Dr. Sarthak Gupta received his medical degree from Jawaharlal Nehru Medical College, Aligarh, India, and completed a residency in Internal Medicine at the State University of New York at Buffalo. He then moved to NIAMS to pursue a three-year adult rheumatology fellowship in 2011 and also served as the chief fellow for the training program. During his fellowship, he worked on defining the spectrum of anticytokine autoantibodies in autoimmune diseases. On completion of his fellowship, Dr. Gupta was promoted to Henry Metzger Scholar and subsequently joined the Systemic Autoimmunity Branch at NIAMS, where he worked on understanding the sex differences in neutrophil biology in systemic autoimmune diseases. He has also been an investigator on several ongoing clinical trials using novel therapies in systemic autoimmune diseases. In 2018 he accepted the position of assistant research physician at NIAMS where he continues to pursue his interest in translational research and developing innovative interventional studies in autoimmune diseases.

Dr. Gupta is an active clinician and a core faculty for the rheumatology training program at NIAMS. He has also received numerous awards and grants for his research, including the Rheumatology Research Foundation's Scientist Development Award, the 34th European Workshop for Rheumatology Research Travel Award and the 2017 ACR/EULAR Exchange Program award.

Scientific Publications

Pulmonary Manifestations of Primary Sjögren's Syndrome: Underlying Immunological Mechanisms, Clinical Presentation, and Management.

Gupta S, Ferrada MA, Hasni SA
Frontiers in immunology.
doi: 10.3389/fimmu.2019.01327
PMID: 31249572

Safety and Tolerability of Omalizumab: A Randomized Clinical Trial of Humanized Anti-IgE Monoclonal Antibody in Systemic Lupus Erythematosus.

Hasni S, Gupta S, Davis M, Poncio E, Temesgen-Oyelakin Y, Joyal E, Fike A, Manna Z, Auh S, Shi Y, Chan D, Carlucci P, Biehl A, Dema B, Charles N, Balow JE, Waldman M, Siegel RM, Kaplan MJ, Rivera J
Arthritis & rheumatology (Hoboken, N.J.).
2019 Jul;
doi: 10.1002/art.40828
PMID: 30597768

A High-Throughput Real-Time Imaging Technique To Quantify NETosis and Distinguish Mechanisms of Cell Death in Human Neutrophils.

Gupta S, Chan DW, Zaal KJ, Kaplan MJ
Journal of immunology (Baltimore, Md. : 1950).
2018 Jan 15;
doi: 10.4049/jimmunol.1700905
PMID: 29196457

Multicenter Systems Analysis of Human Blood Reveals Immature Neutrophils in Males and During Pregnancy.

Blazkova J, Gupta S, Liu Y, Gaudilliere B, Ganio EA, Bolen CR, Saar-Dover R, Fragiadakis GK, Angst MS, Hasni S, Aghaeepour N, Stevenson D, Baldwin N, Anguiano E, Chaussabel D, Altman MC, Kaplan MJ, Davis MM, Furman D
Journal of immunology (Baltimore, Md. : 1950).
2017 Mar 15;
doi: 10.4049/jimmunol.1601855
PMID: 28179497

The role of neutrophils and NETosis in autoimmune and renal diseases.

Gupta S, Kaplan MJ
Nature reviews. Nephrology.
2016 Jul;
doi: 10.1038/nrneph.2016.71
PMID: 27241241

Distinct Functions of Autoantibodies Against Interferon in Systemic Lupus Erythematosus: A Comprehensive Analysis of Anticytokine Autoantibodies in Common Rheumatic Diseases.

Gupta S, Tatouli IP, Rosen LB, Hasni S, Alevizos I, Manna ZG, Rivera J, Jiang C, Siegel RM, Holland SM, Moutsopoulos HM, Browne SK
Arthritis & rheumatology (Hoboken, N.J.).
2016 Jul;
doi: 10.1002/art.39607
PMID: 26815287


Jawaharlal Nehru Medical College, Aligarh, India


Henry Metzger Scholar in Translational Medicine
National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, MD

Clinical Fellow, Adult Rheumatology
National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, MD

Resident, Internal Medicine
State University of New York at Buffalo, Buffalo, NY

Last Updated: June 2020