Krisztian Csomos, Ph.D.

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Summary

Krisztian Csomos, Ph.D., is a research fellow in the Translational Genetics and Genomics Section at NIAMS, NIH. Originally from Hungary, he earned his Ph.D. in immunology in 2011, completed his postdoctoral training at Massachusetts General Hospital in Boston, and then served first as a postdoctoral scholar and later as a research faculty member at the University of South Florida in Tampa. He joined the NIH as a research fellow in 2024.

Dr. Csomos integrates single-cell genomics, high-parameter spectral flow cytometry, and in vitro functional assays to investigate the cellular and molecular mechanisms driving autoimmune and autoinflammatory diseases.

Research Statement

Dr. Csomos’ research focuses on defining how innate and adaptive immune pathways become dysregulated in both monogenic and polygenic inflammatory and autoimmune diseases. In the Translational Genetics and Genomics Section, his work employs state-of-the-art cellular, molecular, and computational approaches to dissect how genetic variation and inflammatory environments reshape human immune function.

By directly mapping dysfunctional immune circuits in patient-derived samples, Dr. Csomos aims to identify the mechanisms that drive systemic inflammation in conditions such as Still’s disease and related autoinflammatory disorders.

His long-term goal is to translate these insights into improved molecular classification, targeted therapies, and precision immunology approaches for patients with genetically complex inflammatory disease.

Scientific Publications

Simultaneous STING and lymphotoxin-β receptor activation induces B cell responses in tertiary lymphoid structures to potentiate antitumor immunity.

Sawada J, Kikuchi Y, Duah M, Herrera JL, Kanamori F, Csomos K, Stansel T, Hiraoka N, Yoshida M, Walter J, Ware CF, Komatsu M
Nat Immunol.
2025 Oct;
26(10).
doi: 10.1038/s41590-025-02259-8
PMID: 40897896

B cell abnormalities and autoantibody production in patients with partial RAG deficiency.

Min Q, Csomos K, Li Y, Dong L, Hu Z, Meng X, Yu M, Walter JE, Wang JY
Front Immunol.
2023;
14().
doi: 10.3389/fimmu.2023.1155380
PMID: 37475856

Dysregulated stem cell niches and altered lymphocyte recirculation cause B and T cell lymphopenia in WHIM syndrome.

Zehentmeier S, Lim VY, Ma Y, Fossati J, Ito T, Jiang Y, Tumanov AV, Lee HJ, Dillinger L, Kim J, Csomos K, Walter JE, Choi J, Pereira JP
Sci Immunol.
2022 Sep 23;
7(75).
doi: 10.1126/sciimmunol.abo3170
PMID: 36149943

Partial RAG deficiency in humans induces dysregulated peripheral lymphocyte development and humoral tolerance defect with accumulation of T-bet(+) B cells.

Csomos K, Ujhazi B, Blazso P, Herrera JL, Tipton CM, Kawai T, Gordon S, Ellison M, Wu K, Stowell M, Haynes L, Cruz R, Zakota B, Nguyen J, Altrich M, Geier CB, Sharapova S, Dasso JF, Leiding JW, Smith G, Al-Herz W, de Barros Dorna M, Fadugba O, Fronkova E, Kanderova V, Svaton M, Henrickson SE, Hernandez JD, Kuijpers T, Kandilarova SM, Naumova E, Milota T, Sediva A, Moshous D, Neven B, Saco T, Sargur R, Savic S, Sleasman J, Sunkersett G, Ward BR, Komatsu M, Pittaluga S, Kumanovics A, Butte MJ, Cancro MP, Pillai S, Meffre E, Notarangelo LD, Walter JE
Nat Immunol.
2022 Aug;
23(8).
doi: 10.1038/s41590-022-01271-6
PMID: 35902638

Prevalence and clinical challenges among adults with primary immunodeficiency and recombination-activating gene deficiency.

Lawless D, Geier CB, Farmer JR, Lango Allen H, Thwaites D, Atschekzei F, Brown M, Buchbinder D, Burns SO, Butte MJ, Csomos K, Deevi SVV, Egner W, Ehl S, Eibl MM, Fadugba O, Foldvari Z, Green DM, Henrickson SE, Holland SM, John T, Klemann C, Kuijpers TW, Moreira F, Piller A, Rayner-Matthews P, Romberg ND, Sargur R, Schmidt RE, Schröder C, Schuetz C, Sharapova SO, Smith KGC, Sogkas G, Speckmann C, Stirrups K, Thrasher AJ, Wolf HM, Notarangelo LD, Anwar R, Boyes J, Ujhazi B, NIHR BioResource–Rare Diseases Consortium, Thaventhiran J, Walter JE, Savic S
J Allergy Clin Immunol.
2018 Jun;
141(6).
doi: 10.1016/j.jaci.2018.02.007
PMID: 29477728

Broad-spectrum antibodies against self-antigens and cytokines in RAG deficiency.

Walter JE, Rosen LB, Csomos K, Rosenberg JM, Mathew D, Keszei M, Ujhazi B, Chen K, Lee YN, Tirosh I, Dobbs K, Al-Herz W, Cowan MJ, Puck J, Bleesing JJ, Grimley MS, Malech H, De Ravin SS, Gennery AR, Abraham RS, Joshi AY, Boyce TG, Butte MJ, Nadeau KC, Balboni I, Sullivan KE, Akhter J, Adeli M, El-Feky RA, El-Ghoneimy DH, Dbaibo G, Wakim R, Azzari C, Palma P, Cancrini C, Capuder K, Condino-Neto A, Costa-Carvalho BT, Oliveira JB, Roifman C, Buchbinder D, Kumanovics A, Franco JL, Niehues T, Schuetz C, Kuijpers T, Yee C, Chou J, Masaad MJ, Geha R, Uzel G, Gelman R, Holland SM, Recher M, Utz PJ, Browne SK, Notarangelo LD
J Clin Invest.
2015 Nov 2;
125(11).
doi: 10.1172/JCI80477
PMID: 26457731

Education

University of Debrecen, Hungary 
Ph.D in Immunology (2004 - 2011)

University of Debrecen, Hungary 
M.Sc. in Molecular Biology (1999 - 2004) 

Experience

Research Associate 
University of South Florida, Tampa, FL (2018 - 2023)

Postdoctoral Fellowship 
University of South Florida, Tampa, FL (2016 - 2018) 

Postdoctoral Fellowship 
Massachusetts General Hospital, Boston, MA (2013 - 2016) 

Postdoctoral Fellowship 
University of Debrecen, Hungary (2011 - 2013) 

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