Contact Information
Summary
Christoforos Meliadis, M.D., is a physician-scientist in the Laboratory of Skeletal Mechanobiology (Alliston Lab) at NIAMS. His work examines how osteocytes regulate cochlear bone quality and how this regulation shapes hearing during aging and in response to exercise. He uses multimodal approaches—including synchrotron imaging, spatial proteomics, and nanoscale biomechanical mapping—to define how skeletal biology contributes to auditory function.
Before joining NIAMS, Dr. Meliadis conducted postdoctoral research at the University of California, San Francisco, where he developed new approaches to studying cochlear bone biology, aging, and hearing in collaboration with the Advanced Light Source at Lawrence Berkeley National Laboratory. He earned his M.D. from the Medical School of the National and Kapodistrian University of Athens. His long-term goal is to become a surgeon-scientist and advance mechanistic and translational strategies to prevent and treat hearing loss.
Research Statement
Dr. Meliadis investigates how osteocytes regulate cochlear bone quality and how this regulation shapes hearing during aging and in response to exercise. Cochlear bone is among the most highly mineralized tissues in the body, yet how this specialized tissue is biologically regulated to support auditory function remains incompletely understood.
To address these questions, Dr. Meliadis applies a multimodal research approach integrating synchrotron imaging, spatial proteomics, biomechanical mapping, and auditory phenotyping. By integrating skeletal mechanobiology into hearing research, he aims to define how cochlear bone quality influences auditory function and to translate these insights into new strategies to prevent and treat hearing loss.
Scientific Publications
Education
National and Kapodistrian
University of Athens, Medical School MD (2014-2021)
Experience
Postdoctoral Scholar
University of California, San Francisco (UCSF) (2023-2026)