Pawel Trzaskoma, Ph.D.

Dr. Pawel Trzaskoma earned his Ph.D. in Cell Biology in 2019, focusing on the spatial organization of the human genome. His research lies at the intersection of super-resolution microscopy, 3D electron microscopy, chromatin architecture, and transcriptional regulation. He is particularly interested in how the three-dimensional structure of chromatin influences gene expression programs in health and disease.

Dr. Trzaskoma uses single-cell RNA sequencing and advanced imaging approaches to investigate gene expression variability and transcriptional dynamics at the single-cell level. His research aims to deepen our understanding of how genome organization at multiple scales—ranging from enhancer-promoter interactions to higher-order chromatin architecture—affects cellular identity and responses to environmental cues.

At NIAMS, Dr. Trzaskoma works in interdisciplinary projects integrating quantitative imaging, single-cell transcriptomics, and computational modeling to study the principles governing transcriptional bursting and epigenetic regulation. His long-term goal is to uncover how spatial genome organization contributes to cell-type-specific gene regulation and how its disruption may lead to disease.