Paul M. Panipinto, Ph.D.

Summary

Paul Panipinto, Ph.D., completed his undergraduate studies at the University of Washington's Molecular, Cellular, and Developmental Biology program. He then started work as a research scientist in the lab of Dr. Erika Noss at the Division of Rheumatology. There, he worked on a variety of projects related to fibroblast biology, including inflammatory signaling mechanisms in platelet-derived growth factor receptors, the identification of pathogenic subsets of fibroblasts in osteo- and rheumatoid arthritis (RA), and inflammatory mechanisms of inflammatory bowel disease.

Dr. Panipinto's work in Dr. Noss's lab developed his interest in furthering his education, and from there, he joined the lab of Dr. Salah Ahmed at Washington State University's College of Pharmacy and Pharmaceutical Science. His work included identifying the extracellular sulfatase Sulf-2's participation in TNFα mediated signaling in RA and investigations into the mechanism of inhibition of several small molecule kinase inhibitors. 

Dr. Panipinto's F-31-funded thesis project focused on inhibiting the kinase TAK-1, which sits at the nexus of the NF-κB and MAPK pathways.

Research Statement

Dr. Panipinto's research at the NIH focuses on systemic juvenile arthritis and adult-onset Still's disease. His particular interest is innate immunity and mechanisms of inflammation in rare genetic disease variants.

Scientific Publications

Molecular basis for the recognition of 24-(S)-hydroxycholesterol by integrin αvβ3.

Gc JB, Chen J, Pokharel SM, Mohanty I, Mariasoosai C, Obi P, Panipinto P, Bandyopadhyay S, Bose S, Natesan S
Sci Rep.
2023 Jun 6;
13(1).
doi: 10.1038/s41598-023-36040-4
PMID: 37280310

Extracellular sulfatase-2 is overexpressed in rheumatoid arthritis and mediates the TNF-α-induced inflammatory activation of synovial fibroblasts.

Siegel RJ, Singh AK, Panipinto PM, Shaikh FS, Vinh J, Han SU, Kenney HM, Schwarz EM, Crowson CS, Khuder SA, Khuder BS, Fox DA, Ahmed S
Cell Mol Immunol.
2022 Oct;
19(10).
doi: 10.1038/s41423-022-00913-x
PMID: 36068294

Takinib Inhibits Inflammation in Human Rheumatoid Arthritis Synovial Fibroblasts by Targeting the Janus Kinase-Signal Transducer and Activator of Transcription 3 (JAK/STAT3) Pathway.

Panipinto PM, Singh AK, Shaikh FS, Siegel RJ, Chourasia M, Ahmed S
Int J Mol Sci.
2021 Nov 22;
22(22).
doi: 10.3390/ijms222212580
PMID: 34830460

Multiparameter Analysis Identifies Heterogeneity in Knee Osteoarthritis Synovial Responses.

Labinsky H, Panipinto PM, Ly KA, Khuat DK, Madarampalli B, Mahajan V, Clabeaux J, MacDonald K, Verdin PJ, Buckner JH, Noss EH
Arthritis Rheumatol.
2020 Apr;
72(4).
doi: 10.1002/art.41161
PMID: 31702112

Interactions between cadherin-11 and platelet-derived growth factor receptor-alpha signaling link cell adhesion and proliferation.

Madarampalli B, Watts GFM, Panipinto PM, Nguygen HN, Brenner MB, Noss EH
Biochim Biophys Acta Mol Basis Dis.
2019 Jun 1;
1865(6).
doi: 10.1016/j.bbadis.2019.03.001
PMID: 30876808

Education

University of Washington 
B.S. in Cellular and Molecular Biology (2014-2017)

Washington State University 
Ph.D. in Pharmaceutical Science and Molecular Medicine (2019-2024)

Experience

Research Scientist 
University of Washington Division of Rheumatology (2017-2019)

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