This program supports basic and translational research in the repair, regeneration, and restoration of function of injured and/or diseased musculoskeletal tissues using stem cell biology and engineering-based approaches. These tissues include bone, cartilage, tendon, ligament, menisci, muscle and intervertebral discs. Multi- and inter- disciplinary research teams with expertise in biological and physical sciences and cross-training for emerging scientists are encouraged.

Areas of supported research include the following:

• Understanding
  • Pathways of human organogenesis - how cells self-assemble into complex tissues in vitro and in vivo.
  • Cellular processes of mammalian stem and progenitor cells - controlling survival, differentiation, proliferation, migration, senescence, and responses to stimuli.
  • Role of inflammation and responses to immune signals.
• Engineering
  • Smart scaffolds for structural, mechanical, and functional support.
  • Micro environment to promote repair and regeneration.
• Developing effective strategies to
  • Recruit and direct endogenous progenitor or stem cells.
  • Integrate engineered tissues with the host while reducing adverse effects (e.g., immunogenicity, toxicity).
  • Improve molecular, cellular, or gene-based therapies.
• Building tools for
  • Cell optimization and scale-up.
  • 3-D fabrication.
  • Tissue preservation and storage.
  • Real-time, non-invasive modalities to track cells, and/or monitor tissue-function repair and integration process in vivo.
• Establish models, such as:
  • 3-D human tissue models for drug screening or studying pathophysiological processes.
  • Preclinical models to promote direct clinical translation.
• Exploring cross-talk between regeneration and rehabilitation to restore functions.