Mariana Correia Marques, M.D.

Lawrence Shulman Scholar in Translational Research

Translational Genetics and Genomics Section

Summary

Mariana Correia Marques, M.D., is a Lawrence Shulman Scholar in Translational Research at the NIAMS. She completed her medical school training at the Universidade de Brasília (UnB) and did her first pediatrics residency at the Universidade de São Paulo (USP), both in Brazil. Dr. Correia Marques then moved to the United States and did a second residency in pediatrics at the Boston Combined Residency Program. She did her first year of pediatric rheumatology fellowship at the University of Pittsburgh. Dr. Correia Marques transferred as a second year to the combined Children’s National Hospital program and the National Institutes of Health (NIH).

Dr. Correia Marques has been passionate about research in systemic juvenile idiopathic arthritis (sJIA) since her fellowship when she encountered several patients with the condition who had been refractory to all the available treatments. These patients motivated her to focus on translational research in sJIA.

Research Statement

Dr. Correia Marques started working with Dr. Michael Ombrello at NIAMS to understand the genetic background of patients with sJIA, with the final objective of identifying potential pathways for targeted therapy. During her fellowship, she studied the role of variants in genes associated with familial forms of hemophagocytic lymphohistiocytosis (HLH) in patients with sJIA. She has also worked with patient-led organizations to develop a survey to identify the tolerability of the COVID-19 vaccine in patients with sJIA.

In recognition of her work, in 2023, she was awarded one of the Distinguished Fellow Awards by the American College of Rheumatology. As a NIAMS Scholar in Translational Research, Dr. Correia Marques will continue her pursuit to understand the mechanisms that drive sJIA and contribute to treatment-refractory disease courses.

Scientific Publications

Enrichment of Rare Variants of Hemophagocytic Lymphohistiocytosis Genes in Systemic Juvenile Idiopathic Arthritis.

Correia Marques M, Rubin D, Shuldiner EG, Datta M, Schmitz E, Gutierrez Cruz G, Patt A, Bennett E, Grom A, Foell D, Gattorno M, Bohnsack J, Yeung RSM, Prahalad S, Mellins E, Anton J, Len CA, Oliveira S, Woo P, Ozen S, Deng Z, Ombrello MJ, INCHARGE Consortium
Arthritis Rheumatol.
2024 Oct;
76(10).
doi: 10.1002/art.42938
PMID: 38937141

New discoveries in the genetics and genomics of systemic juvenile idiopathic arthritis.

Correia Marques M, Ombrello MJ, Schulert GS
Expert Rev Clin Immunol.
2024 Sep;
20(9).
doi: 10.1080/1744666X.2024.2345868
PMID: 38641907

"Online survey of COVID-19 immunization and infection in patients with systemic juvenile idiopathic arthritis and adult-onset still's disease.".

Marques MC, Paul S, Lake C, Bergeron LL, Sinha R, Peixoto L, Twilt M, Ombrello MJ
Pediatr Rheumatol Online J.
2023 Nov 21;
21(1).
doi: 10.1186/s12969-023-00911-x
PMID: 37990257

Increase in pediatric recurrent fever evaluations during the first year of the COVID-19 pandemic in North America.

Mansfield LM, Lapidus SK, Romero SN, Moorthy LN, Adler-Shohet FC, Hollander M, Cherian J, Twilt M, Lionetti G, Mohan S, DeLaMora PA, Durrant KL, Muskardin TW, Correia Marques M, Onel KB, Dedeoglu F, Gutierrez MJ, Schulert G, CARRA Autoinflammatory Network Consortium for the CARRA PFAPA/Autoinflammatory Working Group
Front Pediatr.
2023;
11().
doi: 10.3389/fped.2023.1240242
PMID: 37601132

NEMO-NDAS: A Panniculitis in the Young Representing an Autoinflammatory Disorder in Disguise.

Hegazy S, Marques MC, Canna SW, Goldbach-Mansky R, de Jesus AA, Reyes-Múgica M, Salgado CM
Am J Dermatopathol.
2022 Jun 1;
44(6).
doi: 10.1097/DAD.0000000000002144
PMID: 35120036

Cross-sectional characteristics of pediatric-onset discoid lupus erythematosus: Results of a multicenter, retrospective cohort study.

Ezeh N, Ardalan K, Buhr KA, Nguyen C, Al Ahmed O, Ardoin SP, Barton V, Bell S, Brandling-Bennett H, Castelo-Soccio L, Chiu YE, Chong BF, Co DO, Lara-Corrales I, Cintosun A, Curran ML, Diaz LZ, Elman SA, Faith EF, Garcia-Romero MT, Grossman-Kranseler J, Hogeling M, Hudson AD, Hunt RD, Ibler EM, Marques MC, Monir RL, Oza V, Paller AS, Putterman E, Rodriguez-Salgado P, Schoch JJ, Truong A, Wang J, Lee LW, Vleugels RA, Klein-Gitelman MS, von Scheven E, Werth VP, Arkin LM
J Am Acad Dermatol.
2022 Sep;
87(3).
doi: 10.1016/j.jaad.2022.04.028
PMID: 35487332

Features predicting colchicine efficacy in treatment of children with undefined systemic autoinflammatory disease: A retrospective cohort study.

Marques MC, Egeli BH, Wobma H, Ribeiro C, Anderson E, Hausmann JS, Dedeoğlu F
Eur J Rheumatol.
2022 Jul;
9(3).
doi: 10.5152/eurjrheum.2022.21135
PMID: 35156637

Consensus treatment plans for periodic fever, aphthous stomatitis, pharyngitis and adenitis syndrome (PFAPA): a framework to evaluate treatment responses from the childhood arthritis and rheumatology research alliance (CARRA) PFAPA work group.

Amarilyo G, Rothman D, Manthiram K, Edwards KM, Li SC, Marshall GS, Yildirim-Toruner C, Haines K, Ferguson PJ, Lionetti G, Cherian J, Zhao Y, DeLaMora P, Syverson G, Nativ S, Twilt M, Michelow IC, Stepanovskiy Y, Thatayatikom A, Harel L, Akoghlanian S, Tucker L, Marques MC, Srinivasalu H, Propst EJ, Licameli GR, Dedeoglu F, Lapidus S, CARRA PFAPA Consensus Treatment Plan Workgroup
Pediatr Rheumatol Online J.
2020 Apr 15;
18(1).
doi: 10.1186/s12969-020-00424-x
PMID: 32293478

Anti-RO/SSA and anti-La/SSB antibodies: Association with mild lupus manifestations in 645 childhood-onset systemic lupus erythematosus.

Novak GV, Marques M, Balbi V, Gormezano NW, Kozu K, Sakamoto AP, Pereira RM, Terreri MT, Magalhães CS, Guariento A, Sallum AM, Marini R, Ferriani VP, Barbosa CM, de Castro TC, Ramos VC, Bonfá E, Silva CA
Autoimmun Rev.
2017 Feb;
16(2).
doi: 10.1016/j.autrev.2016.12.004
PMID: 27988434

Education

Universidade de Brasília
M.D. (2014)

Experience

National Institute of Arthritis and Musculoskeletal and Skin Diseases, NIH
Lawrence Shulman Scholar in Translational Research (2023 - Present)

NIH/Children's National Hospital
Fellowship in Pediatric Rheumatology (2023)

University of Pittsburgh Medical Center Children's Hospital of Pittsburgh
Fellowship in Pediatric Rheumatology (1st year, 2021)

Boston Combined Residency Program
Residency in Pediatrics (2020)

Universidade de São Paulo
Residency in Pediatrics (2017)

Last Updated: