Dr. Sarthak Gupta is a board-certified adult rheumatologist. He received his medical degree from Jawaharlal Nehru Medical College, Aligarh, India, and completed a residency in Internal Medicine at the State University of New York at Buffalo. He then moved to NIAMS to pursue a three-year adult rheumatology fellowship in 2011 and also served as the chief fellow for the training program. During his fellowship, he worked on defining the spectrum of anticytokine autoantibodies in autoimmune diseases. On completion of his fellowship, Dr. Gupta was promoted to Henry Metzger Scholar and subsequently joined the Systemic Autoimmunity Branch at NIAMS, where he worked on understanding the sex differences in neutrophil biology in systemic autoimmune diseases. He has also been an investigator on several ongoing clinical trials using novel therapies in systemic autoimmune diseases. In 2018 he accepted the position of assistant research physician at NIAMS where he continues to pursue his interest in translational research and developing innovative interventional studies in autoimmune diseases.

Dr. Gupta is an active clinician and a core faculty for the rheumatology training program at NIAMS. He has also received numerous awards and grants for his research, including the Rheumatology Research Foundation's Scientist Development Award, the 34th European Workshop for Rheumatology Research Travel Award and the 2017 ACR/EULAR Exchange Program award.

Scientific Publications

Quantification of Neutrophils Undergoing NET Formation and Distinguishing Mechanisms of Neutrophil Cell Death by Use of a High-Throughput Method.

Nakabo S, Kaplan MJ, Gupta S
Methods Mol Biol.
doi: 10.1007/978-1-0716-2553-8_11
PMID: 36087264

Joint-Predominant Rheumatic Complications of Immune Checkpoint Inhibitor Therapy in Patients with Thymic Epithelial Tumors.

Mullenix C, Ballman M, Chen H, Swift S, McAdams MJ, Tsai YT, Donahue RN, Poretta T, Gupta S, Loehrer PJ, Schlom J, Gulley JL, Rajan A
2022 Apr 5;
doi: 10.1093/oncolo/oyac026
PMID: 35380721

Lupus-like autoimmunity and increased interferon response in patients with STAT3-deficient hyper-IgE syndrome.

Goel RR, Nakabo S, Dizon BLP, Urban A, Waldman M, Howard L, Darnell D, Buhaya M, Carmona-Rivera C, Hasni S, Kaplan MJ, Freeman AF, Gupta S
J Allergy Clin Immunol.
2021 Feb;
doi: 10.1016/j.jaci.2020.07.024
PMID: 32768442

Sex differences in neutrophil biology modulate response to type I interferons and immunometabolism.

Gupta S, Nakabo S, Blanco LP, O'Neil LJ, Wigerblad G, Goel RR, Mistry P, Jiang K, Carmona-Rivera C, Chan DW, Wang X, Pedersen HL, Gadkari M, Howe KN, Naz F, Dell'Orso S, Hasni SA, Dempsey C, Buscetta A, Frischmeyer-Guerrerio PA, Kruszka P, Muenke M, Franco LM, Sun HW, Kaplan MJ
Proc Natl Acad Sci U S A.
2020 Jul 14;
doi: 10.1073/pnas.2003603117
PMID: 32601182

Bite of the wolf: innate immune responses propagate autoimmunity in lupus.

Gupta S, Kaplan MJ
J Clin Invest.
2021 Feb 1;
pii: 144918. doi: 10.1172/JCI144918
PMID: 33529160

A High-Throughput Real-Time Imaging Technique To Quantify NETosis and Distinguish Mechanisms of Cell Death in Human Neutrophils.

Gupta S, Chan DW, Zaal KJ, Kaplan MJ
J Immunol.
2018 Jan 15;
doi: 10.4049/jimmunol.1700905
PMID: 29196457

Correspondence on 'Clinical course of coronavirus disease 2019 (COVID-19) in a series of 17 patients with systemic lupus erythematosus under long-term treatment with hydroxychloroquine'.

Gupta S, Nakabo S, Chu J, Hasni S, Kaplan MJ
Ann Rheum Dis.
2023 Oct;
doi: 10.1136/annrheumdis-2020-219648
PMID: 33452005

Distinct Functions of Autoantibodies Against Interferon in Systemic Lupus Erythematosus: A Comprehensive Analysis of Anticytokine Autoantibodies in Common Rheumatic Diseases.

Gupta S, Tatouli IP, Rosen LB, Hasni S, Alevizos I, Manna ZG, Rivera J, Jiang C, Siegel RM, Holland SM, Moutsopoulos HM, Browne SK
Arthritis Rheumatol.
2016 Jul;
doi: 10.1002/art.39607
PMID: 26815287

Phase 1 double-blind randomized safety trial of the Janus kinase inhibitor tofacitinib in systemic lupus erythematosus.

Hasni SA, Gupta S, Davis M, Poncio E, Temesgen-Oyelakin Y, Carlucci PM, Wang X, Naqi M, Playford MP, Goel RR, Li X, Biehl AJ, Ochoa-Navas I, Manna Z, Shi Y, Thomas D, Chen J, Biancotto A, Apps R, Cheung F, Kotliarov Y, Babyak AL, Zhou H, Shi R, Stagliano K, Tsai WL, Vian L, Gazaniga N, Giudice V, Lu S, Brooks SR, MacKay M, Gregersen P, Mehta NN, Remaley AT, Diamond B, O'Shea JJ, Gadina M, Kaplan MJ
Nat Commun.
2021 Jun 7;
doi: 10.1038/s41467-021-23361-z
PMID: 34099646

Safety and Tolerability of Omalizumab: A Randomized Clinical Trial of Humanized Anti-IgE Monoclonal Antibody in Systemic Lupus Erythematosus.

Hasni S, Gupta S, Davis M, Poncio E, Temesgen-Oyelakin Y, Joyal E, Fike A, Manna Z, Auh S, Shi Y, Chan D, Carlucci P, Biehl A, Dema B, Charles N, Balow JE, Waldman M, Siegel RM, Kaplan MJ, Rivera J
Arthritis Rheumatol.
2019 Jul;
doi: 10.1002/art.40828
PMID: 30597768

Pulmonary Manifestations of Primary Sjögren's Syndrome: Underlying Immunological Mechanisms, Clinical Presentation, and Management.

Gupta S, Ferrada MA, Hasni SA
Front Immunol.
doi: 10.3389/fimmu.2019.01327
PMID: 31249572

Use of Magnetic Resonance Imaging to Identify Immune Checkpoint Inhibitor-Induced Inflammatory Arthritis.

Subedi A, Williams SG, Yao L, Maharjan S, Strauss J, Sharon E, Thomas A, Apolo AB, Gourh P, Hasni SA, Gulley JL, Kaplan MJ, Katz JD, Gupta S
JAMA Netw Open.
2020 Feb 5;
doi: 10.1001/jamanetworkopen.2020.0032
PMID: 32101306

Erosive Deforming Inflammatory Arthritis in a Patient With Cervical Adenocarcinoma.

Subedi A, Strauss J, Gupta S
JAMA Oncol.
2019 Nov 1;
doi: 10.1001/jamaoncol.2019.3140
PMID: 31556909

Somatic Mutations in UBA1 and Severe Adult-Onset Autoinflammatory Disease.

Beck DB, Ferrada MA, Sikora KA, Ombrello AK, Collins JC, Pei W, Balanda N, Ross DL, Ospina Cardona D, Wu Z, Patel B, Manthiram K, Groarke EM, Gutierrez-Rodrigues F, Hoffmann P, Rosenzweig S, Nakabo S, Dillon LW, Hourigan CS, Tsai WL, Gupta S, Carmona-Rivera C, Asmar AJ, Xu L, Oda H, Goodspeed W, Barron KS, Nehrebecky M, Jones A, Laird RS, Deuitch N, Rowczenio D, Rominger E, Wells KV, Lee CR, Wang W, Trick M, Mullikin J, Wigerblad G, Brooks S, Dell'Orso S, Deng Z, Chae JJ, Dulau-Florea A, Malicdan MCV, Novacic D, Colbert RA, Kaplan MJ, Gadina M, Savic S, Lachmann HJ, Abu-Asab M, Solomon BD, Retterer K, Gahl WA, Burgess SM, Aksentijevich I, Young NS, Calvo KR, Werner A, Kastner DL, Grayson PC
N Engl J Med.
2020 Dec 31;
doi: 10.1056/NEJMoa2026834
PMID: 33108101


Jawaharlal Nehru Medical College, Aligarh, India


Henry Metzger Scholar in Translational Medicine
National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, MD

Clinical Fellow, Adult Rheumatology
National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, MD

Resident, Internal Medicine
State University of New York at Buffalo, Buffalo, NY

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