Brinda Bhatt, Ph.D., M.S., Functional Immunogenomics Section, NIAMS

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Summary

Brinda Bhatt, Ph.D., double majored in Biology and Classical Civilizations and completed her bachelor's degree at Emory University. She went on to earn a master's degree in Molecular Microbiology and Immunology from the Keck School of Medicine at the University of Southern California, interrogating the influence of diet and air pollution on the development of obesity. Subsequently, Dr. Bhatt studied immune function in the contexts of colonic inflammation and signaling in CD8 T cells, fulfilling the requirements for a Ph.D. from The Graduate School at Augusta University. In 2021, she joined the NIH as a Postdoctoral Fellow at the NIAMS.

Research Statement

Dr. Bhatt’s research focuses on the molecular mechanisms of glucocorticoid receptor (GR) signaling and localization in primary cells. While these mechanisms have been extensively studied in the past, experiments were largely confined to work in cancer cell lines. Dr. Bhatt takes advantage of technological advances to examine patterns in GR signaling in primary cells to better understand receptor signaling in vivo. Her work utilizes confocal and high-throughput imaging, pulse chase, and genomics and proteomics approaches.

Scientific Publications

Endogenous glucocorticoids and human immunity: Time to revisit old dogmas.

Bhatt B, Franco LM

Semin Immunol.

2025 Jun;

78().

doi: 10.1016/j.smim.2025.101949

PMID: 40203674

UFL1 promotes survival and function of virtual memory CD8 T cells.

Bhatt B, Kumar K, Shi H, Ganesan D, Anazodo F, Rathakrishnan A, Zhu H, Wanna A, Jiang C, Jayavelu T, Lokeshwar VB, Pacholczyk R, Munn DH, Sheridan BS, Moskophidis D, Li H, Singh N

J Immunol.

2025 Mar 1;

214(3).

doi: 10.1093/jimmun/vkae042

PMID: 40073095

Role of G-Protein Coupled Receptors in Chemotaxis of Innate Lymphoid Cells.

Bhatt B, Zhu H, Patel N, Singh N

Methods Mol Biol.

2020;

2121().

doi: 10.1007/978-1-0716-0338-3_9

PMID: 32147789

Ufbp1 promotes plasma cell development and ER expansion by modulating distinct branches of UPR.

Zhu H, Bhatt B, Sivaprakasam S, Cai Y, Liu S, Kodeboyina SK, Patel N, Savage NM, Sharma A, Kaufman RJ, Li H, Singh N

Nat Commun.

2019 Mar 6;

10(1).

doi: 10.1038/s41467-019-08908-5

PMID: 30842412

Gpr109a Limits Microbiota-Induced IL-23 Production To Constrain ILC3-Mediated Colonic Inflammation.

Bhatt B, Zeng P, Zhu H, Sivaprakasam S, Li S, Xiao H, Dong L, Shiao P, Kolhe R, Patel N, Li H, Levy-Bercowski D, Ganapathy V, Singh N

J Immunol.

2018 Apr 15;

200(8).

doi: 10.4049/jimmunol.1701625

PMID: 29514953

Carbidopa, a drug in use for management of Parkinson disease inhibits T cell activation and autoimmunity.

Zhu H, Lemos H, Bhatt B, Islam BN, Singh A, Gurav A, Huang L, Browning DD, Mellor A, Fulzele S, Singh N

PLoS One.

2017;

12(9).

doi: 10.1371/journal.pone.0183484

PMID: 28898256

Education

Augusta University
Ph.D., Biochemistry and Cancer Biology (2020)

University of Southern California
M.S., Molecular Microbiology and Immunology (2013)

Emory University
B.S., Biology (2011)

Experience

Postdoctoral Fellowship
NIAMS, NIH, MD (2021-present)

Graduate Research Assistant
Augusta University, GA (2015-2020)

Graduate Research Assistant
University of Southern California, CA (2011-2013)