Summary

Brian Glancy graduated with a B.A. in Sport Science from the University of the Pacific prior to receiving a Master’s degree in Kinesiology and a Ph.D. in Exercise Science from Arizona State University working with Wayne Willis. He was a postdoctoral fellow with Robert Balaban at the National Heart, Lung, and Blood Institute from 2009 to 2016. Dr. Glancy became an Earl Stadtman Investigator at the NIH with a dual appointment between NHLBI and NIAMS in 2016. He is a member of the American College of Sports Medicine and the American Physiological Society.

Research Statement

Recently, Dr. Glancy demonstrated that skeletal muscle mitochondria form a highly connected network resembling that of an electrical power grid, and, indeed, were capable of electrical conduction of the mitochondrial membrane potential throughout the cell. The discovery of this rapid energy distribution mechanism overturned longstanding ideas regarding diffusion as the primary energy distribution pathway in skeletal muscle. Current work in this area is focused on providing a better understanding of the regulation and development of these mitochondrial networks as well as their role in overall muscle function.

Despite much interest, control of mitochondrial function in vivo remains largely unclear as direct measures of mitochondrial enzymes in live animals have been limited. As a result, another major focus of the Glancy lab is to develop and utilize novel, direct measurements of in vivo mitochondrial function in skeletal muscle under different workloads. The goal of these studies is to unravel the signaling cascade involved in the upregulation of mitochondrial energy conversion during muscle contraction.

Scientific Publications

The unified myofibrillar matrix for force generation in muscle.

Willingham TB, Kim Y, Lindberg E, Bleck CKE, Glancy B
Nature communications.
2020 Jul 24;
11(1).
doi: 10.1038/s41467-020-17579-6
PMID: 32709902

Subcellular connectomic analyses of energy networks in striated muscle.

Bleck CKE, Kim Y, Willingham TB, Glancy B
Nature communications.
2018 Nov 30;
9(1).
doi: 10.1038/s41467-018-07676-y
PMID: 30504768

Visualizing Mitochondrial Form and Function within the Cell.

Glancy B
Trends in molecular medicine.
2020 Jan;
26(1).
doi: 10.1016/j.molmed.2019.09.009
PMID: 31706841

MitoRACE: evaluating mitochondrial function in vivo and in single cells with subcellular resolution using multiphoton NADH autofluorescence.

Willingham TB, Zhang Y, Andreoni A, Knutson JR, Lee DY, Glancy B
The Journal of physiology.
2019 Nov;
597(22).
doi: 10.1113/JP278611
PMID: 31490555

Protein composition of the muscle mitochondrial reticulum during postnatal development.

Kim Y, Yang DS, Katti P, Glancy B
The Journal of physiology.
2019 May;
597(10).
doi: 10.1113/JP277579
PMID: 30919448

Endothelial cell nanotube insertions into cardiac and skeletal myocytes during coordinated tissue development.

Kim Y, Lindberg E, Bleck CKE, Glancy B
Cardiovascular research.
2020 Feb 1;
116(2).
doi: 10.1093/cvr/cvz285
PMID: 31688919

Education

Ph.D. Arizona State University, Exercise Science: 2006 – 2009

M.S.  Arizona State University, Kinesiology: 2004 – 2005

B.A. University of the Pacific, Sport Science: 2000 – 2004

Experience

Earl Stadtman Investigator, August 2016 – Current
NHLBI and NIAMS

Postdoctoral Fellow, September 2009 – August 2016
NHLBI

Graduate Research/Teaching Associate, Fall 2004 – Summer 2009
Arizona State University Department of Kinesiology

Last Updated: August 2020