Hong Jun Wang received her Ph.D. from McGill University, Canada, where she studied the function and regulation of a new histone deacetylase 4 (HDAC4). Dr. Wang started her postdoctoral training with Dr. Rik Derynck at UCSF, studying histone modification in TGF-beta/SMAD3 repressed muscle differentiation. She also studied the regulation of TGF-beta and BMP signaling pathways by protein arginine methylation of SMAD6. Dr. Wang continued her postdoctoral research with Dr. Vittorio Sartorelli at the NIAMS, focusing on transcriptional regulation of skeletal muscle differentiation and embryonic stem cell pluripotency and self-renewal. In 2016, she moved to the NIDCD as a contractor working on restoring genetic hearing loss by AAV-delivered CRISPR/Cas9 system. Dr. Wang returned to the NIAMS in 2020, and currently works with Dr. Sartorelli as a biologist in the Laboratory of Muscle Stem Cells and Gene Regulation.
Dr. Wang’s research focuses on the role of histone methyltransferase Ezh1 in skeletal muscle differentiation, regeneration of adult skeletal muscle, and metabolic regulation of epigenetics.