, Robert-Guroff M
J Immunol.
2020 Jun 15;
doi: 10.4049/jimmunol.2000165
PMID: 32393514

Early T Follicular Helper Cell Responses and Germinal Center Reactions Are Associated with Viremia Control in Immunized Rhesus Macaques.

Helmold Hait S, Vargas-Inchaustegui DA, Musich T, Mohanram V, Tuero I, Venzon DJ, Bear J, Rosati M, Vaccari M, Franchini G, Felber BK, Pavlakis GN, Robert-Guroff M
J Virol.
2019 Feb 15;
doi: 10.1128/JVI.01687-18
PMID: 30463978


Federal University of Rio De Janeiro
Ph.D., Biomedical Science/Genetics (2010-2014)

Federal University of Rio De Janeiro
M.S., Biomedical Science/Genetics (2009-2010)

B.S., Biomedicine (2005-2008)



Research Fellowship
Vaccine Research Center/NIAID/NIH (2020-2023)

Postdoctoral Fellowship
National Cancer Institute/NIH (2015-2020)

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