Taegyun Kim, M.D., Ph.D.

Summary

Taegyun Kim, M.D., Ph.D., completed his dermatology residency at Yonsei University College of Medicine, Severance Hospital, and completed a physician-scientist M.D., Ph.D. program at the same institution. He became a visiting fellow in Dr. Anandasabapathy's Lab at Harvard Medical School, where he studied cellular and molecular mechanisms for dendritic cell-mediated tissue immune tolerance. 

In 2021, Dr. Kim was appointed assistant professor (tenured) of the Department of Dermatology, Severance Hospital, Yonsei University College of Medicine, Seoul, South Korea. Dr. Kim joined the Cutaneous Leukocyte Biology Section at NIAMS in 2024 as a visiting scholar.

Research Statement

During his dermatology residency and clinical fellowship training, Dr. Kim investigated the immunophenotype of pathogenic dendritic cell subsets in psoriatic inflammation (J Invest Dermatol, 2014; J Invest Dermatol, 2018). During his M.D-Ph.D. training, he found that the epigenetic molecule CCCTC-binding factor controls the maintenance of self-perpetuating immune cell populations, such as epidermal Langerhans cells and hematopoietic stem cells (J Allergy Clin Immunol, 2015; Exp Mol Med, 2017).

Dr. Kim's current research focuses on basic and translational questions obtained from clinical practice to understand the pathogenic immune circuit and memory that drive the chronic recurrent features of inflammatory skin disorders. These disorders include psoriasis, recalcitrant eczema, and autoimmune rheumatic skin diseases in the context of cellular communication (J Allergy Clin Immunol, 2023; EBioMedicine, 2024; Cell Rep, 2024). Furthermore, he seeks to understand how the skin immune microenvironment communicates as a network within the skin about the close interaction with the outside world, such as the microbiome (Cell Host Microbe, 2024).

Scientific Publications

Tonic type 2 immunity is a critical tissue checkpoint controlling autoimmunity in the skin.

Lee JE, Kim M, Ochiai S, Kim SH, Yeo H, Bok J, Kim J, Park M, Kim D, Lamiable O, Lee M, Kim MJ, Kim HY, Ronchese F, Kwon SW, Lee H, Kim TG, Chung Y
Cell Rep.
2024 Jul 23;
43(7).
doi: 10.1016/j.celrep.2024.114364
PMID: 38900635

Foxp3(+) Treg control allergic skin inflammation by restricting IFN-γ-driven neutrophilic infiltration and NETosis.

Tong X, Kim SH, Che L, Park J, Lee J, Kim TG
J Dermatol Sci.
2024 Jul;
115(1).
doi: 10.1016/j.jdermsci.2024.05.002
PMID: 38845244

High-dimensional profiling of regulatory T cells in psoriasis reveals an impaired skin-trafficking property.

Lee BH, Bang YJ, Lim SH, Kang SJ, Kim SH, Kim-Schulze S, Park CG, Kim HJ, Kim TG
EBioMedicine.
2024 Feb;
100().
doi: 10.1016/j.ebiom.2024.104985
PMID: 38306895

Skin microbe-dependent TSLP-ILC2 priming axis in early life is co-opted in allergic inflammation.

Cha J, Kim TG, Bhae E, Gwak HJ, Ju Y, Choe YH, Jang IH, Jung Y, Moon S, Kim T, Lee W, Park JS, Chung YW, Yang S, Kang YK, Hyun YM, Hwang GS, Lee WJ, Rho M, Ryu JH
Cell Host Microbe.
2024 Feb 14;
32(2).
doi: 10.1016/j.chom.2023.12.006
PMID: 38198924

Microenvironmental network of clonal CXCL13+CD4+ T cells and Tregs in pemphigus chronic blisters.

Han D, Lee AY, Kim T, Choi JY, Cho MY, Song A, Kim C, Shim JH, Kim HJ, Kim H, D'Angio HB, Preska R, Mayer AT, Kim M, Choi EJ, Kim TG, Shin EC, Park K, Kim DY, Kim SC, Kim JH
J Clin Invest.
2023 Dec 1;
133(23).
doi: 10.1172/JCI166357
PMID: 37815865

Pellino-1 promotes intrinsic activation of skin-resident IL-17A-producing T cells in psoriasis.

Kim SH, Oh J, Roh WS, Park J, Chung KB, Lee GH, Lee YS, Kim JH, Lee HK, Lee H, Park CO, Kim DY, Lee MG, Kim TG
J Allergy Clin Immunol.
2023 May;
151(5).
doi: 10.1016/j.jaci.2022.12.823
PMID: 36646143

Education

Yonsei University College of Medicine 
Ph.D. (2012-2017) 

Yonsei University College of Medicine 
M.S. (2009-2011) 

Yonsei University College of Medicine 
M.D. (2001-2007)

Experience

Assistant Professor 
Department of Dermatology, Severance Hospital, Yonsei University College of Medicine (2021-Current) 

Translational Research Assistant Professor 
Department of Microbiology and Immunology, Yonsei University College of Medicine (2019-2021) 

Clinical Fellow 
Department of Dermatology, Severance Hospital, Yonsei University College of Medicine (2017-2019) 

Visiting Fellow 
Anandasabapathy Lab, Department of Dermatology, Brigham & Women’s Hospital, Harvard Medical School, MA, Boston (2015-2016) 

Resident 
Department of Dermatology, Severance Hospital, Yonsei University College of Medicine (2008-2012) 

Intern 
Severance Hospital, Yonsei University College of Medicine (2007-2008)

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