Contact Information
Summary
Dr. Tinsley obtained his undergrad and master's degrees from Washington University in St. Louis. His master's thesis examined the mechanism behind the profound depletion of lymphocytes observed in septic patients and helped establish a new paradigm for explaining the underlying pathology of sepsis. He completed his Ph.D. at The George Washington University, studying the role of the CD4 co-receptor in regulating Restimulation Induced Cell Death.
After earning his Ph.D., Dr. Tinsley completed his post-doctoral training at the National Cancer Institute, NIH, where he investigated the transcription factor Ikaros and identified a new role for the protein in suppressing the proliferative potential of TCR signaling as well as promoting survival and differentiation of positively selected thymocytes. He then joined NIAMS in Dr. Juan Rivera's laboratory before finally obtaining his current position as a staff scientist in the flow cytometry core facility.
Research Statement
Currently, Dr. Tinsley is interested in analyzing large data sets using the computer languages R and Python. Advances in flow cytometry, such as large fluorescent panels and full-spectrum cytometers, are being driven by developments in data analysis utilizing machine learning processes such as Uniform Manifold Approximation (UMAP) and t-distributed Stochastic Neighbor Emulation (t-SNE).
Additionally, Dr. Tinsley helps maintain the flow core's conventional and full-spectrum analyzers and runs cell sorting experiments for NIAMS investigators.
Education
The George Washington University
Immunology (2009)
Washington University in St. Louis
Biology (2003)
Washington University in St. Louis
Biology (1998)
Experience
Staff Scientist
NIAMS, NIH (2015-Present)
Biologist, Contractor position
NIAMS, NIH (2010-2015)
Post Doctoral Fellow
NCI, NIH (2009-2010)