Chun-Ting (Justin) Kwong, M.D.

Postdoctoral Research Fellow (Visiting)

Systemic Autoimmunity Branch

Summary

Justin Kwong, M.D., completed a bachelor of biomedicine (degree with honors) at the University of Melbourne in 2018 with dual majors in immunology and microbiology. His honors thesis investigated the therapeutic potential of interleukin-7 blockade in a pre-clinical model of autoimmune diabetes. He subsequently pursued a doctor of medicine at the University of Sydney from 2019 to 2022, where his research led to the characterization of predictive immune signatures in the blood of oncology patients undergoing checkpoint inhibitor therapy. Before his current role at NIH, his clinical duties involved working as a resident medical officer in rural Australia, rotating predominantly through orthopedic surgery.

Research Statement

Dr. Kwong’s current research involves determining neutrophil biology in the context of rheumatoid arthritis and other autoimmune conditions. He utilizes technologies such as single-cell RNA sequencing to understand the transcriptional landscape of infiltrating and circulating neutrophils in active disease. He is also interested in understanding the underlying mechanisms of neutrophil development implicated in the dysregulation of peripheral tolerance.

Scientific Publications

Tolerance to Proinsulin-1 Reduces Autoimmune Diabetes in NOD Mice.

Jhala G, Selck C, Chee J, Kwong CJ, Pappas EG, Thomas HE, Kay TWH, Krishnamurthy B
Front Immunol.
2021;
12().
doi: 10.3389/fimmu.2021.645817
PMID: 33841427

Deficiency of the innate immune adaptor STING promotes autoreactive T cell expansion in NOD mice.

Akazawa S, Mackin L, Jhala G, Fynch S, Catterall T, Selck C, Graham KL, Krishnamurthy B, Pappas EG, Kwong CJ, Sutherland APR, Kay TWH, Brodnicki TC, Thomas HE
Diabetologia.
2021 Apr;
64(4).
doi: 10.1007/s00125-020-05378-z
PMID: 33483762

Harnessing CD8(+) T-cell exhaustion to treat type 1 diabetes.

Kwong CJ, Selck C, Tahija K, McAnaney LJ, Le DV, Kay TW, Thomas HE, Krishnamurthy B
Immunol Cell Biol.
2021 May;
99(5).
doi: 10.1111/imcb.12444
PMID: 33548057

Extraislet expression of islet antigen boosts T cell exhaustion to partially prevent autoimmune diabetes.

Selck C, Jhala G, De George DJ, Kwong CJ, Christensen MK, Pappas EG, Liu X, Ge T, Trivedi P, Kallies A, Thomas HE, Kay TWH, Krishnamurthy B
Proc Natl Acad Sci U S A.
2024 Feb 6;
121(6).
doi: 10.1073/pnas.2315419121
PMID: 38285952

Education

University of Sydney 
Doctor of Medicine - M.D. (2019-2022) 

University of Melbourne 
Bachelor of Biomedicine (degree with honors) (2015-2018)

Experience

Intern and Resident Medical Officer 
Orange Health Service, New South Wales, Australia (2023-2024) 

Research Assistant 
Charles Perkins Centre, New South Wales, Australia (2019-2020)

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